EPHA2 (1p36.13) Efriinireseptori A2

 EPHA2

https://www.ncbi.nlm.nih.gov/gene/1969

ECK; CTPA; ARCC2; CTPP1; CTRCT6

Summary

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Mutations in this gene are the cause of certain genetically-related cataract disorders.[provided by RefSeq, May 2010]

Expression

Broad expression in esophagus (RPKM 37.8), urinary bladder (RPKM 18.3) and 21 other tissues See more

Orthologs

mouse all

Preferred Names

ephrin type-A receptor 2

Names

epithelial cell receptor protein tyrosine kinase

soluble EPHA2 variant 1

tyrosine-protein kinase receptor ECK

Structure:
https://www.ncbi.nlm.nih.gov/protein/NP_004422.2https://www.ncbi.nlm.nih.gov/protein/NP_004422.2

Conserved Domains (7) summary

cd05063
Location:607 → 875

PTKc_EphR_A2; Catalytic domain of the Protein Tyrosine Kinase, Ephrin Receptor A2

cd09543
Location:902 → 971

SAM_EPH-A2; SAM domain of EPH-A2 family of tyrosine kinase receptors

smart00454
Location:902 → 968

SAM; Sterile alpha motif

cd10480
Location:28 → 201

EphR_LBD_A2; Ligand Binding Domain of Ephrin type-A Receptor 2

pfam00041
Location:438 → 519

fn3; Fibronectin type III domain

pfam07714
Location:613 → 871

Pkinase_Tyr; Protein tyrosine kinase

pfam14575
Location:556 → 608

EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

From protein and gene history:
1990: cDNA cloning and characterization of ECK, an epithelial cell receptor protein tyrosine kinase in the eph/elk family of proteins.
1994:  Activation of the ECK receptor protein-tyrosine kinase stimulates PI3K activity.
1995:  Role of B61 (later:  ephrin A1) , the ligand  for ECK receptor tyrosine kinase( later: EPHA2) , in TNFalpha induced angiogenesis.
1995:  Characterization of a novel Src-like adaptor-protein that associates with ECK RTK.
1997: ECK, a human EPH-related gene, maps to 1p36.1.
2018: Plasmodium sporozoites can invade hepatocyte cells independently of the ephrin receptor A2.
2018:  Created a novel pH-dependent  membrane peptide that  binds to EphA2 and inhibits cell  migration, named TYPE7. TYPE7 binds to EphA2 and reduces Akt phosphorylation and cell  migration as affectively as EphrinA1 (EFNA1).
2018: EphA2  is a candidate target of miR-124-3p. This microRNA inhibits Glioma cell proliferation  and motility. This microRNA was found to suppress the growth, migration and invasion of glioma cells in vitro via EphA2.
2019: Targeting EphA2 with mir-124 mediates erlotinib resistance in K-RAS mutated pancreatic cancer.  EphA2 rescued by miR-124 downregulation conferred the erlotinib resistance of pancreatic cancer cell Calpain-1 with K-RAS mutation.