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måndag 1 oktober 2018

Nobelpalkinto lääketieteestä ja fysiologiasta professoreille Tasuko Honjo ja James P Allison.

Etsin professori Tasuko Honjon artikkelita PubMed hakulaiteella. löytyy 180 ja otan niistä sitaatin  20  viimeisimmästä. 
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1.
PPAR-induced fatty acid oxidation in T cells increases the number of tumor-reactive CD8+ T cells and facilitates anti-PD-1 therapy.
Chowdhury PS, Chamoto K, Kumar A, Honjo T.
Cancer Immunol Res. 2018 Aug 24. pii: canimm.0095.2018. doi: 10.1158/2326-6066.CIR-18-0095. [Epub ahead of print]
Although PD-1 blockade cancer immunotherapy has shown potential for a wide range of cancer patients, its efficacy is limited, in part, due to the loss of effector cytotoxic T lymphocytes (CTLs) via terminal differentiation-induced apoptosis. We previously demonstrated that mitochondrial activation, by the agonists of peroxisome proliferator-activated receptor γ (PPARγ) coactivator 1-α (PGC-1α/transcription factor complexes, had synergistic effects with a PD-1-blocking monoclonal antibody (mAb) in a mouse tumor model. In the current study, we examined the molecular mechanism of the synergistic effects of bezafibrate, an agonist of PGC-1α/ PPAR complexes, which enhanced the tumoricidal effects of PD-1 blockade. Bezafibrate activated CTL mitochondria and upregulated oxidative phosphorylation as well as glycolysis, resulting in more proliferation of naïve T cells and improved effector function in CTLs. Bezafibrate also increased fatty acid oxidation (FAO) and mitochondrial respiratory capacity, which supports the extra energy demands of cells in emergencies, allowing cell survival. Carnitine palmitoyl transferase 1 (Cpt1), which is needed for FAO, and Bcl2 were both upregulated. Cpt1 and Bcl2 can form a complex to prevent apoptosis of CTLs. Together, these results indicate that bezafibrate increases or maintains the number of functional CTLs by activating mitochondrial and cellular metabolism, leading in turn to enhanced antitumor immunity during PD-1 blockade.
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2.
Depletion of recombination-specific cofactors by the C-terminal mutant of the activation-induced cytidine deaminase causes the dominant negative effect on class switch recombination.
Al Ismail A, Husain A, Kobayashi M, Honjo T, Begum NA.
Int Immunol. 2017 Dec 30;29(11):525-537. doi: 10.1093/intimm/dxx061.
PMID:
29136157
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3.
Metabolic shift induced by systemic activation of T cells in PD-1-deficient mice perturbs brain monoamines and emotional behavior.
Miyajima M, Zhang B, Sugiura Y, Sonomura K, Guerrini MM, Tsutsui Y, Maruya M, Vogelzang A, Chamoto K, Honda K, Hikida T, Ito S, Qin H, Sanuki R, Suzuki K, Furukawa T, Ishihama Y, Matsuda F, Suematsu M, Honjo T, Fagarasan S.
Nat Immunol. 2017 Dec;18(12):1342-1352. doi: 10.1038/ni.3867. Epub 2017 Oct 23.
PMID:
29058703
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4.
Accelerated Systemic Autoimmunity in the Absence of Somatic Hypermutation in 564Igi: A Mouse Model of Systemic Lupus with Knocked-In Heavy and Light Chain Genes.
McDonald G, Medina CO, Pilichowska M, Kearney JF, Shinkura R, Selsing E, Wortis HH, Honjo T, Imanishi-Kari T.
Front Immunol. 2017 Sep 13;8:1094. doi: 10.3389/fimmu.2017.01094. eCollection 2017.
PMID:
28955333
Free PMC Article
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5.
Role of PD-1 in Immunity and Diseases.
Chamoto K, Al-Habsi M, Honjo T.
Curr Top Microbiol Immunol. 2017;410:75-97. doi: 10.1007/82_2017_67.
PMID:
28929192
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6.
Cancer immunotherapies targeting the PD-1 signaling pathway.
Iwai Y, Hamanishi J, Chamoto K, Honjo T.
J Biomed Sci. 2017 Apr 4;24(1):26. doi: 10.1186/s12929-017-0329-9. Review.
PMID:
28376884
Free PMC Article
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7.
The novel activation-induced deoxycytidine deaminase (AID) mutants, AIDv and AIDvΔ15 are defective in SHM and CSR.
Kobayashi M, Takemoto M, Honjo T.
DNA Repair (Amst). 2017 May;53:1-3. doi: 10.1016/j.dnarep.2017.02.015. Epub 2017 Mar 6. No abstract available.
PMID:
28292632
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8.
Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity.
