Semaforiinireseptorio NOV,
NOVP,
PLEXIN-A1,
PLXN1.
Se ilmenee keuhkossa, testiksessä, aivossa ja 23 muussa kudoksessa.
https://www.ncbi.nlm.nih.gov/gene/5361
Plexiini A1 prekursoripeptidi 1896 aminohappoa
https://www.ncbi.nlm.nih.gov/protein/NP_115618.3
PlexiiniA1-peptidin konservatiiviset domeenit:
- Conserved Domains (7) summary
-
- cd11271
Location:38 → 513 - Sema_plexin_A1; The Sema domain, a protein interacting module, of Plexin A1
- cd01179
Location:961 → 1046 - IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
- cd01180
Location:864 → 960 - IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
- cd01181
Location:1048 → 1148 - IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
- pfam01437
Location:514 → 556 - PSI; Plexin repeat
- pfam01833
Location:1150 → 1234 - TIG; IPT/TIG domain
- pfam08337
Location:1318 → 1866 - Plexin_cytopl; Plexin cytoplasmic RasGAP domain
- cd11271
Related articles in PubMed
- Whole Genome Sequencing of Newly Established Pancreatic Cancer Lines Identifies Novel Somatic Mutation (c.2587G>A) in Axon Guidance Receptor Plexin A1 as Enhancer of Proliferation and Invasion. Sorber R, et al. PLoS One, 2016. PMID 26962861, Free PMC Article
- PlexinA1 expression in gastric carcinoma and its relationship with tumor angiogenesis and proliferation. Zhao XY, et al. World J Gastroenterol, 2007 Dec 28. PMID 18161927, Free PMC Article
- [Expression of Plexin A1 in gastric carcinoma and its relationship with tumor angiogenesis and proliferation]. Zhao XY, et al. Zhonghua Wei Chang Wai Ke Za Zhi, 2007 May. PMID 17520388
- Inhibition of PlexA1-mediated brain tumor growth and tumor-associated angiogenesis using a transmembrane domain targeting peptide. Jacob L, et al. Oncotarget, 2016 Sep 6. PMID 27506939, Free PMC Article
- Transmembrane recognition of the semaphorin co-receptors neuropilin 1 and plexin A1: coarse-grained simulations. Aci-Sèche S, et al. PLoS One, 2014. PMID 24858828, Free PMC Article
GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?
- Data suggest that Fyn tyrosine kinase (Fyn)-dependent phosphorylation at two critical tyrosines is a key feature of vertebrate plexin A1 (PlxnA1) and plexin A2 (PlxnA2) signal transduction.
- PLEXA1 has a developmental and tumor-associated pro-angiogenic role in brain neoplasms
- We thus screened 250 patients for the presence of mutations in PLXNA1, and identified different nonsynonymous mutations (p.V349L, p.V437L, p.R528W, p.H684Y, p.G720E, p.R740H, p.R813H, p.R840Q, p.A854T, p.R897H, p.L1464V, p.K1618T, p.C1744F), all at heterozygous state, in 15 patients.
- Semaphorin-3a, neuropilin-1 and plexin-A1 are axonal guidance molecules that have been recently implicated in regulating bone metabolism.
- a novel mutation in the PLXNA1 receptor (c.2587G>A) in newly established pancreatic cell line, is reported.
- Data indicate that plexin A1-4 (PLXNA1-4) mediation of neuroanatomical traits can be detected using in vivo neuroimaging techniques.
- neuropilin 1 and plexin A1 transmembrane domains interaction
- Expression of Plexin A1 in gastric carcinoma was significantly higher than that in normal gastric mucosa.
- Data show that the expression of Sema3A receptors (neuropilin-1 (NRP-1), NRP-2, plexin A1, plexin A2, and plexin A3) significantly increased during M-CSF-mediated differentiation of monocytes into macrophages.
- Observational study of gene-disease association. (HuGE Navigator)
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