KLHL9 (9p2.3) . Solusyklin säätelijäkompleksin adaptoriosa mitoosissa ja sytokineesissä

https://www.ncbi.nlm.nih.gov/gene/55958

Summary This gene encodes a protein that belongs to the kelch repeat-containing family, and contains an N-terminal BTB/POZ domain, a BACK domain and six C-terminal kelch repeats. The encoded protein is a component of a complex with cullin 3-based E3 ligase, which plays a role in mitosis. This protein complex is a cell cycle regulator, and functions in the organization and integrity of the spindle midzone in anaphase and the completion of cytokinesis. The complex is required for the removal of the chromosomal passenger protein aurora B from mitotic chromosomes. [provided by RefSeq, Jul 2016]

Orthologs mouse all

 

ORIGIN      
        1 mkvslgngem gvsahlqpck agttrfftsn thssvvlqgf dqlriegllc dvtlvpgdgd
       61 eifpvhramm asasdyfkam ftggmkeqdl mciklhgvnk vglkkiidfi ytaklslnmd
      121 nlqdtleaas flqilpvldf ckvflisgvs ldncvevgri antynlievd kyvnnfilkn
      181 fpallstgef lklpferlaf vlssnslkhc telelfkaac rwlrledprm dyaaklmkni
      241 rfplmtpqdl inyvqtvdfm rtdntcvnll leasnyqmmp ymqpvmqsdr tairsdsthl
      301 vtlggvlrqq lvvskelrmy deraqewrsl apmdapryqh giavignfly vvggqsnydt
      361 kgktavdtvf rfdprynkwm qvaslnekrt ffhlsalkgh lyavggrsaa gelatvecyn
      421 prmnewsyva kmsephygha gtvygglmyi sggithdtfq nelmcfdpdt dkwmqkapmt
      481 tvrglhcmct vgdklyvigg nhfrgtsdyd dvlsceyysp tldqwtpiaa mlrgqsdvgv
      541 avfenkiyvv ggyswnnrcm veivqkydpe kdewhkvfdl peslggirac tltvfppeen
      601 pgspsrespl sapsdhs
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1. Kelch-like homologue 9 mutation is associated with an early onset autosomal dominant distal myopathy. Cirak S, et al. Brain, 2010 Jul. PMID 20554658, Free PMC Article
2. Pan-genome isolation of low abundance transcripts using SAGE tag. Kim YC, et al. FEBS Lett, 2006 Dec 11. PMID 17113583, Free PMC Article
3. Ubiquitylation-dependent localization of PLK1 in mitosis. Beck J, et al. Nat Cell Biol, 2013 Apr. PMID 23455478
4. A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cells. Sumara I, et al. Dev Cell, 2007 Jun. PMID 17543862. Faithful cell-cycle progression is tightly controlled by the ubiquitin-proteasome system. Here we identify a human Cullin 3-based E3 ligase (Cul3) which is essential for mitotic division. In a complex with the substrate-specific adaptors KLHL9 and KLHL13, Cul3 is required for correct chromosome alignment in metaphase, proper midzone and midbody formation, and completion of cytokinesis. This Cul3-based E3 ligase removes components of the chromosomal passenger complex from mitotic chromosomes and allows their accumulation on the central spindle during anaphase. Aurora B directly binds to the substrate-recognition domain of KLHL9 and KLHL13 in vitro, and coimmunoprecipitates with the Cul3 complex during mitosis. Moreover, Aurora B is ubiquitylated in a Cul3-dependent manner in vivo, and by reconstituted Cul3/KLHL9/KLHL13 ligase in vitro. We thus propose that the Cul3/KLHL9/KLHL13 E3 ligase controls the dynamic behavior of Aurora B on mitotic chromosomes, and thereby coordinates faithful mitotic progression and completion of cytokinesis.
5. USP25 regulates Wnt signaling by controlling the stability of tankyrases. Xu D, et al. Genes Dev, 2017 May 15. PMID 28619731, Free PMC Article

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