Alternative titles; symbols
FBX6
F-BOX/G-DOMAIN PROTEIN 2; FBG2
HGNC Approved Gene Symbol: FBXO6
Cytogenetic location: 1p36.22
Genomic coordinates (GRCh38): 1:11,664,092-11,674,353
(from NCBI)
TEXT
▼ Description
Biochim Biophys Acta. 2004 Nov 29;1695(1-3):133-70.
A hitchhiker's guide to the cullin ubiquitin ligases: SCF and its kin.
Abstract
The
SCF (Skp1-Cullin-F-box) E3 ubiquitin ligase family was discovered
through genetic requirements for cell cycle progression in budding
yeast. In these multisubunit enzymes, an invariant core complex,
composed of the Skp1 linker protein, the Cdc53/Cul1 scaffold protein and
the Rbx1/Roc1/Hrt1 RING domain protein, engages one of a suite of
substrate adaptors called F-box proteins that in turn recruit substrates
for ubiquitination by an associated E2 enzyme. The cullin-RING
domain-adaptor architecture has diversified through evolution, such that
in total many hundreds of distinct SCF and SCF-like complexes enable
degradation of myriad substrates. Substrate recognition by adaptors
often depends on posttranslational modification of the substrate, which
thus places substrate stability under dynamic regulation by
intracellular signaling events. SCF complexes control cell proliferation
through degradation of critical regulators such as cyclins, CDK
inhibitors and transcription factors. A plethora of other processes in
development and disease are controlled by other SCF-like complexes,
including those based on Cul2-SOCS-box adaptor protein and Cul3-BTB
domain adaptor protein combinations. Recent structural insights into
SCF-like complexes have begun to illuminate aspects of substrate
recognition and catalytic reaction mechanisms.
- PMID:
- 15571813
- DOI:
- 10.1016/j.bbamcr.2004.09.027
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