(5) ZMIZ5, (1q21.1) , E3-SUMO-proteiiniligaasi PIAS3, Znf proteiini MIZ-tyyppi, Akt. STAT3-inhiiittori

PIAS3 protein inhibitor of activated STAT 3 [ Homo sapiens (human) ]

(5) ZMIZ5, (PIAS3), (1) , https://www.ncbi.nlm.nih.gov/gene/10401

PIAS3, Also known as

ZMIZ5

Summary

This gene encodes a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It directly binds to several transcription factors and either blocks or enhances their activity. Alternatively spliced transcript variants of this gene have been identified, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

Expression Ubiquitous expression in endometrium (RPKM 17.3), skin (RPKM 16.3) and 25 other tissues See more Orthologs mouse all

Preferred Names

E3 SUMO-protein ligase PIAS3

Names

E3 SUMO-protein transferase PIAS3

protein inhibitor of activated STAT protein 3

zinc finger, MIZ-type containing 5

Peptide seq., History:

NP_006090.2  E3 SUMO-protein ligase PIAS3

Conserved Domains (3) summary

smart00513
Location:11 → 36

SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation

pfam02891
Location:323 → 371

zf-MIZ; MIZ/SP-RING zinc finger

pfam14324
Location:126 → 263

Related articles in PubMed

1. Protein Inhibitor of Activated STAT3 (PIAS3) Is Down-Regulated in Eutopic Endometrium of Women with Endometriosis. Yoo JY, et al. Biol Reprod, 2016 Jul. PMID 27226311, Free PMC Article
2. Prognostic value of protein inhibitor of activated STAT3 in breast cancer patients receiving hormone therapy. Yang SF, et al. BMC Cancer, 2016 Jan 14. PMID 26768588, Free PMC Article
3. Protein Inhibitor of Activated STAT3 Regulates Migration, Invasion, and Activation of Fibroblast-like Synoviocytes in Rheumatoid Arthritis. Lao M, et al. J Immunol, 2016 Jan 15. PMID 26667168
4. PIAS3 expression in squamous cell lung cancer is low and predicts overall survival. Abbas R, et al. Cancer Med, 2015 Mar. PMID 25573684, Free PMC Article
5. PIAS3 may represent a potential biomarker for diagnosis and therapeutic of human colorectal cancer. Li H, et al. Med Hypotheses, 2013 Dec. PMID 24120699

See all (110) citations in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

1. Concomitant gain of pSTAT3 Tyr705 and loss of PIAS3 appear critical for initiation and development of high-grade serous carcinoma.
2. Study reports that SMAD6 is overexpressed in nuclei of glioma cells, which correlates with poor patient survival and regulates STAT3 activity via negatively regulating PIAS3. Mechanically, SMAD6 interacts directly with PIAS3, and this interaction is mediated through the Mad homology 2 domain of SMAD6 and the Ring domain of PIAS3.
3. PAI-1 interacted with PIAS3 to regulate Stat3-dependent gene expression and miR-34a was transcriptionally suppressed by Stat3 to form a positive regulatory loop through Stat3 signaling in non-small cell lung cancer cells.
4. Levels of PIAS3 are significantly lower, in contrast with phosphorylation of STAT3, in women with endometriosis compared to women without endometriosis.
5. TRIM8 activates STAT3 by suppressing the expression of PIAS3, an inhibitor of STAT3, most likely through E3-mediated ubiquitination and proteasomal degradation.
6. Low PIAS3 expression is associated with breast cancer organoid invasiveness.
7. SHP2, SOCS3 and PIAS3 levels are reduced in medulloblastomas in vivo and in vitro, of which PIAS3 downregulation is more reversely correlated with STAT3 activation. In resveratrol-suppressed medulloblastoma cells with STAT3 downregulation and decreased incidence of STAT3 nuclear translocation, PIAS3 is upregulated, the SHP2 level remains unchanged and SOCS3 is downregulated.
8. The results revealed that although the expression levels of SOCS1, SOCS3 and, in particular, pSHP2, tend to decrease in the four types of astrocytomas, PIAS3 downregulation is more negatively correlated with STAT3 activation in the stepwise progress of astrocytomas and would indicate an unfavorable outcome.
9. 3-Formylchromone inhibits proliferation and induces apoptosis of multiple myeloma cells by abrogating STAT3 signaling through the induction of PIAS3.
10. PIAS3 may serve as a biomarker for predicting hormone therapy stratification, although it is limited to those breast cancer patients receiving hormone therapy.

Submit: New GeneRIF Correction See all GeneRIFs (48)