Front Biosci (Landmark Ed). 2009 Jan 1;14:1619-26.
Poly (ADP-ribose) glycohydrolase (PARG) and its therapeutic potential.
Poly
(ADP-ribose) glycohydrolase (PARG) is a catabolic enzyme that cleaves
ADP-ribose polymers synthesized by members of the poly (ADP-ribose)
polymerase (PARP) family of enzymes. The growing evidence supports the
importance of a tight control of poly (ADP-ribose) metabolism by the two
major enzymes, PARP-1 and PARG. Recent studies have advanced the
understanding of PARPs' and PARG's functions in various cellular and
physiological processes. In the last 10 years, homeostasis of poly
(ADP-ribosyl)ation has been a target of pharmaceutical interventions for
various pathologies. Although the polymer synthesizing enzyme PARP-1
has been well studied, the function of PARG remains largely unknown.
However, a great effort has been made in recent years to delineate
biological functions of PARG and to explore the therapeutical potentials
of PARG inhibition in pathophysiological conditions such as
inflammation, ischemia, stroke, and cancer chemotherapy.PMID: 19273151 [Indexed for MEDLINE]
SMAD, PARP ja PARG :(Picture in the link)
SMAD, PARP ja PARG :(Picture in the link)
Fine-Tuning of Smad Protein
Function by Poly(ADP-Ribose) Polymerases and Poly(ADP-Ribose)
Glycohydrolase during Transforming Growth Factor β Signaling
- Published: August 18, 2014
- https://doi.org/10.1371/journal.pone.0103651
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