KLHL27, IPP (1p34.1) Intrakisternaalin A partikkelin(IAP) edistämä polypeptidi , aktiinia sitova proteiini IPP

https://genecards.weizmann.ac.il/v3/cgi-bin/carddisp.pl?gene=IPP

External Ids:	HGNC: 61081	Entrez Gene: 36522	Ensembl: ENSG000001974297	OMIM: 1474855	UniProtKB: Q9Y5733

Export aliases for IPP gene to outside databases Also known as KLHL27

Summary The protein encoded by this gene is a member of the kelch family of proteins, which is characterized by a 50 amino acid repeat which interacts with actin. Transcript variants have been described but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

Expression Ubiquitous expression in thyroid (RPKM 2.7), testis (RPKM 2.4) and 25 other tissues See more

ORIGIN      
        1 manedcpkaa dspfssdkha qlilaqinkm rngqhfcdvq lqvgqesfka hrlvlaassp
       61 yfaalftggm kesskdvvpi lgieagifqi lldfiytgiv nigvnnvqel iiaadmlqlt
      121 evvhlccefl kgqidplnci gifqfseqia chdllefsen yihvhflevh sgeeflaltk
      181 dqlikilrse elsiedeyqv flaamqwilk dlgkrrkhvv evldpirfpl lppqrllkyi
      241 egvsdfnlrv alqtllkeyc evckspkenk fcsflqtskv rprkkarkyl yavggytrlq
      301 ggrwsdsral scverfdtfs qywttvsslh qarsglgvtv lggmvyaigg ekdsmifdct
      361 ecydpvtkqw ttvasmnhpr cglgvcvcyg aiyalggwvg aeigntierf dpdenkwevv
      421 gnmavsryyf gccemqgliy viggisnegi elrsfevydp lskrwsplpp mgtrraylgv
      481 aalndciysv ggwnetqdal htvekysfee ekwvevasmk vpragmcvva vngllyvsgg
      541 rssshdflap dthryevfrl kwenmcilfn dhktltkgif nl

Aliases
Intracisternal A Particle-Promoted Polypeptide1 2 3
Kelch-Like Family Member 271 2
Kelch-Like Protein 272 3
KLHL272 3
Actin-Binding Protein IPP2 PubMed:   Isolation and characterization of IPP, a novel human gene encoding an actin-binding, kelch-like protein. Kim IF, et al. Gene, 1999 Mar 4. PMID 10072760The kelch family of proteins is defined by a 50 amino-acid repeat that has been shown to associate with actin. Here we describe the cloning and initial characterization of IPP, a novel human gene that predicts a kelch family protein homologous to the mouse Ipp gene, a previously described kelch family member. A 3kb IPP cDNA clone was isolated from a human placenta library using a probe derived from Ipp. Restriction mapping and Southern blot analysis show that IPP comprises eight exons spanning more than 47kb of genomic DNA. Fluorescence in situ hybridization maps the gene to chromosome 1p32-1p34. Northern blot analysis reveals transcripts of 1.4, 2.2, 5. 0, and 7.3kb. The 1.4 and 2.2kb messages are found exclusively in testis, while the 5.0 and 7.3kb messages are expressed at varying levels in ovary, placenta, small intestine, spleen, testis, and thymus. The IPP cDNA clone contains a 1752bp open reading frame that predicts a 584 amino-acid, 66kDa protein. Sequence analysis indicates an N-terminal POZ protein-protein interaction domain and a C-terminal kelch repeat domain consisting of six tandemly arranged repeats. Cosedimentation assays performed with these domains expressed as glutathione S-transferase fusion proteins demonstrate an actin-bindg activity mediated specifically by the kelch repeat domain of IPP. The IPP gene is assigned to human chromosome 1p32-1p22. Chang-Yeh A, et al. Genomics, 1993 Jan. PMID 8432546 Identification of a novel murine IAP-promoted placenta-expressed gene. Chang-Yeh A, et al. Nucleic Acids Res, 1991 Jul 11. PMID 1906605, Free PMC Article Cell lineage-specific expression of the MIPP gene. Mold DE, et al. Biochem Biophys Res Commun, 1991 Jun 28. PMID 1905535Expression of the MIPP gene parallels that of IAP genes in normal mouse tissues with abundant transcripts present in the placenta and also in the myeloma MOPC-315. The MIPP-encoded protein is composed of four 48-amino acid repeat units and shares homology with a vaccinia virus gene product. MIPP-related sequences were also detected in higher eukaryotic genomes including human. See all (17) citations in PubMed