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tisdag 5 mars 2019

Ubikitiiniligaasi FBXO6 on SCF( Skp1-Cullin-F-box) E3-ubikitiiniligaasiperhettä

https://pubs.acs.org/doi/10.1021/pr2010204
Alternative titles; symbols

FBX6
F-BOX/G-DOMAIN PROTEIN 2; FBG2

HGNC Approved Gene Symbol: FBXO6
Cytogenetic location: 1p36.22     Genomic coordinates (GRCh38): 1:11,664,092-11,674,353 (from NCBI)

TEXT

Description 

The F box, named after cyclin F (CCNF; 600227), in which it was originally observed, is an approximately 40-amino acid motif that binds SKP1 (601434). F-box proteins, such as FBXO6, are components of modular E3 ubiquitin protein ligases called SCFs (SKP1, cullin (see 603134), F-box proteins), which function in phosphorylation-dependent ubiquitination.



2004 Nov 29;1695(1-3):133-70.

A hitchhiker's guide to the cullin ubiquitin ligases: SCF and its kin.

Abstract

The SCF (Skp1-Cullin-F-box) E3 ubiquitin ligase family was discovered through genetic requirements for cell cycle progression in budding yeast. In these multisubunit enzymes, an invariant core complex, composed of the Skp1 linker protein, the Cdc53/Cul1 scaffold protein and the Rbx1/Roc1/Hrt1 RING domain protein, engages one of a suite of substrate adaptors called F-box proteins that in turn recruit substrates for ubiquitination by an associated E2 enzyme. The cullin-RING domain-adaptor architecture has diversified through evolution, such that in total many hundreds of distinct SCF and SCF-like complexes enable degradation of myriad substrates. Substrate recognition by adaptors often depends on posttranslational modification of the substrate, which thus places substrate stability under dynamic regulation by intracellular signaling events. SCF complexes control cell proliferation through degradation of critical regulators such as cyclins, CDK inhibitors and transcription factors. A plethora of other processes in development and disease are controlled by other SCF-like complexes, including those based on Cul2-SOCS-box adaptor protein and Cul3-BTB domain adaptor protein combinations. Recent structural insights into SCF-like complexes have begun to illuminate aspects of substrate recognition and catalytic reaction mechanisms.
PMID:
15571813
DOI:
10.1016/j.bbamcr.2004.09.027

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