ASB3 (2p16.2) , ASB- perheenjäsenten E3 ubikitiiniligaasit

ASB3, ankyrin repeat and SOCS Box containing 3
 https://www.ncbi.nlm.nih.gov/gene/51130

Also known as

ASB-3

Summary

The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2011]

Expression

Ubiquitous expression in brain (RPKM 8.4), testis (RPKM 6.9) and 25 other tissues See more

Orthologs

mouse all

Conserved Domains (4) summary

cd00204
Location:33 → 159

ANK; ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other types of domains. The structural repeat unit contains two antiparallel helices and a beta-hairpin, repeats are stacked in a superhelical arrangement; this alignment contains 4 consecutive repeats.

cd03722
Location:384 → 434

SOCS_ASB3; SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha by direct targeting of tumor necrosis factor receptor II (TNF-R2) for ubiquitination and proteasome-mediated degradation. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.

pfam12796
Location:10 → 103

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:73 → 103

ANK; ANK repeat [structural motif]

(Lommentti:  Löydän uuden artikkelin  ASB- perheen proteiineista vuodelta 2018! Niitä on monta, josita useimmat  katsotaan E3 Ubikitiiniligaaseiksi.

Vivek Vishnu. Multifaceted roles of ASB proteins and its pathological significance (2018)

http://journal.hep.com.cn/fib/EN/10.1007/s11515-018-1506-2

BACKGROUND: Post-translational (PT) modification in cells regulates many intracellular events like signal transduction, transcription, cell cycle, protein quality control, apoptosis and cellular development. Ubiquitination is one of the PT modifications which functions as a marker for degradation of target proteins by the proteasome and as a regulatory mechanism for several signalling pathways. The ubiquitination mechanism requires multiple enzymes, including E1, E2, and E3 ligases. Among them, E3 ligases play a major role in recognizing target proteins and an essential feature of protein homeostatic mechanisms within the cell. Most of the ASB (ankyrin repeat SOCS box) proteins function as RING family of E3 ubiquitin ligases characterized by the presence of two conserved domains N-terminal ankyrin repeat and C-terminal SOCS box domain METHODS and RESULTS: Current studies have shown that some ASBs function as important regulators of several signalling pathways. This review gives an overview of ASB proteins on numerous cellular processes such as insulin signalling, spermatogenesis, myogenesis and in cellular development. Including various pathological situations, such as cancer, primary open-angle glaucoma, and inflammation, indicating that ASBs has important functions in both normal and pathological development CONCLUSIONS: This article provides a precise comprehensive focus on ASBs protein structure, its biological functions, and their pathological significance. Keywords ankyrin repeat      SOCS box      E3 ligase      cancer      spermatogenesis      cellular development      Corresponding Authors: Priti Talwar    Online First Date: 07 September 2018    Issue Date: 25 October 2018

ASB(2q37), Spermatogenesis.
E 3 ligase activity? Not defined (ND).

ASB2 (14q31-q32). Muscle differentiation. Substrates identified:  FLNA-B, JAK.
E 3 ligase: YES:

ASB3 (2p16-p14). Degradation of TNFR2.  Substrate identified:  TNFR2;
E-3 ligase: YES: 

ASB4,(7q21.3)   https://www.ncbi.nlm.nih.gov/gene/51666
Vascular differentiation, insuline signaling.  Substrates identified: GPS1, IRS4, ID2, HIFIalpha.
E3 Ligase: YES. 

ASB5, (4q34.2). Arteriogenesis.
ND.

ASB6, 9q34.13), Insulin signaling , Substrate identified: APS.
E3 ligase: YES.

ASB7,(15q26.31), Chromosomal stability,
E3 ligase: YES.

ASB8,(12q13.11), Spermatogenesis.
E3 ligase: YES.

ASB9,(Xp21.3),  Inhibition of cell growth;   Substrate identified: CKB.;
E3 ligase: YES..

ASB10, (7q36.1), Open angle glaucoma.
E3 ligase: YES.

ASB11,(Xp22.31), Neurogenesis and Notch signaling;   Substrates identified: Ribophorin 1, Delta A;
E3 ligase: YES. .

ASB12 (Xq11.2), Function/Substrate: Not studied/identified.
ND .

ASB13, 10p15.1), Function, Substrate .Not studie
ND.

ASB14, 3p21.1), Not studied,
ND.

ASB15,(7q31.31) Myogenesis,
E3 ligase activity: YES.

ASB16,(17q21.31), Not studied.
ND

ASB17, (1p31.1), Spermatogenesis.
ND,

ASB18, (2q37.2), not studied ,
ND.