J Exp Bot. 2017 Apr 1;68(9):2135-2148. doi: 10.1093/jxb/erx118.
Dehydration responsive element binding transcription factors and their applications for the engineering of stress tolerance.
Abstract
Dehydration responsive element binding (DREB) factors or CRT element binding factors (CBFs) are members of the AP2/ERF family, which comprises a large number of stress-responsive
regulatory genes. This review traverses almost two decades of research,
from the discovery of DREB/CBF factors to their optimization for
application in plant biotechnology. In this review, we describe (i) the
discovery, classification, structure, and evolution of DREB genes and
proteins; (ii) induction of DREB genes by abiotic stresses and
involvement of their products in stress responses; (iii) protein
structure and DNA binding selectivity of different groups of DREB
proteins; (iv) post-transcriptional and post-translational mechanisms of
DREB transcription factor (TF) regulation; and (v) physical and/or
functional interaction of DREB TFs with other proteins during plant
stress responses. We also discuss existing issues in applications of
DREB TFs for engineering of enhanced stress tolerance and improved
performance under stress of transgenic crop plants.
©
The Author 2017. Published by Oxford University Press on behalf of the
Society for Experimental Biology. All rights reserved. For permissions,
please email: journals.permissions@oup.com. KEYWORDS:
Abiotic stress tolerance; CBF; DREB; plant biotechnology; transcription factor; yield.
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