ZBTB6 (9q33.2), ZID, ZNF482

ZBTB6,https://www.ncbi.nlm.nih.gov/gene/10773

Official Symbol  ZBTB6

Official Full Name zinc finger and BTB domain containing 6provided by HGNC

Also known as ZID; ZNF482

Expression Ubiquitous expression in lymph node (RPKM 5.7), thyroid (RPKM 5.5) and 25 other tissues See more Orthologs  mouse all

1. NM_006626.6 → NP_006617.1  zinc finger and BTB domain-containing protein 6
   See identical proteins and their annotated locations for NP_006617.1
   

   Conserved Domains (5) summary

   sd00017
   Location:328 → 348

   ZF_C2H2; C2H2 Zn finger [structural motif]

   pfam00096
   Location:326 → 348

   zf-C2H2; Zinc finger, C2H2 type

   pfam00651
   Location:23 → 127

   BTB; BTB/POZ domain

   pfam13465
   Location:340 → 364

   zf-H2C2_2; Zinc-finger double domain

   pfam15909
   Location:331 → 401

   zf-C2H2_8; C2H2-type zinc ribbon

Related articles in PubMed

1. The POZ domain: a conserved protein-protein interaction motif. Bardwell VJ, et al. Genes Dev, 1994 Jul 15. PMID 795884  Abstract
   We describe a novel zinc finger protein, ZID (zinc finger protein with interaction domain). At its amino terminus ZID contains a 120-amino-acid conserved motif present in a large family of proteins that includes both the otherwise unrelated zinc finger proteins, such as Ttk, GAGA, and ZF5, and a group of poxvirus proteins: We therefore refer to this domain as the POZ (poxvirus and zinc finger) domain. The POZ domains of ZID, Ttk, and GAGA act to inhibit the interaction of their associated finger regions with DNA. This inhibitory effect is not dependent on interactions with other proteins and does not appear dependent on specific interactions between the POZ domain and the finger region. The POZ domain acts as a specific protein-protein interaction domain: The POZ domains of ZID and Ttk can interact with themselves but not with each other, POZ domains from ZF5, or the viral protein SalF17R. However, the POZ domain of GAGA can interact efficiently with the POZ domain of Ttk. In transfection experiments, the ZID POZ domain inhibits DNA binding in NIH-3T3 cells and appears to localize the protein to discrete regions of the nucleus. We discuss the implications of multimerization for the function of POZ domain proteins.
2. NAC1, a POZ/BTB protein that functions as a corepressor. Korutla L, et al. Neurochem Int, 2009 Mar-Apr. PMID 19121354We now demonstrate that NAC1 acts as a corepressor for other POZ/BTB proteins. NAC1 is a POZ/BTB motif containing transcriptional repressor protein. In a mammalian two hybrid assay in neuronal (N2A) cells and non-neuronal (HEK 293T) cells, VP16 activation domain tagged NAC1 resulted in significant reversal of transcriptional inhibition with the Gal4-ZID, Gal4-BCL6, Gal4-ZF5, and kelch proteins Gal4-MAYVEN (KLHL2)   and Gal4-NRP/B fusion proteins. We also observed similar results with another corepressor, BCoR Gal4 fusion protein. NAC1 potentiated ZF5 mediated repression in Gal4-DBD fusion transient assays. GST pulldown assays further confirmed protein-protein interactions between these proteins and NAC1. Both the NAC1 isoforms demonstrated selective interaction through the POZ/BTB domain but not with the non-POZ/BTB region. Endogenous NAC1 and BCL6 physically associated in CNS regions. Strikingly, NAC1 did not interact with the pro-myelocytic leukemia zinc finger protein (PLZF/ZBTB16) ), another POZ/BTB protein that is not found in the adult brain. Therefore, we conclude that NAC1 functions as a corepressor for POZ/BTB proteins expressed in the mature CNS.
3. Functional proteomics mapping of a human signaling pathway. Colland F, et al. Genome Res, 2004 Jul. PMID 15231748, Free PMC Article
4. An atlas of combinatorial transcriptional regulation in mouse and man. Ravasi T, et al. Cell, 2010 Mar 5. PMID 20211142, Free PMC Article
5. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article

See all (9) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene