PLXD1
Plexin-D1
Precursor 1925 a.a.
N-glykosylations at least 18.
https://www.ncbi.nlm.nih.gov/protein/NP_055918.2
Conserved Domains (7) summary
- cd11247
Location:49 → 547 - Sema_plexin_D1; The Sema domain, a protein interacting module, of Plexin D1
- smart00423
Location:711 → 753 - PSI; domain found in Plexins, Semaphorins and Integrins
- cd01179
Location:981 → 1067 - IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
- cd01180
Location:891 → 979 - IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
- cd01181
Location:1069 → 1174 - IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
- pfam01437
Location:549 → 601 - PSI; Plexin repeat
- pfam08337
Location:1345 → 1888 - Ple
Related articles in PubMed
- Isolated truncus arteriosus associated with a mutation in the plexin-D1 gene. Ta-Shma A, et al. Am J Med Genet A, 2013 Dec. PMID 24254849
- Plexin D1: new potential biomarker for cervical cancer. Shalaby MA, et al. J Immunoassay Immunochem, 2012. PMID 22738647
- Plexin D1 is ubiquitously expressed on tumor vessels and tumor cells in solid malignancies. Roodink I, et al. BMC Cancer, 2009 Aug 25. PMID 19703316, Free PMC Article
- Sequence analysis of the PLEXIN-D1 gene in Möbius syndrome patients. van der Zwaag B, et al. Pediatr Neurol, 2004 Aug. PMID 15301830
- An Electrical Impedance-Based Method for Quantitative Real-Time Analysis of Semaphorin-Elicited Endothelial Cell Collapse. Camillo C, et al. Methods Mol Biol, 2017. PMID 27787852
eRIFs: Gene References Into FunctionsWhat's a GeneRIF?
- the receptor Plexin-D1 contains a sorting motif that interacts with the adaptor protein GIPC1 to facilitate transport to recycling endosomes.
- SNPs associated with type 2 diabetes and obesity may also increase the risk of developing gestational diabetes mellitus (GDM) in the Chinese population. Among these SNPs, we report for the first time that rs945508 in ARHGEF11, rs10804591 in PLXND1 and rs10245353 in NFE2L3 were associated with GDM.
- Authors found that the PlexinD1 cleavage product binds to actin rods, pathological aggregate-like structures which had so far been described for age-related neurodegenerative diseases. Data suggest a novel disease mechanism for SMA involving formation of actin rods as a molecular sink for a cleaved PlexinD1 fragment leading to dysregulation of receptor signaling.
- Measuring electrical impedance allows real-time monitoring of changes in endothelial cell morphology and adhesion induced by SEMA3E via plexin D1
- Plexin D1 plays a role in collagen contraction in human lung fibroblasts.
- Findings suggest that Plexin-D1/class III semaphorin (Sema3E) axis is triggered in systemic sclerosis (SSc) endothelium .https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546224/bin/13075_2015_749_Fig1_HTML.jpg
- finding that PLXND1 and REV3L mutations are responsible for a proportion of MBS patients suggests that de novo mutations in other genes might account for other MBS patients
- The data indicate that Plexin-D1 operates in a cell context-specific fashion, mediating different synaptogenic outcomes depending upon neuron type.
- Plxnd1 is a novel regulator of VAT growth, body fat distribution, and insulin sensitivity in both zebrafish and humans
- The identification and characterization of SH3BP1 as a novel downstream effector of Sema3E-PlexinD1 provides an explanation for how extracellular signals are translated into cytoskeletal changes and unique cell behavior.
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