- ZBTB7C, https://www.ncbi.nlm.nih.gov/gene/201501
- Official Symbol
- ZBTB7C
- Official Full Name
- zinc finger and BTB domain containing 7C
- Also known as
- APM1; APM-1; ZBTB36; ZNF857C
- Expression
- Broad expression in esophagus (RPKM 8.6), skin (RPKM 4.3) and 18 other tissues See more
- Orthologs mouse al
- Characterization of a novel human papillomavirus DNA in the cervical carcinoma cell line ME180. Reuter S, et al. J Virol, 1991 Oct. PMID 1716694, Free PMC Article
- Kr-POK (ZBTB7c) regulates cancer cell proliferation through glutamine metabolism. Hur MW, et al. Biochim Biophys Acta Gene Regul Mech, 2017 Aug. PMID 28571744
-
Integrative Mouse and Human Studies Implicate ANGPT1 and ZBTB7C as Susceptibility Genes to Ischemic Injury.
Du R, et al. Stroke, 2015 Dec. PMID 26542693, Free PMC Article CONCLUSIONS: Genetic variations of ANGPT1 and ZBTB7C are
associated with increased infarct size in both mice and humans. ZBTB7C
may modulate the ischemic response via neuronal apoptosis and dynamic
collateralization and, in addition to ANGPT1, may serve as potential
novel targets for treatments of cerebral ischemia.
- Adrenomedullin and adrenomedullin binding protein-1 protect endothelium-dependent vascular relaxation in sepsis. Zhou M, et al. Mol Med, 2007 Sep-Oct. PMID 17932560, Free PMC Article Abstract
- APM-1, a novel human gene, identified by aberrant co-transcription with papillomavirus oncogenes in a cervical carcinoma cell line, encodes a BTB/POZ-zinc finger protein with growth inhibitory activity. Reuter S, et al. EMBO J, 1998 Jan 2. PMID 9427755, Free PMC Article
GeneRIFs: Gene References Into Functions
What's a GeneRIF?
- Repression of Kr-POK inhibited tumor growth.
- ZBTB7C genetic variations were significant for susceptibility to ischemic injury in cerebral ischemia.
- our findings define KR-POK as a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function.
Inga kommentarer:
Skicka en kommentar