Chamoto K, Chowdhury PS, Kumar A, Sonomura K, Matsuda F, Fagarasan S, Honjo T.
Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):E761-E770. doi: 10.1073/pnas.1620433114. Epub 2017 Jan 17.
PMID:
28096382
Free PMC Article
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9.
Erratum to: Role of PD-1 in Immunity and Diseases.
Chamoto K, Al-Habsi M, Honjo T.
Curr Top Microbiol Immunol. 2017;410:E1. doi: 10.1007/978-3-319-68929-6_69. No abstract available.
PMID:
29492725
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10.
Nonoverlapping roles of PD-1 and FoxP3 in maintaining immune tolerance in a novel autoimmune pancreatitis mouse model.
Zhang B, Chikuma S, Hori S, Fagarasan S, Honjo T.
Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):8490-5. doi: 10.1073/pnas.1608873113. Epub 2016 Jul 7.
PMID:
27410049
Free PMC Article
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11.
Functional requirements of AID's higher order structures and their interaction with RNA-binding proteins.
Mondal S, Begum NA, Hu W, Honjo T.
Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):E1545-54. doi: 10.1073/pnas.1601678113. Epub 2016 Feb 29.
PMID:
26929374
Free PMC Article
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12.
Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability.
Husain A, Begum NA, Taniguchi T, Taniguchi H, Kobayashi M, Honjo T.
Nat Commun. 2016 Feb 4;7:10549. doi: 10.1038/ncomms10549.
PMID:
26842758
Free PMC Article
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13.
Safety and Antitumor Activity of Anti-PD-1 Antibody, Nivolumab, in Patients With Platinum-Resistant Ovarian Cancer.
Hamanishi J, Mandai M, Ikeda T, Minami M, Kawaguchi A, Murayama T, Kanai M, Mori Y, Matsumoto S, Chikuma S, Matsumura N, Abiko K, Baba T, Yamaguchi K, Ueda A, Hosoe Y, Morita S, Yokode M, Shimizu A, Honjo T, Konishi I.
J Clin Oncol. 2015 Dec 1;33(34):4015-22. doi: 10.1200/JCO.2015.62.3397. Epub 2015 Sep 8.
PMID:
26351349
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14.
[112th Scientific Meeting of the Japanese Society of Internal Medicine: Special Lecture: Cancer Immunotherapy by PD-1 Antibody].
Honjo T.
Nihon Naika Gakkai Zasshi. 2015 Sep;104(9):1917. Japanese. No abstract available.
PMID:
30160898
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15.
Identification of DNA cleavage- and recombination-specific hnRNP cofactors for activation-induced cytidine deaminase.
Hu W, Begum NA, Mondal S, Stanlie A, Honjo T.
Proc Natl Acad Sci U S A. 2015 May 5;112(18):5791-6. doi: 10.1073/pnas.1506167112. Epub 2015 Apr 20.
PMID:
25902538
Free PMC Article
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16.
APE1 is dispensable for S-region cleavage but required for its repair in class switch recombination.
Xu J, Husain A, Hu W, Honjo T, Kobayashi M.
Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):17242-7. doi: 10.1073/pnas.1420221111. Epub 2014 Nov 17.
PMID:
25404348
Free PMC Article
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17.
Opinion: uracil DNA glycosylase (UNG) plays distinct and non-canonical roles in somatic hypermutation and class switch recombination.
Yousif AS, Stanlie A, Begum NA, Honjo T.
Int Immunol. 2014 Oct;26(10):575-8. doi: 10.1093/intimm/dxu071. Epub 2014 Jul 3. Review.
PMID:
24994819
Free PMC Article
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18.
Chromatin reader Brd4 functions in Ig class switching as a repair complex adaptor of nonhomologous end-joining.
Stanlie A, Yousif AS, Akiyama H, Honjo T, Begum NA.
Mol Cell. 2014 Jul 3;55(1):97-110. doi: 10.1016/j.molcel.2014.05.018. Epub 2014 Jun 19.
PMID:
24954901
Free Article
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19.
Differential regulation of S-region hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylase.
Yousif AS, Stanlie A, Mondal S, Honjo T, Begum NA.
Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):E1016-24. doi: 10.1073/pnas.1402391111. Epub 2014 Mar 3.
PMID:
24591630
Free PMC Article
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20.
Activation-induced cytidine deaminase is dispensable for virus-mediated liver and skin tumor development in mouse models.
Nguyen T, Xu J, Chikuma S, Hiai H, Kinoshita K, Moriya K, Koike K, Marcuzzi GP, Pfister H, Honjo T, Kobayashi M.
Int Immunol. 2014 Jul;26(7):397-406. doi: 10.1093/intimm/dxu040. Epub 2014 Feb 25.
PMID:
24569264
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