KLHL33(14q11.2) , sis. siaalihappoa mutarotatoivan domeenin, virulenssifaktorin

1. NM_001109997.3 → NP_001103467.2  kelch-like protein 33 isoform 2
   See identical proteins and their annotated locations for NP_001103467.2
   
   Status: VALIDATED

   Source sequence(s)

   AL355075, BC146954, BY797694

   Consensus CDS

   CCDS53882.1

   UniProtKB/Swiss-Prot

   A6NCF5

   UniProtKB/TrEMBL

   B2RUZ8

   Related

   ENSP00000341549.4, ENST00000344581.4

   Conserved Domains (5) summary

   smart00612
   Location:274 → 322

   Kelch; Kelch domain

   smart00875
   Location:75 → 175

   BACK; BTB And C-terminal Kelch

   TIGR03547
   Location:253 → 505

   muta_rot_YjhT; mutatrotase, YjhT family

   sd00038
   Location:312 → 355

   Kelch; KELCH repeat [structural motif]

   pfam01344
   Location:311 → 356

   Kelch_1; Kelch motif

    

    

    

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   kelch-like protein 33 isoform 2 [Homo sapiens]

   NCBI Reference Sequence: NP_001103467.2

   Identical Proteins FASTA Graphics

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   LOCUS       NP_001103467             533 aa            linear   PRI 22-MAR-2019
   DEFINITION  kelch-like protein 33 isoform 2 [Homo sapiens].
   ACCESSION   NP_001103467 XP_063481
   VERSION     NP_001103467.2
   DBSOURCE    REFSEQ: accession NM_001109997.3
   KEYWORDS    RefSeq.
   SOURCE      Homo sapiens (human)
     ORGANISM  Homo sapiens
               Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
               Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
               Catarrhini; Hominidae; Homo.
   REFERENCE   1  (residues 1 to 533)
     AUTHORS   Dhanoa BS, Cogliati T, Satish AG, Bruford EA and Friedman JS.
     TITLE     Update on the Kelch-like (KLHL) gene family
     JOURNAL   Hum. Genomics 7, 13 (2013)
      PUBMED   23676014
     REMARK    Publication Status: Online-Only
   REFERENCE   2  (residues 1 to 533)
     AUTHORS   Choy KW, Wang CC, Ogura A, Lau TK, Rogers MS, Ikeo K, Gojobori T,
               Lam DS and Pang CP.
     TITLE     Genomic annotation of 15,809 ESTs identified from pooled early
               gestation human eyes
     JOURNAL   Physiol. Genomics 25 (1), 9-15 (2006)
      PUBMED   16368877
   COMMENT     VALIDATED REFSEQ: This record has undergone validation or
               preliminary review. The reference sequence was derived from
               AL355075.6, BY797694.2 and BC146954.1.
               On Oct 31, 2009 this sequence version replaced NP_001103467.1.
               
               Sequence Note: This RefSeq record was created from transcript and
               genomic sequence data to make the sequence consistent with the
               reference genome assembly. The genomic coordinates used for the
               transcript record were based on transcript alignments.
               
               ##Evidence-Data-START##
               CDS exon combination :: SRR1660807.163528.1, SRR1660803.77381.1
                                       [ECO:0000331]
               RNAseq introns       :: single sample supports all introns
                                       SAMEA2142680 [ECO:0000348]
               ##Evidence-Data-END##
               
               ##RefSeq-Attributes-START##
               inferred exon combination :: based on alignments, homology
               ##RefSeq-Attributes-END##
   FEATURES             Location/Qualifiers
        source          1..533
                        /organism="Homo sapiens"
                        /db_xref="taxon:9606"
                        /chromosome="14"
                        /map="14q11.2"
        Protein         1..533
                        /product="kelch-like protein 33 isoform 2"
                        /note="kelch-like protein 33"
                        /calculated_mol_wt=57679
        Region          75..175
                        /region_name="BACK"
                        /note="BTB And C-terminal Kelch; smart00875"
                        /db_xref="CDD:197943"
        Site            order(83..85,88)
                        /site_type="other"
                        /note="Cullin binding site [polypeptide binding]"
                        /db_xref="CDD:269808"
        Site            order(98..99,106..107,111,116..117,119..120,122..124,
                        126..127)
                        /site_type="other"
                        /note="putative dimer interface [polypeptide binding]"
                        /db_xref="CDD:269808"
        Region          210..258
                        /region_name="Kelch 1"
                        /experiment="experimental evidence, no additional details
                        recorded"
                        /note="propagated from UniProtKB/Swiss-Prot (A6NCF5.2)"
        Region          253..505
                        /region_name="muta_rot_YjhT"
                        /note="mutatrotase, YjhT family; TIGR03547"
                        /db_xref="CDD:274641"
   
