KLHL10 (17q21.2) , SPGF11

https://www.ncbi.nlm.nih.gov/gene/317719

Also known as

SPGF11

Summary

The protein encoded by this gene belongs to the kelch repeat-containing family, and contains an N-terminal BTB/POZ domain a BACK domain and six C-terminal kelch repeats. Kelch domains are thought to form a four stranded beta-sheet blade structure that can fold into a beta-propeller domain when multiple kelch repeats are found together. Mutations in this gene have been associated with oligozoospermia in some infertile males. [provided by RefSeq, Jul 2016]

Expression

Restricted expression toward testis (RPKM 27.6) See more

Preferred Names

kelch-like protein 10

Names

testicular tissue protein Li 104

Related articles in PubMed

1. [Mutation of KLHL-10 in idiopathic infertile males with azoospermia, oligospermia or asthenospermia]. Qiu QM, et al. Zhonghua Nan Ke Xue, 2009 Nov. PMID 20218307
2. Haploinsufficiency of kelch-like protein homolog 10 causes infertility in male mice. Yan W, et al. Proc Natl Acad Sci U S A, 2004 May 18. PMID 15136734, Free PMC Article
3. Non-invasive genetic diagnosis of male infertility using spermatozoal RNA: KLHL10 mutations in oligozoospermic patients impair homodimerization. Yatsenko AN, et al. Hum Mol Genet, 2006 Dec 1. PMID 17047026
4. Update on the Kelch-like (KLHL) gene family. Dhanoa BS, et al. Hum Genomics, 2013 May 15. PMID 23676014, Free PMC Article
5. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. Taipale M, et al. Cell, 2012 Aug 31. PMID 22939624, Free PMC Article