ZBTB2 (6q25.1), ZNF437. p21 repressori ja p53 mestarisäätelijä

ZBTB2 (ZNF437)  (6q25.1)
Ilmentyy kilpirauhasewssa, imusolmukkeessa ja 25 muussa kudoksessa.
https://www.ncbi.nlm.nih.gov/gene/57621

1. DNA binding of the p21 repressor ZBTB2 is inhibited by cytosine hydroxymethylation. Lafaye C, et al. Biochem Biophys Res Commun, 2014 Mar 28. PMID 24607898
2. LncRNA CALML3-AS1 promotes tumorigenesis of bladder cancer via regulating ZBTB2 by suppression of microRNA-4316. Wang F, et al. Biochem Biophys Res Commun, 2018 Sep 26. PMID 30177388
3. ZBTB2, a novel master regulator of the p53 pathway. Jeon BN, et al. J Biol Chem, 2009 Jul 3. PMID 19380588, Free PMC Article
4. ZBTB2 increases PDK4 expression by transcriptional repression of RelA/p65. Kim MY, et al. Nucleic Acids Res, 2015 Feb 18. PMID 25609694, Free PMC Article
5. A genome-wide association study identifies novel loci associated with susceptibility to chronic myeloid leukemia. Kim DH, et al. Blood, 2011 Jun 23. PMID 21540461

See all (26) citations in PubMed

 NP_065912.1  zinc finger and BTB domain-containing protein 2

ORIGIN      
        1 mdlanhglil lqqlnaqref gflcdctvai gdvyfkahks vlasfsnyfk mlfvhqtsec
       61 vrlkptdiqp difsyllhlm ytgkmapqli dpvrleqgik flhaypliqe aslasqgafs
      121 hpdqvfplas slygiqiadh qlrqatkias apeklgrdpr pqtsrisqeq vpeasqlsql
      181 tsnlaqvnrt nmtpsdplqt slspelvstp vpppppgeet nleasssdeq pasltiahvk
      241 psimkrngsf pkyyachlcg rrftlrsslr ehlqihtgvp ftssqqgesr vpltlcsnaa
      301 dlgkdamevp eagmisdsel qhisdspiid gqqqsetppp sdiadidnle qadqerevkr
      361 rkyecticgr kfiqkshwre hmyihtgkpf kcstcdksfc ranqaarhvc lnqsidtytm
      421 vdkqtlelct feegsqmdnm lvqtnkpykc nlcdktfstp nevvkhscqn qnsdvfalde
      481 grsillgsgd sevtepdhpv lasikkeqet vlld
//

Conserved Domains (4) summary

sd00017
Location:365 → 385

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:363 → 385

zf-C2H2; Zinc finger, C2H2 type

pfam00651
Location:14 → 84

BTB; BTB/POZ domain

pfam13465
Location:377 → 399

zf-H2C2_2; Zinc-finger double domain