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måndag 13 maj 2019

OTU Deubikitinaasit (14)

  • " Gene, A20, human"
OTUD7C, A20, (6q23.3),TNFA1P3, https://www.ncbi.nlm.nih.gov/gene/7128
AISBL, , TNFA1P2, TNFalfa induced protein 5, Zn finger, ubiquiting editing and deubiquitinase ( siis ubikitiiniligaasi ja deubikitinaasifuktioinen sinkkisormiproteiini)

  • "Gene, Cezanne-1"
CEZANNE ( Cellular Zinc finger ant-NfkB protein, OTU-domain containing 7B, Zinc finger A20 domain containing protein 1Also known as ZA20D1; CEZANNE
Expression Ubiquitous expression in fat (RPKM 4.7), testis (RPKM 4.3) and 25 other tissues See more Orthologs mouse all
  • " Gene, Cezanne-2"
OTUD7A (15q12.3),OTU Deubiquitinase 7A.https://www.ncbi.nlm.nih.gov/gene/161725
C15orf16; C16ORF15; CEZANNE2
Summary The protein encoded by this gene is a deubiquitinizing enzyme and possible tumor suppressor. The encoded protein acts on TNF receptor associated factor 6 (TRAF6) to control nuclear factor kappa B expression. However, this gene is downregulated by SNAIL1 in hepatocellular carcinoma cells, contributing to their progression and malignancy. [provided by RefSeq, Aug 2016] Expression Broad expression in brain (RPKM 2.7), testis (RPKM 2.0) and 18 other tissues See more
  • "Gene, OTUD4"
OTUD4, (4q31.21), https://www.ncbi.nlm.nih.gov/gene/54726 (OTU deubiquinase 4)
Also known as HIN1; DUBA6; HSHIN1
Preferred Names OTU domain-containing protein 4
Names HIV-1 induced protein HIN-1
Summary Alternatively spliced transcript variants have been found for this gene. The smaller protein isoform encoded by the shorter transcript variant is found only in HIV-1 infected cells. [provided by RefSeq, Jul 2010] Expression Ubiquitous expression in testis (RPKM 19.7), bone marrow (RPKM 11.0) and 25 other tissues See more Orthologs mouse all
  • "Gene, HINL"
Gene type pseudo RefSeq status INFERRED Also known as HIN1L

  • "Gene OTU6A,"
Also known as DUBA2; HSHIN6
Summary Deubiquitinating enzymes (DUBs; see MIM 603478) are proteases that specifically cleave ubiquitin (MIM 191339) linkages, negating the action of ubiquitin ligases. DUBA2 belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain.[supplied by OMIM, May 2008] Orthologs mouse all
  • "Gene OTUD2"
 Preferred Names: ubiquitin thioesterase  OTU1
 Names  HIN-7, HIV-1-induced protease 7, OTU domain containing 2, OTU domain-containing protein 2, YOD1; OTU deubiquinating enzyme 1 homolog ( yeast) , hsHIN7,  DUBA8; OTUD2; PRO0907
Summary Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. The protein encoded by this gene belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013] Expression Broad expression in bone marrow (RPKM 24.5), esophagus (RPKM 15.7) and 23 other tissues See more Orthologs mouse all
  • "Gene OTUD6B"
OTUD6B (8q21.3), CGI77, DUBA5, IDDFSDA, OTU-domain containing protein 6B,
Summary This gene encodes a member of the ovarian tumor domain (OTU)-containing subfamily of deubiquitinating enzymes. Deubiquitinating enzymes are primarily involved in removing ubiquitin from proteins targeted for degradation. This protein may function as a negative regulator of the cell cycle in B cells. [provided by RefSeq, Nov 2013] Expression Ubiquitous expression in brain (RPKM 6.6), testis (RPKM 5.6) and 25 other tissues See more Orthologs mouse all

  • "Gene OTUD5"

 DUBA,
Summary This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Oct 2008] Expression Ubiquitous expression in brain (RPKM 16.1), spleen (RPKM 14.4) and 25 other tissues See more .

  • "Gene OTUB1"
Also known as OTB1; OTU1; HSPC263 Preferred Names ubiquitin thioesterase OTUB1
Names:  OTU domain, ubiquitin aldehyde binding 1 , OTU domain-containing ubiquitin aldehyde-binding protein 1, OTU-domain Ubal-binding 1, deubiquitinating enzyme OTUB1,
otubain-1, ubiquitin-specific protease otubain 1, ubiquitin-specific-processing protease OTUB1
Summary: The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Expression Ubiquitous expression in brain (RPKM 29.9), placenta (RPKM 22.0) and 25 other tissues See more Orthologs mouse all
  • "Gene OTUB2"
OTUB2 ( 14q32.12), OTB2; OTU2; C14orf137 https://www.ncbi.nlm.nih.gov/gene/78990
 Summary:  This gene encodes one of several deubiquitylating enzymes. Ubiquitin modification of proteins is needed for their stability and function; to reverse the process, deubiquityling enzymes remove ubiquitin. This protein contains an OTU domain and binds Ubal (ubiquitin aldehyde); an active cysteine protease site is present in the OTU domain. [provided by RefSeq, Aug 2011] Expression Broad expression in testis (RPKM 3.4), skin (RPKM 2.0) and 18 other tissues See more

  • " Gene OTUD1"
OTUD1 (10p12.2), DUBA7, OTDC1, https://www.ncbi.nlm.nih.gov/gene/220213
Summary Deubiquitinating enzymes (DUBs; see MIM 603478) are proteases that specifically cleave ubiquitin (MIM 191339) linkages, negating the action of ubiquitin ligases. DUBA7 belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain.[supplied by OMIM, May 2008] Orthologs mouse all
OTU deubiquitinase 1 (OTUD1) directly deubiquitinates Smad7 Protein (SMAD7) and prevents its degradation.
  • "Gene, TRABID"
ZRANB1 (10q26.13) https://www.ncbi.nlm.nih.gov/gene/54764 Also known as TRABID
Expression Ubiquitous expression in adrenal (RPKM 10.7), testis (RPKM 10.1) and 25 other tissues See more Orthologs mouse all
Preferred Names ubiquitin thioesterase ZRANB1
Names TRAF-binding domain-containing protein, TRAF-binding protein domain, hTrabid , zinc finger Ran-binding domain-containing protein 1, zinc finger, RAN-binding domain containing 1.

  • "Gene  VCPIP1"

VCPIP1 (8q13.1),https://www.ncbi.nlm.nih.gov/gene/80124, valosin containing protein interacting protein 1, DUBA3, VCIO135. Expr. Bone marrow, spleen.
Preferred Names deubiquitinating protein VCIP135
Names VCP/p47 complex-interacting 135-kDa protein, valosin-containing protein p97/p47 complex-interacting protein 1, valosin-containing protein p97/p47 complex-interacting protein p135.
https://www.ncbi.nlm.nih.gov/pubmed/25904330/







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