Plexiineistä PLXNA2 (1q32.2)

https://www.ncbi.nlm.nih.gov/gene/5362

Also known as

OCT; PLXN2

Preferred Names

plexin-A2

Names

plexin 2

semaphorin receptor OCT

transmembrane protein OCT

Summary This gene encodes a member of the plexin-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphorins are recognized by plexin-A/neuropilin transmembrane (TM) receptor complexes, triggering a cellular signal transduction cascade that leads to axon repulsion. This plexin-A family member is thought to transduce signals from semaphorin-3A and -3C. [provided by RefSeq, Jul 2008]

Expression Ubiquitous expression in ovary (RPKM 8.4), lung (RPKM 6.9) and 23 other tissues.

 

Plexin .A2 PRECURSOR 

 https://www.ncbi.nlm.nih.gov/protein/NP_079455.3

 

Conserved Domains (7) summary

cd11272
Location:38 → 552

Sema_plexin_A2; The Sema domain, a protein interacting module, of Plexin A2

cd01179
Location:954 → 1037

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:858 → 953

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01181
Location:1041 → 1141

IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:806 → 855

PSI; Plexin repeat

pfam01833
Location:1143 → 1227

TIG; IPT/TIG domain

pfam08337
Location:1311 → 1864

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

Related articles in PubMed

1. Rare copy number variations in adults with tetralogy of Fallot implicate novel risk gene pathways. Silversides CK, et al. PLoS Genet, 2012. PMID 22912587, Free PMC Article
2. Identification of the semaphorin receptor plexin-A2 as a candidate gene for susceptibility to ankylosing spondylitis. Chatzikyriakidou A, et al. Clin Exp Rheumatol, 2011 Sep-Oct. PMID 22011406
3. Multicenter, randomized, double-blind, active comparator and placebo-controlled trial of a corticotropin-releasing factor receptor-1 antagonist in generalized anxiety disorder. Coric V, et al. Depress Anxiety, 2010 May. PMID 20455246
4. No association between schizophrenia and polymorphisms of the PlexinA2 gene in Chinese Han Trios. Budel S, et al. Schizophr Res, 2008 Feb. PMID 18096369, Free PMC Article
5. Genetic examination of the PLXNA2 gene in Japanese and Chinese people with schizophrenia. Takeshita M, et al. Schizophr Res, 2008 Feb. PMID 18065206

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

1. Data suggest that Fyn tyrosine kinase (Fyn)-dependent phosphorylation at two critical tyrosines is a key feature of vertebrate plexin A1 (PlxnA1) and plexin A2 (PlxnA2) signal transduction.
2. Data indicate that plexin A1-4 (PLXNA1-4) mediation of neuroanatomical traits can be detected using in vivo neuroimaging techniques.
3. although plexin-A4 overexpression restored Sema3A signaling in plexin-A1-silenced cells, it failed to restore Sema3B signaling in plexin-A2-silenced cells.
4. PLXNA2 upregulation contributes to TMPRSS2:ERG-mediated enhancements of PC3c cell migration and invasion.
5. PLXNA2 has been identified as a new rare copy number variations gene for tetralogy of Fallot.
6. results of our study reveal that PlxnA2 has a pro-osteogenic function by modulating BMP2 signaling
7. PLXNA2 polymorphisms show association with ankylosing spondylitis.
8. in vitro analysis of PLXNA2 revealed that the gene has higher expression in more aggressive breast cancer cell types.

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