https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507178/
Ihmisellekin on jäänyt tästä muistona geeniä, jolla on merkitystä.SNAIL- geenit, jotka ovat on transkriptionaalisia repressoreita 1. Ne säätää alas ektodermaalisia geenejä mesodermin sisässä alkiokehityksen tarpeen mukaisesti. Geeniä ilmenee solun tumajyväsessä ja proteiinia tumassa. Geemillä on alkiossa merkitystä mesodermin muodostumisessa normaalissa EMT/MET- prosessissa.
SNAIL2 geeni tunnetaan paremmin nimellä SLUG ja SNAIL3 nimellä SMUC. Tässä Sinkkisormiproteiiniryhmässä ZNF CH2H on 720 geeniä ja niistä transkriptiotekijöitä on 372. Muutama jäsen riitä ryhmästä maintiaan näiden SNAIL- proteiinien jälkeen sivun lopussa.
SNAIL1 (20q13.3) , SNAIL
https://www.ncbi.nlm.nih.gov/gene/6615
SNAI1 snail family transcriptional repressor 1 [ Homo sapiens (human) ]
- Also known as
- SNA; SNAH; SNAIL; SLUGH2; SNAIL1; dJ710H13.1
- Summary
- The Drosophila embryonic protein snail is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo. At least two variants of a similar processed pseudogene have been found on chromosome 2. [provided by RefSeq, Jul 2008]
- Expression Broad expression in gall bladder (RPKM 10.2), thyroid (RPKM 5.1) and 21 other tissues See more
- Orthologs mouse all
- Preferred Names
- zinc finger protein SNAI1
- Names
- protein sna
- protein snail homolog 1
- snail 1 homolog
- snail 1 zinc finger protein
- snail family zinc finger 1
- snail homolog 1
Related articles in PubMed
- Mechanisms underlying the increased chemosensitivity of bortezomib-resistant multiple myeloma by silencing nuclear transcription factor Snail1. Huang Z, et al. Oncol Rep, 2019 Jan. PMID 30365089
- High snail expression predicts a poor prognosis in breast invasive ductal carcinoma patients with HER2/EGFR-positive subtypes. Chang HY, et al. Surg Oncol, 2018 Jun. PMID 29937187
- Possible effect of SNAIL family transcriptional repressor 1 polymorphisms in non-syndromic cleft lip with or without cleft palate. Cura F, et al. Clin Oral Investig, 2018 Sep. PMID 29374328
- SNAIL1-mediated downregulation of FOXA proteins facilitates the inactivation of transcriptional enhancer elements at key epithelial genes in colorectal cancer cells. Jägle S, et al. PLoS Genet, 2017 Nov. PMID 29155818, Free PMC Article
- An analysis of suppressing migratory effect on human urinary bladder cancer cell line by silencing of snail-1. Salehi S, et al. Biomed Pharmacother, 2017 Dec. PMID 29032338
SNAIL2 (8q11.21) , SLUG
https://www.ncbi.nlm.nih.gov/gene/?term=SNAIL2
- Also known as
- SLUG; WS2D; SLUGH; SLUGH1; SNAIL2
- Summary
- This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects. [provided by RefSeq, Jul 2008]
- Expression Ubiquitous expression in endometrium (RPKM 22.8), ovary (RPKM 21.9) and 22 other tissues See more
- Orthologs mouse all
- Preferred Names
- zinc finger protein SNAI2
- Names
- neural crest transcription factor SLUG
- protein snail homolog 2
- slug (chicken homolog), zinc finger protein
- snail family zinc finger 2
- snail homolog 2
- [Inhibition of Histone Deacetylases Reverses Epithelial-Mesenchymal Transition in Triple-Negative Breast Cancer Cells through a Slug Mediated Mechanism]. Rahimian A, et al. Mol Biol (Mosk), 2018 May-Jun. PMID 29989579
- SNAI2 upregulation is associated with an aggressive phenotype in fulvestrant-resistant breast cancer cells and is an indicator of poor response to endocrine therapy in estrogen receptor-positive metastatic breast cancer. Alves CL, et al. Breast Cancer Res, 2018 Jun 19. PMID 29921289, Free PMC Article
- Evaluation of Slug expression is useful for predicting lymph node metastasis and survival in patients with gastric cancer. Lee HH, et al. BMC Cancer, 2017 Oct 3. PMID 28974196, Free PMC Article
- SLUG transcription factor: a pro-survival and prognostic factor in gastrointestinal stromal tumour. Pulkka OP, et al. Br J Cancer, 2017 Apr 25. PMID 28334729, Free PMC Article
- Increased risk of poor survival in ovarian cancer patients with high expression of SNAI2 and lymphovascular space invasion. Li J, et al. Oncotarget, 2017 Feb 7. PMID 28039463, Free PMC Article
https://www.ncbi.nlm.nih.gov/gene/333929
- Also known as
- SMUC; SNAIL3; ZNF293; Zfp293
- Summary
- SNAI3 is a member of the SNAIL gene family, named for the Drosophila snail gene, which plays roles in mesodermal formation during embryogenesis (Katoh and Katoh, 2003 [PubMed 12579345]).[supplied by OMIM, Apr 2009]
- Expression
- Broad expression in lymph node (RPKM 1.8), spleen (RPKM 1.7) and 25 other tissues See more
- Orthologs
- mouse all
- Preferred Names
- zinc finger protein SNAI3
- Names
- protein snail homolog 3
- snail family zinc finger 3
- snail homolog 3
- zinc finger protein 293
- Identification and characterization of human SNAIL3 (SNAI3) gene in silico. Katoh M, et al. Int J Mol Med, 2003 Mar. PMID 12579345
- Snail family members unequally trigger EMT and thereby differ in their ability to promote the neoplastic transformation of mammary epithelial cells. Gras B, et al. PLoS One, 2014. PMID 24638100, Free PMC Article
- Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex. Peinado H, et al. Mol Cell Biol, 2004 Jan. PMID 14673164, Free PMC Article
- E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. Khanna R, et al. FEBS J, 2018 Jun. PMID 29676528
- The BioPlex Network: A Systematic Exploration of the Human Interactome. Huttlin EL, et al. Cell, 2015 Jul 16. PMID 26186194, Free PMC Article
(PS: Muita tämä ZNF C2H2- tyypin proteiineja SNAIL perheenjäsenten (SNA1, SLUG ja SMUC) lisäksi on seuraavat jäsenet:
ZNF proteiinit:
KLF4, KLF5, EGR3, ZFP637, ZNF750, ZNF281, ZBP89, GLIS1, GLIS3)
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