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fredag 24 maj 2019

(4) ZMIZ4 (18q21.1) , E3-SUMO-proteiiniligaasi PIAS2, (PIASx), Znf-proteiini MIZ-tyyppi, Akt.STAT2-inhibiittori,

PIAS2(PIASx) protein inhibitor of activated STAT 2 [ Homo sapiens (human) ]

(4) ZMIZ4 (18q21.1) , (PIAS2) https://www.ncbi.nlm.nih.gov/gene/9063
PIAS2 , Also known as
DIP; MIZ1; SIZ2; ARIP3; PIASX; ZMIZ4
Summary
This gene encodes a member of the protein inhibitor of activated STAT family, which function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. [provided by RefSeq, Aug 2017]
Expression Broad expression in testis (RPKM 8.9), thyroid (RPKM 2.1) and 23 other tissues See more -Orthologs mouse all
Preferred Names
E3 SUMO-protein ligase PIAS2
Names
DAB2-interacting protein, (DIP)
E3 SUMO-protein transferase PIAS2
androgen receptor-interacting protein 3, (ARIP)
msx-interacting zinc finger protein, (MIZ1)
protein inhibitor of activated STAT X, (PIASX)
zinc finger, MIZ-type containing 4, (ZMIZ4)
NP_001310976.1  E3 SUMO-protein ligase PIAS2 isoform 5 
Conserved Domains (3) summary
smart00513
Location:2 → 36
SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
pfam14324
Location:138 → 282
PINIT; PINIT domain
cd16790
Location:334 → 381
SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins

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