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onsdag 22 maj 2019

CD38 on ADPR-syklaasi sekä syklisen ADPR-proteiinin hydrolaasi.

https://www.ncbi.nlm.nih.gov/gene/952

Also known as
ADPRC1; cADPR1; ADPRC 1
Summary
The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose (   cADPR) , an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Expression
Broad expression in lymph node (RPKM 11.2), brain (RPKM 10.3) and 17 other tissues See more

 

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