RNF145 (Kr.5q33) , E3- Ubikitiiniligaasi

https://www.ncbi.nlm.nih.gov/gene/153830

Expression

Ubiquitous expression in lung (RPKM 33.4), gall bladder (RPKM 23.7) and 24 other tissues See more

Orthologs

mouse all

Related articles in PubMed

1. A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. Soranzo N, et al. Nat Genet, 2009 Nov. PMID 19820697, Free PMC Article
2. New gene functions in megakaryopoiesis and platelet formation. Gieger C, et al. Nature, 2011 Nov 30. PMID 22139419, Free PMC Article
3. Gene essentiality and synthetic lethality in haploid human cells. Blomen VA, et al. Science, 2015 Nov 27. PMID 26472760
4. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. Otsuki T, et al. DNA Res, 2005. PMID 16303743
5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

See all (6) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

Conserved Domains (3) summary

pfam12678
Location:564 → 605

zf-rbx1; RING-H2 zinc finger

pfam13639
Location:565 → 605

zf-RING_2; Ring finger domain

pfam13705
Location:38 → 536

TRC8_N; TRC8 N-terminal domain

 TITLE     A genome-wide meta-analysis identifies 22 loci associated with
            eight hematological parameters in the HaemGen consortium
  JOURNAL   Nat. Genet. 41 (11), 1182-1190 (2009)
   PUBMED   19820697
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK308394.1, BC042684.1 and AL831829.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK308394.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2158569 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..693
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q33.3"
     Protein         1..693
                     /product="RING finger protein 145 isoform 1"
                     /EC_number="2.3.2.27"
                     /calculated_mol_wt=79068
     Region          38..536
                     /region_name="TRC8_N"
                     /note="TRC8 N-terminal domain; pfam13705"
                     /db_xref="CDD:290425"
     Region          <564 ..605="" cdd="" cddsrv.cgi="" db_xref="CDD:<a href=" https:="" note="RING-H2 zinc finger; pfam12678" region_name="zf-rbx1" tructure="" uid="289448" www.ncbi.nlm.nih.gov="">289448

" Region 565..605 /region_name="zf-RING_2" /note="Ring finger domain; pfam13639" /db_xref="CDD:290367" Site order(567,570,582,584,587,590,601,604) /site_type="other" /note="cross-brace motif" /db_xref="CDD:238093" CDS 1..693 /gene="RNF145" /coded_by="NM_001199380.1:151..2232" /note="isoform 1 is encoded by transcript variant 1" /db_xref="CCDS:CCDS56393.1" /db_xref="GeneID:153830" /db_xref="HGNC:HGNC:20853" ORIGIN 1 mhrdrispsn sptwslqvfs kkkkkkkknn maakekleav lnvalrvpsi mlldvlyrwd 61 vssffqqiqr sslsnnplfq ykylalnmhy vgyilsvvll tlprqhlvql ylyfltalll 121 yaghqisrdy vrselefaye gpmyleplsm nrfttaligq lvvctlcscv mktkqiwlfs 181 ahmlpllarl clvpletivi inkfamiftg levlyflgsn llvpynlaks ayrelvqvve 241 vygllalgms lwnqlvvpvl fmvfwlvlfa lqiysyfstr dqpasrerll flfltsiaec 301 cstpysllgl vftvsfvalg vltlckfylq gyrafmndpa mnrgmtegvt llilavqtgl 361 ielqvvhraf llsiilfivv asilqsmlei adpivlalga srdkslwkhf ravslclfll 421 vfpaymaymi cqffhmdfwl liiisssilt slqvlgtlfi yvlfmveefr kepvenmddv 481 iyyvngtyrl leflvalcvv aygvsetifg ewtvmgsmii fihsyynvwl raqlgwksfl 541 lrrdavnkik slpiatkeql ekhndicaic yqdmksavit pcshffhagc lkkwlyvqet 601 cplchchlkn ssqlpglgte pvlqphagae qnvmfqegte ppgqehtpgt riqegsrdnn 661 eyiarrpdnq egafdpkeyp hsakdeahpv esa //