KLHL26 (19p13.11)

https://www.ncbi.nlm.nih.gov/gene/55295
( Huomaa tämä kromosomaali kohta 19p13.11  ja siihen sijoittvat muut proteiini. Cytokineesi, midbody, MVB, ESCART-1  ym tekijöistä) .

Expression

Ubiquitous expression in brain (RPKM 4.1), kidney (RPKM 2.8) and 25 other tissues See more

kelch-like protein 26 isoform 1 [Homo sapiens]

1. Genome wide study of maternal and parent-of-origin effects on the etiology of orofacial clefts. Shi M, et al. Am J Med Genet A, 2012 Apr. PMID 22419666, Free PMC Article
2. Update on the Kelch-like (KLHL) gene family. Dhanoa BS, et al. Hum Genomics, 2013 May 15. PMID 23676014, Free PMC Article
3. Regulation of the CUL3 Ubiquitin Ligase by a Calcium-Dependent Co-adaptor. McGourty CA, et al. Cell, 2016 Oct 6. PMID 27716508
4. Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation. Scott DC, et al. Cell, 2016 Aug 25. PMID 27565346, Free PMC Article
5. Mapping the interactome of HPV E6 and E7 oncoproteins with the ubiquitin-proteasome system. Poirson J, et al. FEBS J, 2017 Oct. PMID 28786561

See all (19) citations in PubMed

NCBI Reference Sequence: NP_001332910.1

Identical Proteins FASTA Graphics

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LOCUS       NP_001332910             644 aa            linear   PRI 31-MAY-2019
DEFINITION  kelch-like protein 26 isoform 1 [Homo sapiens].
ACCESSION   NP_001332910
VERSION     NP_001332910.1
DBSOURCE    REFSEQ: accession NM_001345981.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 644)
  AUTHORS   Dhanoa BS, Cogliati T, Satish AG, Bruford EA and Friedman JS.
  TITLE     Update on the Kelch-like (KLHL) gene family
  JOURNAL   Hum. Genomics 7, 13 (2013)
   PUBMED   23676014
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 644)
  AUTHORS   Shi M, Murray JC, Marazita ML, Munger RG, Ruczinski I, Hetmanski
            JB, Wu T, Murray T, Redett RJ, Wilcox AJ, Lie RT, Jabs EW, Wu-Chou
            YH, Chen PK, Wang H, Ye X, Yeow V, Chong SS, Shi B, Christensen K,
            Scott AF, Patel P, Cheah F and Beaty TH.
  TITLE     Genome wide study of maternal and parent-of-origin effects on the
            etiology of orofacial clefts
  JOURNAL   Am. J. Med. Genet. A 158A (4), 784-794 (2012)
   PUBMED   22419666
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008998.5 and AC004476.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CK825077.1, BM272514.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2146236, SAMEA2155590
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..644
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     Protein         1..644
                     /product="kelch-like protein 26 isoform 1"
                     /note="kelch-like protein 26; kelch-like 26"
                     /calculated_mol_wt=71431
     CDS             1..644
                     /gene="KLHL26"
                     /coded_by="NM_001345981.2:28..1962"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:55295"
                     /db_xref="HGNC:HGNC:25623"
ORIGIN      
        1 maesggssgg aggggafgag pgperpnsta dkngalkctf sapshstsll qglatlraqg
       61 qlldvvltin reafpahkvv laacsdyfrl lfprpdhswl aktplshcqp hvvflpfram
      121 ftggmreasq dvielkgvsa rglrhiidfa ysaevtldld cvqdvlgaav flqmlpvvel
      181 ceeflkaams vetclnigqm attfslaslr esvdaftfrh flqiaeeedf lrlplerlvf
      241 flqsnrlqsc aeidlfraav rwlqhdparr prashvlchi rfplmqssel vdsvqtldim
      301 vedvlcrqyl leafnyqvlp frqhemqspr tavrsdvpsl vtfggtpytd sdrsvsskvy
      361 qlpepgarhf reltemevgc shtcvavldn fvyvaggqhl qyrsgegavd acyrydphln
      421 rwlrlqamqe sriqfqlnvl cgmvyatggr nragslasve rycprrnewg yacslkrrtw
      481 ghagaasggr lyisggygis vedkkalhcy dpvadqwefk apmseprvlh amvgaggriy
      541 alggrmdhvd rcfdvlavey yvpetdqwts vspmragqse agccllerki yivggynwrl
      601 nnvtgivqvy ntdtdewerd lhfpesfagi acapvllpra gtrr
//