AAS
Per
Arne
Macromolecular
maintenance in human cells- Repair ( of uracil in DNA and)
methylations in DNA (and RNA ) (Theses) NTNU 2004 Norwegian Cancer
Society.
Suluissa
mainituista asioista ( kohdat 4. ja 5.) eri kommentit lähetetty
edeltä.
Sisällysluettelo
1.
Eräitä tärkeitä lyhennyksiä, Abbreviations
2.
Johdanto.
3.
Overview of DNA repair mechanism
Direct
reversal ( neljä eri järjestelmää)
Base
excision repair (BER)
(4.
Urasil in DNA
Uracil
DNA glycosylase encoded by the UNG gene
Catalytic
mechanism of uracil DNA glycosylse (UNG)
Structure
of the UNG gene, localisation of UNG and protein:protein interaction
Regulation
of UNG expression- background and some results
The
role of UNG in the maturation of antibodies)
Nucleotide
excision repair (NER)
Mismatch
repair (MMR)
Double
strand break repair (DSB)
Bypass
of damage in human cells
Transcription
regulation
Repair
of alkylation damage by the hiuman AlkB homologues-background,some
resultr and coments
The
Ada regulon in .coli
Exogenous
and endogenous sources of alkylation damage
(5.
RNA repair and quality control of RNA
Normal
modifications in tRNA and rRNA
Protein
repair
Tiedemiehen P A Aasin kirjassa esiintyneet tavallisimmat lyhennykset kirjan tavallisimmat lyhennykset
AAG,
alkyladenine glycosylase = ANPG = MPG.
AID,
activation induced deaminase.
AGT,
O-alkylguanine-DNA-transferase AGT=AGAT=MGMT.
AGAT,
O-alkylguanine-DNA transferase.
ANPG,
alkyl-B-purine glycosylase.
ATM,
Ataxia Teleangiectasia Mutated.
ATR, Ataxia Teleangiectasia Related.
BER, Base Excision Repair.
bp,
base pair.
CS,
Cockayne syndrome.
CSR, Cass Switch Recombination.
5,6-
dihydrouracil.
dRB,
deoxyribophosphate.
DSBR, Double Strand Break Repair.
dsDNA, double stranded DNA.
dUTPase,
desoxyuridine triphosphate hydrolase.
ERCC1, Excision Repair Cross-Complementing 1.
EST,
Expressed Sequence Tag.
FEN-1, Flap Endonuclease 1.
5-foU,
5-Formyluracil.
5-FU,
5 -Fluorouracil.
GG-NER,
Global Genome Nucleotide Excision Repair.
HAP1,
Human AP-endonuclease.
hABH1,
human AlkB homologue 1.
hABH2,
human AlkB homolohgue 2.
hABH3,
human AlkB homologue 3.
HAT, Histone Acetyl Transferase.
HDAC, Histone Deacetylase
5-HMU,
5-Hydroxymethyluracil.
HMT, Histone Methyl transferase.
HR, Homologous Recombination.
kb, kilobase.
kDa, kilo Dalton.
MBD4, Methyl-Binding Domain protein 4.
MCMT,
5 -Methylcytosine Methyl transferase.
1-meA,
1-methyladenine.
3-meA, 3- methyladenine.
3-meC,
3-methylcytosine.
5-meC,
5-methylcytosine.
3-meG,
3-methylguaninhe.
7-meG, 7-methylguanine.
MGMT,
O-methylguanine-DNA-transferase.
MMR, Mismatch Repair.
MPG, Methylpurine Glycosylase.
mRNA,
messengerRNA.
MUG,
Mismatch specific Uracil-DNA Glycosylase.
MSI,
micro satellite instability.
NBS,
Nijmeken Breakage Syndrome.
NHEJ,
Non -Homologous End Joining.
NMD, Nonsence Mediated Decay.
nt,
nucleotide.
2-OHA,
2- Hydroxyadenine.
2-OHC, 2-Hydroxycytosine.
2-OHU, 2-Hydroxyuracil.
O-meG,
O-methylguanine.
O-meT, O-methylthymine.
8-oxoG,
8-oxo-7, 8-dihydroguanine.
P
A and P B, promoter A, Promotor B.
PARP,
Poly (ADP-ribose) Polymerase.
PCNA, Proliferating Cell Nuclear Antigen.
PCR, Polymerase Chain Reaction.
PTM,
Post Transcriptional Modification.
RPA,
Replication protein A.
SAM,
S-Adenosyl Methionin.
SHM, Somatic HyperMutation.
SMUG-1,
single-strand-Selective Monofunctional Uracil-DNA Glycosylase 1.
ssBP,
single strand Binding Protein.
ssDNA,
single stranded DNA.
TCR, Transcription Coupled Repair.
TC-NER, TC- Nucleotide Excision Repair
TdT, Terminal deoxynucleotidyl Transferase.
TFIIH, Transcription Factor IIH.
TTD,
Tricothiodystrophia.
UDG, Uracil-DNA Glycosylase.
UNG1,
mitochondrial form of Uracil-DNA-Glycosylase.
UNG2,
nuclear form of uracil-DNA-glycosylase ( urasiilin poistajat DNA:sta)
Vif,
virion infectivity factor.
XP,
Xeroderma Pigmentosum.
XRCC1,
eräs osin tuntematon proteiini, joka koordinoi BER- systeemin
aktivaatioproteiineja.
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