KLHL23 (2q31.1) , DITHP motif, RGYW motif, LLxxL motif

https://www.ncbi.nlm.nih.gov/gene/151230

Also known as

DITHP

Expression Ubiquitous expression in endometrium (RPKM 12.1), brain (RPKM 7.8) and 22 other tissues See more

Related articles in PubMed

1. Downregulation of two novel genes in Sl/Sld and W(LacZ)/Wv mouse jejunum. Wouters MM, et al. Biochem Biophys Res Commun, 2006 Jul 28. PMID 16765319
2. Update on the Kelch-like (KLHL) gene family. Dhanoa BS, et al. Hum Genomics, 2013 May 15. PMID 23676014, Free PMC Article
3. Mapping the interactome of HPV E6 and E7 oncoproteins with the ubiquitin-proteasome system. Poirson J, et al. FEBS J, 2017 Oct. PMID 28786561
4. A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. Taipale M, et al. Cell, 2014 Jul 17. PMID 25036637, Free PMC Article
5. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. Taipale M, et al. Cell, 2012 Aug 31. PMID 22939624, Free PMC Article

See all (18) citations in PubMed

kelch-like protein 23 [Homo sapiens]

NCBI Reference Sequence: NP_653312.2

Identical Proteins FASTA Graphics

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LOCUS       NP_653312                558 aa            linear   PRI 02-MAY-2019
DEFINITION  kelch-like protein 23 [Homo sapiens].
ACCESSION   NP_653312
VERSION     NP_653312.2
DBSOURCE    REFSEQ: accession NM_144711.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 558)
  AUTHORS   Taipale M, Tucker G, Peng J, Krykbaeva I, Lin ZY, Larsen B, Choi H,
            Berger B, Gingras AC and Lindquist S.
  TITLE     A quantitative chaperone interaction network reveals the
            architecture of cellular protein homeostasis pathways
  JOURNAL   Cell 158 (2), 434-448 (2014)
   PUBMED   25036637
REFERENCE   2  (residues 1 to 558)
  AUTHORS   Dhanoa BS, Cogliati T, Satish AG, Bruford EA and Friedman JS.
  TITLE     Update on the Kelch-like (KLHL) gene family
  JOURNAL   Hum. Genomics 7, 13 (2013)
   PUBMED   23676014
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 558)
  AUTHORS   Comuzzie AG, Cole SA, Laston SL, Voruganti VS, Haack K, Gibbs RA
            and Butte NF.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS ONE 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   4  (residues 1 to 558)
  AUTHORS   Wouters MM, Neefs JM, Kerchove d'Exaerde Ad, Vanderwinden JM and
            Smans KA.
  TITLE     Downregulation of two novel genes in Sl/Sld and W(LacZ)/Wv mouse
            jejunum
  JOURNAL   Biochem. Biophys. Res. Commun. 346 (2), 491-500 (2006)
   PUBMED   16765319
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC009967.8, BJ990781.1, BC010437.1 and BE326381.1.
            On Dec 20, 2003 this sequence version replaced NP_653312.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.50521.1,
                                           SRR1803612.227762.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000392647.7/ ENSP00000376419.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..558
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q31.1"
     Protein         1..558
                     /product="kelch-like protein 23"
                     /note="kelch-like 23"
                     /calculated_mol_wt=63792
     Region          45..545
                     /region_name="BTB"
                     /note="Broad-Complex, Tramtrack and Bric a brac; cl28614"
                     /db_xref="CDD:333434"
     Region          274..320
                     /region_name="Kelch 1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8NBE8.1)"
     Region          310..355
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          321..369
                     /region_name="Kelch 2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8NBE8.1)"
     Region          359..402
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          370..416
                     /region_name="Kelch 3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8NBE8.1)"
     Region          406..495
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          418..466
                     /region_name="Kelch 4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8NBE8.1)"
     Region          467..508
                     /region_name="Kelch 5"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8NBE8.1)"
     Region          498..545
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          510..557
                     /region_name="Kelch 6"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8NBE8.1)"
     CDS             1..558
                     /gene="KLHL23"
                     /gene_synonym="DITHP"
                     /coded_by="NM_144711.6:259..1935"
                     /db_xref="CCDS:CCDS2236.1"
                     /db_xref="GeneID:151230"
                     /db_xref="HGNC:HGNC:27506"
ORIGIN      
        1 malkgqedyi ylfkdsthpv dfldafrtfy ldglftditl qcpsgiifhc hravlaacsn
       61 yfkamftadm kekfknkikl sgihhdileg lvnyaytsqi eitkrnvqsl leaadllqfl
      121 svkkacerfl vrhldidnci gmhsfaefhv cpelekesrr ilcskfkevw qqeefleisl
      181 ekflfilsrk nlsvwkeeai iepvikwtah dvenriecly nllsyinidi dpvylktalg
      241 lqrscllten kirsliynal npmhkeisqr statmyiigg yywhplsevh iwdpltnvwi
      301 qgaeipdytr esygvtclgp niyvtggyrt dniealdtvw iynsesdewt eglpmlnary
      361 yhcavtlggc vyalggyrkg apaeeaefyd plkekwipia nmikgvgnat acvlhdviyv
      421 igghcgyrgs ctydkvqsyn sdinewslit ssphpeyglc svpfenklyl vggqttitec
      481 ydpeqnewre iapmmerrme cgavimngci yvtggysysk gtylqsieky dpdlnkweiv
      541 gnlpsamrsh gcvcvynv
//