Leta i den här bloggen


tisdag 5 mars 2019

Plexin-B1, PLXNB1 (3p21.31)

 https://www.ncbi.nlm.nih.gov/gene/5364

PLXNB1 

Also known as
SEP; PLXN5; PLEXIN-B1
Expression
Ubiquitous expression in skin (RPKM 13.8), kidney (RPKM 13.0) and 24 other tissues See more

Preferred Names
plexin-B1
Names
plexin 5
semaphorin receptor SEP

  XP_011532137.1  plexin-B1 isoform X1

Conserved Domains (8) summary
cd11275
Location:28480
Sema_plexin_B1; The Sema domain, a protein interacting module, of Plexin B1
smart00423
Location:641677
PSI; domain found in Plexins, Semaphorins and Integrins
cd01179
Location:11621249
IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
cd01180
Location:10701161
IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
cd01181
Location:12521376
IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
pfam01437
Location:481527
PSI; Plexin repeat
pfam08337
Location:15622103
Plexin_cytopl; Plexin cytoplasmic RasGAP domain
cl26464
Location:681839   (serine,  proline rich )
Atrophin-1; Atrophin-1 family
Atrophin-1 family
Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteristic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.

Related articles in PubMed

Inga kommentarer:

Skicka en kommentar