RNF20 (9q31.1) BRE1A, E3 ubikitiiniligaasi joka monoubitinyloi

https://www.ncbi.nlm.nih.gov/protein/NP_062538.5

 Summary: The protein encoded by this gene shares similarity with
            BRE1 of S. cerevisiae. The protein encoded by this human gene is an
            E3 ubiquitin ligase that regulates chromosome structure by
            monoubiquitinating histone H2B. This protein acts as a putative
            tumor suppressor and positively regulates the p53 tumor suppressor
            as well as numerous histone H2A and H2B genes. In contrast, this
            protein also suppresses the expression of several protooncogenes
            and growth-related genes, including many genes that are induced by
            epidermal growth factor. This gene selectively suppresses the
            expression of some genes by interfering with chromatin recruitment
            of transcription elongation factor SII (TFIIS). [provided by
            RefSeq, Feb 2012].