Semaphorin-3B ,SEMA3B (3p21.31)

SEMA3B (3p21.31) Semaphorin 3B

Muita nimiä: SemA, SEMA5, SEMAA, SemaV, LUCA-1. Aksonin liikakasvun estäjä. Tuumorisuppressori. geeniä ilmenee istukassa, ohutsuolessa ja 20 muussa kudoksessa.

https://www.ncbi.nlm.nih.gov/gene/7869

Also known as SemA; SEMA5; SEMAA; semaV; LUCA-1

Summary. The protein encoded by this gene belongs to the class-3 semaphorin/collapsin family, whose members function in growth cone guidance during neuronal development. This family member inhibits axonal extension and has been shown to act as a tumor suppressor by inducing apoptosis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Expression. Broad expression in placenta (RPKM 31.6), small intestine (RPKM 29.6) and 20 other tissues See more

Preferred Names

semaphorin-3B

Names

sema A(V)

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B

semaphorin A

semaphorin-V

 Semaphorin -3B isoform 2 precursor , 748 a.a.

https://www.ncbi.nlm.nih.gov/protein/NP_001005914.1

(1) (2018) 

 PUBMED   29763494   GeneRIF: Advanced peri-implantitis lesions showed higher levels of
            gene expression for Sem3A and Sem4D and lower levels of Sem4A in
            comparison to tissues obtained from a healthy dental implant.

(2) (2017)

PUBMED   28581515
  REMARK    GeneRIF: data provide new insights into the role of SEMA3B in
            mammary gland and provides a new branch of GATA3 signaling that is
            pivotal for inhibition of breast cancer progression and metastasis

 (3) (2016)

 PUBMED   27349960
  REMARK    GeneRIF: By upregulating p53 and p21 expression and inhibiting Akt
            (Ser473) phosphorylation, SEMA3B could induce cell cycle arrest at
            G1/S phase.

(5) (2016)  PUBMED   27050958
  REMARK    GeneRIF: As the clinical pathological glioma grade increased,
            SEMA3B expression decreased.

Related articles in PubMed

1. Mechanism of SEMA3B gene silencing and clinical significance in glioma. Pang CH, et al. Genet Mol Res, 2016 Mar 18. PMID 27050958
2. Alteration of serum semaphorin 3B levels in preeclampsia. Wang H, et al. Clin Chim Acta, 2016 Apr 1. PMID 26828533
3. Tumor Suppressor Function of the SEMA3B Gene in Human Lung and Renal Cancers. Loginov VI, et al. PLoS One, 2015. PMID 25961819, Free PMC Article
4. Placental SEMA3B expression is not altered in severe early onset preeclampsia. Kaitu'u-Lino TJ, et al. Placenta, 2014 Dec. PMID 25454475
5. Analysis of SEMA3B methylation and expression patterns in gastric cancer tissue and cell lines. Chen R, et al. Oncol Rep, 2014 Mar. PMID 24402303
   

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

1. Maternal SEMA 3B level increased in preeclampsia before the onset of manifestations, indicating that SEMA 3B plays a role in the pathogenesis of preeclampsia
2. Aberrant expression and methylation of SEMA3B could be suggested as markers of lung and renal cancer progression.
3. although plexin-A4 overexpression restored Sema3A signaling in plexin-A1-silenced cells, it failed to restore Sema3B signaling in plexin-A2-silenced cells.
4. SEMA3B mRNA and protein is not altered in severe early onset preeclamptic placentas.
5. CpG methylation of SEMA3B epigenetically regulates SEMA3B expression during development of gastric cancer.
6. The transcriptional activity of RHOA, SEMA3B, and CKAP2 genes was assessed in blood samples of leukaemia patients and healthy donors.

 Wikipedia osoittaaa geenikohdan kuvan: https://en.wikipedia.org/wiki/SEMA3B
http://jem.rupress.org/content/jem/205/5/1155.full.pdf