KBTBD8, (3p14.1), TA-KR, TAKRP , T-soluaktivaation kelch toistoja omaava proteiini

KBTBD8
https://www.ncbi.nlm.nih.gov/gene/84541

Also known as

TAKRP; TA-KRP

Expression Broad expression in lymph node (RPKM 10.1), testis (RPKM 4.7) and 14 other tissues See more

Preferred Names

kelch repeat and BTB domain-containing protein 8

Names

T-cell activation kelch repeat protein

kelch repeat and BTB (POZ) domain containing 8

1. NM_032505.3 → NP_115894.2  kelch repeat and BTB domain-containing protein 8
   See identical proteins and their annotated locations for NP_115894.2
2.  

   ORIGIN      
           1 maasadlsks sptpngipss dpasdamdpf hacsilkqlk tmydegqltd ivvevdhgkt
          61 fschrnvlaa ispyfrsmft sgltestqke vrivgveaes mdlvlnyayt srvilteanv
         121 qalftaasif qipsiqdqca kymishldpq nsigvfifad hyghqelgdr skeyirkkfl
         181 cvtkeqeflq ltkdqlisil dsddlnvdre ehvyesiirw feheqnerev hlpeifakci
         241 rfplmedtfi ekippqfaqa iakscvekgp sntngctqrl gmtasemiic fdaahkhsgk
         301 kqtvpcldiv tgrvfklckp pndlrevgil vspdndiyia ggyrpsssev sidhkaendf
         361 wmydhstnrw lskpsllrar igcklvyccg kmyaiggrvy egdgrnslks vecydsrenc
         421 wttvcampva mefhnaveyk ekiyvlqgef flfyepqkdy wgfltpmtvp riqglaavyk
         481 dsiyyiagtc gnhqrmftve aydielnkwt rkkdfpcdqs inpylklvlf qnklhlfvra
         541 tqvtveehvf rtsrknslyq yddiadqwmk vyetpdrlwd lgrhfecava klypqclqkv
         601 l
   //

   
   

   REFERENCE   1  (residues 1 to 601)
     AUTHORS   Werner A, Baur R, Teerikorpi N, Kaya DU and Rape M.
     TITLE     Multisite dependency of an E3 ligase controls
               monoubiquitylation-dependent cell fate decisions
     JOURNAL   Elife 7, e35407 (2018)
      PUBMED   29999490
     REMARK    GeneRIF: The authors found that CUL3 complexed with KBTBD8
               monoubiquitylates its essential targets only after these have been
               phosphorylated in multiple motifs by CK2, a kinase whose levels
               gradually increase during embryogenesis.
               Publication Status: Online-Only 

   Metazoan development depends on tightly regulated gene expression 
   programs that instruct progenitor cells to adopt specialized fates. 
   Recent work found that posttranslational modifications, such as 
   monoubiquitylation, can determine cell fate also independently of 
   effects on transcription, yet how monoubiquitylation is implemented 
   during development is poorly understood. Here, we have identified a 
   regulatory circuit that controls monoubiquitylation-dependent neural 
   crest specification by the E3 ligase CUL3 and its substrate adaptor 
   KBTBD8. We found that CUL3KBTBD8 monoubiquitylates its 
   essential targets only after these have been phosphorylated in multiple 
   motifs by CK2, a kinase whose levels gradually increase during 
   embryogenesis. Its dependency on multisite phosphorylation allows CUL3KBTBD8
    to convert the slow rise in embryonic CK2 into decisive recognition of 
   ubiquitylation substrates, which in turn is essential for neural crest 
   specification. We conclude that multisite dependency of an E3 ligase 
   provides a powerful mechanism for switch-like cell fate transitions 
   controlled by monoubiquitylation.

   Conserved Domains (6) summary

   smart00612
   Location:337 → 388

   Kelch; Kelch domain

   PHA03098
   Location:50 → 516

   PHA03098; kelch-like protein; Provisional

   sd00038
   Location:330 → 376

   Kelch; KELCH repeat [structural motif]

   pfam00651
   Location:39 → 144

   BTB; BTB/POZ domain

   pfam01344
   Location:379 → 428

   Kelch_1; Kelch motif

   pfam07707
   Location:153 → 250

   BACK; BTB And C-terminal Kelch

Related articles in PubMed

1. Multisite dependency of an E3 ligase controls monoubiquitylation-dependent cell fate decisions. Werner A, et al. Elife, 2018 Jul 12. PMID 29999490, Free PMC Article
2. Dimerization quality control ensures neuronal development and survival. Mena EL, et al. Science, 2018 Oct 12. PMID 30190310
3. Cell-fate determination by ubiquitin-dependent regulation of translation. Werner A, et al. Nature, 2015 Sep 24. PMID 26399832, Free PMC Article
4. Identification of 15 loci influencing height in a Korean population. Kim JJ, et al. J Hum Genet, 2010 Jan. PMID 19893584
5. Deep sequencing and proteomic analysis of the microRNA-induced silencing complex in human red blood cells. Azzouzi I, et al. Exp Hematol, 2015 May. PMID 25681748

See all (14) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene