Midkine Gene
- Full Report
- Gene location Chr. 11p11.2.
MDK midkine [ Homo sapiens (human) ]
Gene ID: 4192, updated on 7-Jan-2018- Official Symbol
- MDKprovided by HGNC
- Official Full Name
- midkineprovided by HGNC
- Primary source
- HGNC:HGNC:6972
- See related
- Ensembl:ENSG00000110492 MIM:162096; Vega:OTTHUMG00000150315
- Gene type
- protein coding
- RefSeq status
- REVIEWED
- Organism
- Homo sapiens
- Lineage
- Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
- Also known as
- MK; ARAP; NEGF2
- Summary
- This gene encodes a member of a small family of secreted growth factors that binds heparin and responds to retinoic acid. The encoded protein promotes cell growth, migration, and angiogenesis, in particular during tumorigenesis. This gene has been targeted as a therapeutic for a variety of different disorders. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]
- Expression
- Broad expression in ovary (RPKM 88.5), endometrium (RPKM 55.5) and 14 other tissues See more
Related articles in PubMed
- Diagnostic accuracy of ELISA for detecting serum Midkine in cancer patients. Jing X, et al. PLoS One, 2017. PMID 28686647, Free PMC Article
- Midkine is up-regulated in both cancerous and inflamed bowel, reflecting lymph node metastasis in colorectal cancer and clinical activity of ulcerative colitis. Krzystek-Korpacka M, et al. Cytokine, 2017 Jan. PMID 27692729
- Circulating midkine in children with Henoch-Schönlein purpura: Clinical implications. Su Z, et al. Int Immunopharmacol, 2016 Oct. PMID 27497193
- The role of midkine in the inflammatory process and its correlation with other inflammatory markers in renal transplant recipients. Uzun S, et al. Int J Artif Organs, 2016 Aug 19. PMID 27470002
- Serum midkine as a biomarker for malignancy, prognosis, and chemosensitivity in head and neck squamous cell carcinoma. Yamashita T, et al. Cancer Med, 2016 Mar. PMID 26798989, Free PMC Article
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