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tisdag 12 mars 2019

EFRIINIT ja Efriinireseptorit (Eph)


  • Ephrins

Efriner

Svensk definition

Signalproteiner som verkar som ligander för EPH-familjens receptorer. De utgörs av membranbundna proteiner fästa vid cellmembranet antingen via en glykoinositolfosfolipidförankring eller genom en transmembrandomän. Många efriner anses vara viktiga signalmolekyler celler emellan vilka kontrollerar morfologisk utveckling under embryobildningen.

Engelsk definition

Signaling proteins that are ligands for the EPH FAMILY RECEPTORS. They are membrane-bound proteins that are attached to the CELL MEMBRANE either through a GLYCOINOSITOL PHOSPHOLIPID MEMBRANE ANCHOR or through a transmembrane domain. Many of the ephrins are considered important intercellular signaling molecules that control morphogenic changes during embryogenesis.
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EPHA1-RESEPTORI-joukko on laaja perhe  reseptoriproteiini-tyrosiinikinaaseja, jotka  ovat keskenään rakenteellisesti  sukua.  tämän proteiiniperheen nimi juontuu alkuperäisestä Eph_ proteiinista. Nykään niitä sanotaan EPHA1-reseptoreiksi. Ne on nimetty sen solulinjan mukaan, joista ne ensiksi löydettiin: Erytropoietiinia tuottava  ihmisen hepatosellulaarisen syövän solulinja (Erythropoietin-Producing human Hepatocellular carcinoma cell line). Tämän perheen jäsenet  osallistuvat  sellaisten solu-solu-vuorovaikutusten säätelyyn, joita esiintyy  hermojärjestelmän mallin muodostumisessa ja kehittymisessä.  

Reseptorit EphA1- EphA7, EphB1- EphB6

  • Receptors, Eph Family

Eph-receptorer

Engelsk definition

A large family of receptor protein-tyrosine kinases that are structurally-related. The name of this family of proteins derives from original protein Eph (now called the EPHA1 RECEPTOR), which was named after the cell line it was first discovered in: Erythropoietin-Producing human Hepatocellular carcinoma cell line. Members of this family have been implicated in regulation of cell-cell interactions involved in nervous system patterning and development.
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Bredare termer

Snävare termer

I hierarkin

  1. Enzymes and Coenzymes
  2. Enzymes
  3. Transferases
  4. Phosphotransferases
  5. Phosphotransferases (Alcohol Group Acceptor)
  6. Protein Kinases
  7. Protein-Tyrosine Kinases
  8. Receptor Protein-Tyrosine Kinases
  9. Receptors, Eph Family
  1. Amino Acids, Peptides, and Proteins
  2. Proteins
  3. Membrane Proteins
  4. Receptors, Cell Surface
  5. Receptor Protein-Tyrosine Kinases
  6. Receptors, Eph Family

Bredare termer

Snävare termer

I hierarkin

  1. Amino Acids, Peptides, and Proteins
  2. Peptides
  3. Intercellular Signaling Peptides and Proteins
  4. Ephrins
  1. Amino Acids, Peptides, and Proteins
  2. Proteins
  3. Intercellular Signaling Peptides and Proteins
  4. Ephrins
  1. Amino Acids, Peptides, and Proteins
  2. Proteins
  3. Membrane Proteins
  4. Ephrins
  1. Biological Factors
  2. Intercellular Signaling Peptides and Proteins
  3. Ephrins
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