Leta i den här bloggen


måndag 28 oktober 2019

KLHDC3 (6p21.1), PEAS, dJ20C7.3, meioosirekombinaatiogeeni

https://www.ncbi.nlm.nih.gov/gene/116138 
Also known as
PEAS; dJ20C7.3
Summary
The protein encoded by this gene contains six repeated kelch motifs that are structurally similar to recombination activating gene 2, a protein involved in the activation of the V(D)J recombination. In mouse, this gene is found to be expressed specifically in testis. Its expression in pachytene spermatocytes is localized to, cytoplasma and meiotic chromatin, suggesting that this gene may be involved in meiotic recombination. [provided by RefSeq, Jun 2012]
Expression
Broad expression in testis (RPKM 98.0), brain (RPKM 70.2) and 25 other tissues See more
Preferred Names
kelch domain-containing protein 3
Names
testis intracellular mediator protein
  1. NM_057161.4NP_476502.1  kelch domain-containing protein 3
    See identical proteins and their annotated locations for NP_476502.1
    ORIGIN      
            1 mlrwtvhleg gprrvnhaav avghrvysfg gycsgedyet lrqidvhifn avslrwtklp
           61 pvksairgqa pvvpymrygh stvliddtvl lwggrndteg acnvlyafdv nthkwftprv
          121 sgtvpgardg hsacvlgkim yifggyeqqa dcfsndihkl dtstmtwtli ctkgsparwr
          181 dfhsatmlgs hmyvfggrad rfgpfhsnne iycnrirvfd trteawldcp ptpvlpegrr
          241 shsafgynge lyifggynar lnrhfhdlwk fnpvsftwkk iepkgkgpcp rrrqcccivg
          301 dkivlfggts pspeeglgde fdlidhsdlh ildfspslkt lcklaviqyn ldqsclphdi
          361 rwelnamttn snisrpivss hg
    //
     
    Conserved Domains (3) summary
    sd00038
    Location:128173
    Kelch; KELCH repeat [structural motif]
    pfam13964
    Location:1461
    Kelch_6; Kelch motif
    cl26061
    Location:74318
    PLN02193; nitrile-specifier protein
https://www.ncbi.nlm.nih.gov/pubmed/20353815 ..
Cul5-type Ubiquitin Ligase KLHDC1 Contributes to the Elimination of Truncated SELENOS Produced by Failed UGA/Sec Decoding
YuhaFujiki1

Inga kommentarer:

Skicka en kommentar