E3 Ubikitiiniligaasikompleksi SCF(SKP1-cullin-F-box):: FBXW11 , fosforylaatiosta riippuva ubikitinaatio

 Tämän ubikitiiniligaasin  kohdemolekyyli, jonka se ubikitinoi ja johtaa silppuriin on  ZNF281, jonka yhteydessä huomaan sen. Kloonattu 2000.

FBXW11 (5q35.1), https://www.ncbi.nlm.nih.gov/gene/23291

Also known as Hos; BTRC2; FBW1B; Fbw11; BTRCP2; FBXW1B

Summary This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons. [provided by RefSeq, Jul 2008]

Expression Ubiquitous expression in brain (RPKM 22.1), heart (RPKM 11.8) and 25 other tissues See more Orthologs mouse all

Preferred Names

F-box/WD repeat-containing protein 11

Names

F-box and WD repeats protein beta-TrCP2

F-box and WD-40 domain protein 11

F-box and WD-40 domain protein 1B

F-box protein Fbw1b

F-box/WD repeat-containing protein 1B

beta-transducin repeat-containing protein 2

homologous to Slimb protein

 

Related articles in PubMed

1. Holoprosencephaly and preaxial polydactyly associated with a 1.24 Mb duplication encompassing FBXW11 at 5q35.1. Koolen DA, et al. J Hum Genet, 2006. PMID 16865294
2. Molecular cloning and genomic structure of the betaTRCP2 gene on chromosome 5q35.1. Koike J, et al. Biochem Biophys Res Commun, 2000 Mar 5. PMID 10694485
3. Model of the Interaction between the NF-κB Inhibitory Protein p100 and the E3 Ubiquitin Ligase β-TrCP based on NMR and Docking Experiments. Melikian M, et al. J Chem Inf Model, 2017 Feb 27. PMID 28004927
4. Specificity, location and function of βTrCP isoforms and their splice variants. Putters J, et al. Cell Signal, 2011 Apr. PMID 21138764
5. Negative regulation of prolactin receptor stability and signaling mediated by SCF(beta-TrCP) E3 ubiquitin ligase. Li Y, et al. Mol Cell Biol, 2004 May. PMID 15082796, Free PMC Article

GeneRIFs: Gene References Into Functions

1. beta-TrCP was identified as a novel interacting partner of ASK1 that is capable of ubiquitinating and degrading ASK1 through the ubiquitin-proteasome system. These findings suggest that beta-TrCP is capable of suppressing oxidative stress-induced caspase 3-dependent apoptosis through suppression of ASK1.
2. SCF(FBXW11) bound, polyubiquitylated, and destabilized RAPGEF2, a guanine nucleotide exchange factor that activates the small GTPase RAP1
3. Data indicate that miR-106b-25 cluster (miR-106b, miR-93 and miR-25) targets the 3'UTR of the beta-TRCP2 transcript and increases the expression of Snail.
4. Knockdown of beta-TrCP1 and beta-TrCP2 attenuated the K48-linked ubiquitination and degradation of IRAK1.
5. two splice variants of beta-transducin repeat containing protein 2 (BTRCP2) localise exclusively to either the nucleus or the cytosol.
6. Data indicate that knockdown of beta-TrCP1 and beta-TrCP2 markedly reduced IL-17-induced, phosphorylation-dependent ubiquitination and degradation of Act1.
7. FBXW11 may be the most likely candidate gene for the Holoprosencephaly and prexial polydactyly phenotype.

  ZNF281 ( onkogeeni)  indusoituu SNAIL:sta ja ubikitonoituu ja johtuu silppuriin  tästä otsikon E3 ubikitiiniligaasista, joka vaatii fosforylaation.  

Muistiin 4.6. 2019.