Staufen
(Stau) proteins belong to a family of RNA-binding proteins (RBPs) that
are important for RNA localisation in many organisms. In this review we
discuss recent findings on the conserved role played by Stau during both
the early differentiation of neurons and in the synaptic plasticity of
mature neurons. Recent molecular data suggest mechanisms for how Stau2
regulates mRNA localisation, mRNA stability, translation, and
ribonucleoprotein (RNP) assembly. We offer a perspective on how this
multifunctional RBP has been adopted to regulate mRNA localisation under
several different cellular and developmental conditions.
Keywords: RNA localisation, Staufen, neurogenesis, synaptic plasticity, RNP, mRNA stability, learning and memory
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