KBTBD4 (11p11.2), BKLHD4, FLJ10450, HSPC252. mutarotataasiperheen domeeni, virulenssifaktori?

 https://www.ncbi.nlm.nih.gov/gene/55709#gene-expression

 

Official Symbol

KBTBD4

kelch repeat and BTB domain containing 4

Also known as

BKLHD4; HSPC252

Expression

Ubiquitous expression in testis (RPKM 10.3), thyroid (RPKM 10.1) and 25 other tissues See more

Orthologs

mRNA and Protein(s)

1. NM_001318716.1 → NP_001305645.1  kelch repeat and BTB domain-containing protein 4 isoform c
   

    

   ORIGIN      
           1 mglpvprpgg gwtqvlgrsh resferagkc ggssseesky swqreklasm espeepgasm
          61 denyfvnytf kdrshsgrva qgimklclee elfadvtisv egrefqlhrl vlsaqscffr
         121 smftsnlkea hnrvivlqdv sesvfqllvd yiyhgtvklr aeelqeiyev sdmyqltslf
         181 eecsrflart vqvgnclqvm wladrhsdpe lytaakhcak thlaqlqnte eflhlphrll
         241 tdiisdgvpc sqnpteaiea winfnkeere afaeslrtsl keigenvhiy ligkessrth
         301 slavslhcae ddsisvsgqn slchqitaac khggdlyvvg gsiprrmwkc nnatvdwewc
         361 aplprdrlqh tlvsvpgkda iyslggktlq dtlsnaviyy rvgdnvwtet tqlevavsga
         421 aganlngiiy llggeendld fftkpsrliq cfdtetdkch vkpyvlpfag rmhaavhkdl
         481 vfivaegdsl vcynplldsf trlclpeaws sapslwkias cngsiyvfrd rykkgdanty
         541 kldpatsavt vtrgikvllt nlqfvla
   //

    

   Conserved Domains (6) summary

   smart00225
   Location:95 → 189

   BTB; Broad-Complex, Tramtrack and Bric a brac

   cd14733
   Location:191 → 249

   BACK_like; BTB-And-C-terminal-Kelch (BACK) domain and similar domains

   TIGR03548
   Location:403 → 560

   mutarot_permut; cyclically-permuted mutarotase family proteinMembers of this protein family show essentially full-length homology, cyclically permuted, to YjhT from Escherichia coli. YjhT was shown to act as a mutarotase for sialic acid, and by this ability to be able to act as a virulence factor. Members of the YjhT family (TIGR03547) and this cyclically-permuted family have multiple repeats of the beta-propeller-forming Kelch repeat.

   sd00038
   Location:328 → 363

   Kelch; KELCH repeat [structural motif]

   pfam00651
   Location:88 → 187

   BTB; BTB/POZ domain

   pfam07646
   Location:327 → 363

   Kelch_2; Kelch motif

 

 

 

 (Yleistä seulontaa)

 

1. Reversible oxidation of phosphatase and tensin homolog (PTEN) alters its interactions with signaling and regulatory proteins. Verrastro I, et al. Free Radic Biol Med, 2016 Jan. PMID 26561776
2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. Zhang QH, et al. Genome Res, 2000 Oct. PMID 11042152, Free PMC Article
3. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. Taipale M, et al. Cell, 2012 Aug 31. PMID 22939624, Free PMC Article
4. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. Bennett EJ, et al. Cell, 2010 Dec 10. PMID 21145461, Free PMC Article
5. A human protein-protein interaction network: a resource for annotating the proteome. Stelzl U, et al. Cell, 2005 Sep 23. PMID 16169070

See all (11) citations in PubMed