   mutatrotase, YjhT family
   Members of this protein family contain multiple copies of the beta-propeller-forming 
   Kelch repeat. All are full-length homologs to YjhT of Escherichia coli, 
   which has been identified as a mutarotase for sialic acid. This protein 
   improves bacterial ability to obtain host sialic acid, and thus serves 
   as a virulence factor. Some bacteria carry what appears to be a 
   cyclically permuted homolog of this protein.
        Region          261..310
                        /region_name="KELCH repeat"
                        /note="KELCH repeat [structural motif]"
                        /db_xref="CDD:276965"
        Region          273..322
                        /region_name="Kelch 2"
                        /experiment="experimental evidence, no additional details
                        recorded"
                        /note="propagated from UniProtKB/Swiss-Prot (A6NCF5.2)"
        Region          274..322
                        /region_name="Kelch"
                        /note="Kelch domain; smart00612"
                        /db_xref="CDD:128874"
        Region          311..356
                        /region_name="Kelch_1"
                        /note="Kelch motif; pfam01344"
                        /db_xref="CDD:279660"
        Region          312..355
                        /region_name="KELCH repeat"
                        /note="KELCH repeat [structural motif]"
                        /db_xref="CDD:276965"
        Region          323..369
                        /region_name="Kelch 3"
                        /experiment="experimental evidence, no additional details
                        recorded"
                        /note="propagated from UniProtKB/Swiss-Prot (A6NCF5.2)"
        Region          358..>393
                        /region_name="Kelch_1"
                        /note="Kelch motif; pfam01344"
                        /db_xref="CDD:279660"
        Region          359..405
                        /region_name="KELCH repeat"
                        /note="KELCH repeat [structural motif]"
                        /db_xref="CDD:276965"
        Region          371..418
                        /region_name="Kelch 4"
                        /experiment="experimental evidence, no additional details
                        recorded"
                        /note="propagated from UniProtKB/Swiss-Prot (A6NCF5.2)"
        Region          407..452
                        /region_name="Kelch_1"
                        /note="Kelch motif; pfam01344"
                        /db_xref="CDD:279660"
        Region          408..453
                        /region_name="KELCH repeat"
                        /note="KELCH repeat [structural motif]"
                        /db_xref="CDD:276965"
        Region          419..465
                        /region_name="Kelch 5"
                        /experiment="experimental evidence, no additional details
                        recorded"
                        /note="propagated from UniProtKB/Swiss-Prot (A6NCF5.2)"
        Region          455..501
                        /region_name="KELCH repeat"
                        /note="KELCH repeat [structural motif]"
                        /db_xref="CDD:276965"
        Region          467..514
                        /region_name="Kelch 6"
                        /experiment="experimental evidence, no additional details
                        recorded"
                        /note="propagated from UniProtKB/Swiss-Prot (A6NCF5.2)"
        CDS             1..533
                        /gene="KLHL33"
                        /coded_by="NM_001109997.3:412..2013"
                        /note="isoform 2 is encoded by transcript variant 2"
                        /db_xref="CCDS:CCDS53882.1"
                        /db_xref="GeneID:123103"
                        /db_xref="HGNC:HGNC:31952"
   ORIGIN      
           1 mllsgmresq gtevslrtis tqdlrllvsf aysgvvrarw pgllraaqaa lqyqssscld
          61 lcqkglargl sparclalfp maeapglerl wskarhyllt hlpavalcpa fpslpaacla
         121 elldsdelhv qeefeafvaa rcwlaanpet qeseakallr cvrfgrmstr elrrvraagl
         181 lppltpdllh qlmveadvpg qerrrepdra lvviggdglr pdmalrqpsr avwwarafrc
         241 gvglvrtvew gqlpalpapg rfrhgaasla gselyvcggq dfyshsntla stlrwepsqe
         301 dweemaplsq arslfslval dgklyalggr hndvaldsve tynpelnvwr papalpapcf
         361 ahaaailegq lyvsggcggt gqylaslmhy dpklekpgtf lspmgvprag hvmaalggrl
         421 yvagglgete dllsfeayel rtdswthlap lpsphvgaas avlqgellvl ggyshrtyal
         481 shlihaycpg lgrwlclgtl prpraempac iltlpavqhi alvptphqtk pag 

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