KLHDC1, MST025, Suositeltu nimi: kelch domain-containing protein 1. (Koko: 406 a.a.)

https://www.ncbi.nlm.nih.gov/gene/122773
KLHCC1  ilmenee ovariossa ja kilpirauhasessa eniten.   Koko: 406 aminohappoa,

KLHDC1 kelch domain containing 1 [ Homo sapiens (human) ]

Official Symbol

KLHDC1

Official Full Name

kelch domain containing 1

Also known as

MST025

Expression

Ubiquitous expression in ovary (RPKM 2.8), thyroid (RPKM 2.6) and 25 other tissues See more

1. NM_172193.3 → NP_751943.1  kelch domain-containing protein 1
   See identical proteins and their annotated locations for NP_751943.1
   

   ORIGIN  ( 406  a.a.)      
           1 madsqlfcva eersghcavv dgnflyvwgg yvsiednevy lpndeiwtyd idsglwrmhl
          61 megelpasms gscgacingk lyifggyddk gysnrlyfvn lrtrdetyiw ekitdfegqp
         121 ptprdklscw vykdrliyfg gygcrrhsel qdcfdvhdas weeqifwgwh ndvhifdtkt
         181 qtwfqpeikg gvppqpraah tcavlgnkgy ifggrvlqtr mndlhylnld twtwsgriti
         241 ngespkhrsw htltpiaddk lflcgglsad niplsdgwih nvttncwkql thlpktrprl
         301 whtaclgken eimvfggskd dllaldtghc ndllifqtqp ysllrscldc igknsimles
         361 qisllppkll qqvlkkitfw aaanhreeqr vqkeetenky qwissn

   
    
   

   Conserved Domains (4) summary

   sd00038
   Location:13 → 65

   Kelch; KELCH repeat [structural motif]

   pfam13415
   Location:206 → 256

   Kelch_3; Galactose oxidase, central domain

   pfam13418
   Location:247 → 294

   Kelch_4; Galactose oxidase, central domain

   pfam13854
   Location:13 → 54

   Kelch_5; Kelch motif

1. Differential subcellular localization and activity of kelch repeat proteins KLHDC1 and KLHDC2. Chin KT, et al. Mol Cell Biochem, 2007 Feb. PMID 16964437 We have previously identified and characterized human KLHDC2/HCLP-1, a kelch repeat protein that interacts with and inhibits transcription factor LZIP. In this study, we identified and characterized a paralog of KLHDC2 called KLHDC1. KLHDC1 and KLHDC2 share about 50% identity at the level of amino acid sequence and both gene loci localize to human chromosome 14q21.3. This cluster of KLHDC1 and KLHDC2 genes is highly conserved in vertebrates ranging from pufferfish to human. Both genes are expressed highly in skeletal muscle, but weakly in various other tissues. While KLHDC2 was predominantly found in the nucleus, KLHDC1 is a cytoplasmic protein. Neither KLHDC1 nor KLHDC2 binds to actin. In addition, KLHDC1 was unable to inhibit LZIP/CREB3-mediated transcriptional activation. Thus, KLHDC1 and KLHDC2 have differential localization and activity in cultured mammalian cells.
2. Data show that KLHDC1 and KLHDC2 have differential localization and activity in cultured mammalian cells.
3.  Cul5-type Ubiquitin Ligase KLHDC1 Contributes to the Elimination of Truncated SELENOS Produced by Failed UGA/Sec Decoding
   Author links open overlay panelFumihikoOkumura¹⁶
   YuhaFujiki^{1 et al.} https://doi.org/10.1016/j.isci.2020.100970