Folia Haematol Int Mag Klin Morphol Blutforsch. 1986;113(3):329-42.
[The value of the free hydroxyproline and the N-acetyl-beta- glucosaminidase for the observation of the course of malignant tumors].
[Article in German]
Abstract
In 172 patients with various malign tumours the free hydroxyprolin
(HP) and N-acetyl-beta-glucosaminidase (beta-NAG) in the serum were
determined. The established values were analysed according to the kind
of tumour, spread of tumour, behaviour of growth and histological
classification and statistically evaluated. In mamma carcinoma
progressively metastasing into bones HP is significantly increased in
its mean value. 71.4 per cent of the patients have pathological values.
The parameter for bone-marrow diagnostics failed in 28.6 per cent.
Increases may only occur until 9 weeks before traditional diagnostics of
metastases. beta-NAG values lie within the normal range for clinically
not metastasing mamma carcinoma. The enzyme level will increase
significantly after each tumour progression into an organ. The
diagnostic sensitivity for the general diagnostics of metastases amounts
to 97.7 per cent. Increases without any evidence of metastases are
either due to other diseases with connective tissue changes or to occult
micrometastases. An exact control is required for these patients.
Likewise, HP and beta-NAG have a prognostic importance for malign
testicle tumours from nonseminomes character and malign lymphomas,
because with tumour progression they will turn into pathological ones.
Cytostatics have no direct impact on the serum level of HP and beta-NAG.
- PMID:
- 2428707
- [Indexed for MEDLINE]
Kommenttini: Hyp eli hydroxyproliini ei ole essentielli aminohappo, mutta posttranslationaalisti eräissä struktuureissa tapahtuu Pro-Hyp- muutos, ja se on rakenteissa essentielliä ( kollageeneissa). Tämä on vaativa prosessi ja säädelty entsymaattissti.
Se ei pystyne palautumaan proliiniksi, joka on struktuuriaminohappo.
Se näitten uusien artikkeleiden mukaan onkin patologisen tilan biomerkitsijä. uusimmassa Nobel palkinnon saaneessa aiheessa ja löydössä on yksi proteiini, jonka rakenne myös muuttuu hydroxyproliineiksi riippuen hapen saatavuudesta. Tässä vielä atjatelen että kyse täytyy olla posttranslationaalistasoisesta modifikaatiosta. Ei kai villi happi (ROS ) mitään hyvää ja järkevää säätelyä tuota. Täytyy katsoa tarkemmin.
Curr Protein Pept Sci. 2016;17(6):596-602.Hydroxyproline: A Potential Biochemical Marker and Its Role in the Pathogenesis of Different Diseases.
- 1
- Department of Pharmacology, Truba Institute of Pharmacy, Bhopal-462038, Madhya Pradesh, India. amitpharmacy21@gmail.com.
Abstract
Hydroxyproline is a non-essential amino acid found in collagen and few other extracellular animal proteins. It's two isomeric forms trans-4-hydroxy-L-proline and trans-3-hydroxy-L-proline play a crucial role in collagen synthesis and thermodynamic stability of the triple-helical conformation of collagen and associated tissues. Various abnormalities in hydroxyproline metabolism have been shown to play key roles in the pathophysiology and pathogenesis of different diseases. The elevated level of hydroxyproline is observed in several disorders, e.g., graft versus host disease, keloids, and vitiligo while its decreased level is a marker of poor wound-healing. This review explores the potential of using hydroxyproline as a biochemical marker to understand the pathogenesis, molecular pathophysiology and treatment of these diseases. The review concludes with an outlook on the scope and challenges in the clinical implementation of hydroxyproline as a biomarker.- PMID:
- 26916157
- [Indexed for MEDLINE]
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