Midkine sytokiinin rakenne ja isoformien hsitoriaa

  Kuuntelin Midkine-proteiinista väitöskirjan tänään 19.1. 2018 ( Anna Nordin  väittelevä tutkija,  vastaväittäjä Oslon Yliopistosta professori Kristin Austlid Tasken. ISBN: 978-91-629--0374-9.

Etsin PubMed hakulaiteella midkine-proteiinin aminohapporakenteen ja geenisijainnin.

midkine isoform a precursor [Homo sapiens]

NCBI Reference Sequence: NP_001012333.1

Identical Proteins FASTA Graphics

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LOCUS       NP_001012333             143 aa            linear   PRI 03-OCT-2017
DEFINITION  midkine isoform a precursor [Homo sapiens].
ACCESSION   NP_001012333
VERSION     NP_001012333.1
DBSOURCE    REFSEQ: accession NM_001012333.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 143)
  AUTHORS   Muramatsu T.
  TITLE     Midkine, a heparin-binding cytokine with multiple roles in
            development, repair and diseases
  JOURNAL   Proc. Jpn. Acad., Ser. B, Phys. Biol. Sci. 86 (4), 410-425 (2010)
   PUBMED   20431264
  REMARK    Review article
REFERENCE   2  (residues 1 to 143)
  AUTHORS   Tao P, Xu D, Lin S, Ouyang GL, Chang Y, Chen Q, Yuan Y, Zhuo X, Luo
            Q, Li J, Li B, Ruan L, Li Q and Li Z.
  TITLE     Abnormal expression, highly efficient detection and novel
            truncations of midkine in human tumors, cancers and cell lines
  JOURNAL   Cancer Lett. 253 (1), 60-67 (2007)
   PUBMED   17379400
REFERENCE   3  (residues 1 to 143)
  AUTHORS   Iwasaki W, Nagata K, Hatanaka H, Inui T, Kimura T, Muramatsu T,
            Yoshida K, Tasumi M and Inagaki F.
  TITLE     Solution structure of midkine, a new heparin-binding growth factor
  JOURNAL   EMBO J. 16 (23), 6936-6946 (1997)
   PUBMED   9384573
REFERENCE   4  (residues 1 to 143)
  AUTHORS   Novotny WF, Maffi T, Mehta RL and Milner PG.
  TITLE     Identification of novel heparin-releasable proteins, as well as the
            cytokines midkine and pleiotrophin, in human postheparin plasma
  JOURNAL   Arterioscler. Thromb. 13 (12), 1798-1805 (1993)
   PUBMED   8241100
REFERENCE   5  (residues 1 to 143)
  AUTHORS   Kaname T, Kuwano A, Murano I, Uehara K, Muramatsu T and Kajii T.
  TITLE     Midkine gene (MDK), a gene for prenatal differentiation and
            neuroregulation, maps to band 11p11.2 by fluorescence in situ
            hybridization
  JOURNAL   Genomics 17 (2), 514-515 (1993)
   PUBMED   8406506
REFERENCE   6  (residues 1 to 143)
  AUTHORS   Fairhurst JL, Kretschmer PJ, Kovacs E, Bohlen P and Kovesdi I.
  TITLE     Structure of the gene coding for the human retinoic acid-inducible
            factor, MK
  JOURNAL   DNA Cell Biol. 12 (2), 139-147 (1993)
   PUBMED   8471163
REFERENCE   7  (residues 1 to 143)
  AUTHORS   Uehara K, Matsubara S, Kadomatsu K, Tsutsui J and Muramatsu T.
  TITLE     Genomic structure of human midkine (MK), a retinoic acid-responsive
            growth/differentiation factor
  JOURNAL   J. Biochem. 111 (5), 563-567 (1992)
   PUBMED   1639750
REFERENCE   8  (residues 1 to 143)
  AUTHORS   Shoyab M, McDonald VL, Dick K, Modrell B, Malik N and Plowman GD.
  TITLE     Amphiregulin-associated protein: complete amino acid sequence of a
            protein produced by the
            12-0-tetradecanoylphorbol-13-acetate-treated human breast
            adenocarcinoma cell line MCF-7
  JOURNAL   Biochem. Biophys. Res. Commun. 179 (1), 572-578 (1991)
   PUBMED   1883381
REFERENCE   9  (residues 1 to 143)
  AUTHORS   Tsutsui J, Uehara K, Kadomatsu K, Matsubara S and Muramatsu T.
  TITLE     A new family of heparin-binding factors: strong conservation of
            midkine (MK) sequences between the human and the mouse
  JOURNAL   Biochem. Biophys. Res. Commun. 176 (2), 792-797 (1991)
   PUBMED   2025291
REFERENCE   10 (residues 1 to 143)
  AUTHORS   Kretschmer PJ, Fairhurst JL, Decker MM, Chan CP, Gluzman Y, Bohlen
            P and Kovesdi I.
  TITLE     Cloning, characterization and developmental regulation of two
            members of a novel human gene family of neurite outgrowth-promoting
            proteins
  JOURNAL   Growth Factors 5 (2), 99-114 (1991)
   PUBMED   1768439
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI915189.1, BM016739.1,
            BC011704.2 and AI494596.1.
            
            Summary: This gene encodes a member of a small family of secreted
            growth factors that binds heparin and responds to retinoic acid.
            The encoded protein promotes cell growth, migration, and
            angiogenesis, in particular during tumorigenesis. This gene has
            been targeted as a therapeutic for a variety of different
            disorders. Alternatively spliced transcript variants encoding
            multiple isoforms have been observed. [provided by RefSeq, Jul
            2012].
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same
            isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CN266447.1, BM016739.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..143
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p11.2"
     Protein         1..143
                     /product="midkine isoform a precursor"
                     /note="amphiregulin-associated protein; midgestation and
                     kidney protein; neurite outgrowth-promoting factor 2;
                     retinoic acid inducible factor; neurite growth-promoting
                     factor 2"
                     /calculated_mol_wt=13421
     sig_peptide     1..20
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="{ECO:0000269|PubMed:15340161,
                     ECO:0000269|PubMed:1883381, ECO:0000269|PubMed:8241100};
                     propagated from UniProtKB/Swiss-Prot (P21741.1)"
                     /calculated_mol_wt=2183
     mat_peptide     21..143
                     /product="Midkine"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P21741.1)"
                     /calculated_mol_wt=13421
     Region          37..116
                     /region_name="PTN"
                     /note="Pleiotrophin / midkine family; smart00193"
                     /db_xref="CDD:128490"
     CDS             1..143
                     /gene="MDK"
                     /gene_synonym="ARAP; MK; NEGF2"
                     /coded_by="NM_001012333.2:177..608"
                     /note="isoform a precursor is encoded by transcript
                     variant 2"
                     /db_xref="CCDS:CCDS7919.1"
                     /db_xref="GeneID:4192"
                     /db_xref="HGNC:HGNC:6972"
                     /db_xref="MIM:162096"
ORIGIN      
        1 mqhrgflllt llallaltsa vakkkdkvkk ggpgsecaew awgpctpssk dcgvgfregt
       61 cgaqtqrirc rvpcnwkkef gadckykfen wgacdggtgt kvrqgtlkka rynaqcqeti
      121 rvtkpctpkt kakakakkgk gkd
//