Terminologia: Semaforiini, Semaforiner
Semaphorins
2003, 2011 :
”Semaphorins constitute one of the largest families of repulsive
and attractive growth cone guidance proteins. They affect the growth
cone's actin cytoskeleton through interactions with receptor
complexes composed of ligand-binding, signal-transducing, and
modulatory subunits. Our understanding of the intracellular signal
transduction machinery linking semaphorins to actin dynamics is
limited; however, recent advances provide a more comprehensive view
of the molecular basis of neuronal semaphorin signaling”.
- ” Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins.”
- 2010 ” Semaphorins are a large family, including both secreted and membrane associated proteins, many of which have been implicated as inhibitors or chemorepellents in axon pathfinding, fasciculation and branching, and target selection. All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Additional sequence motifs C-terminal to the semaphorin domain allow classification into distinct subfamilies. Results demonstrate that transmembrane semaphorins, like the secreted ones, can act as repulsive axon guidance cues. ”
(1) SEMA 3A (7q21.11) Semaphorin 3A
Muita nimiä: HH16,
SemD, COLL1, SEMA1, SEMAD, SEMAL, coll-1, Hsema-1, SEMAIII,
Hsema-III. Proteiini on vitaali normaalin neuronaalisen rakennemallin
kehkeytymiselle. Proteiinin liiallista ilmenemää esiintyy
skitsofreniassa ja eri tuumorisolulinjoissa. Proteiinin poikkeava
vapautuminen liittyy Alzheimerin taudin etenemiseen.
- Also known as HH16; SemD; COLL1; SEMA1; SEMAD; SEMAL; coll-1; Hsema-I; SEMAIII; Hsema-III
- Summary. This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease. [provided by RefSeq, Jul 2008]
- Expression: Broad expression in placenta (RPKM 2.5), gall bladder (RPKM 2.0) and 19 other tissues See more Orthologs mouse all
(2) SEMA4D (9q22.2) Semaphorin 4D
Muita nimiä: CD100, COLL4, SEMAJ, coll-4, C9orf154, M-sema-G.https://www.ncbi.nlm.nih.gov/gene/10507
CD100; COLL4; SEMAJ; coll-4; C9orf164; M-sema-G
- Expression Broad expression in lymph node (RPKM 12.0), appendix (RPKM 8.6) and 22 other tissues See more
- Orthologs mouse all
-
VEGF and SEMA4D have synergistic effects on the promotion of angiogenesis in epithelial ovarian cancer. Chen Y, et al. Cell Mol Biol Lett, 2018. PMID 29308068, Free PMC Article
-
New aspects of the Seam4D-dependent control of lymphocyte activation. Kuklina EM, et al. Dokl Biol Sci, 2017 Mar. PMID 28508207
-
Genome-wide analysis identifies an african-specific variant in SEMA4D associated with body mass index. Chen G, et al. Obesity (Silver Spring), 2017 Apr. PMID 28296344, Free PMC Article
-
Characterization of the Effects of Semaphorin 4D Signaling on Angiogenesis. Zhou H, et al. Methods Mol Biol, 2017. PMID 27787869
-
Isolating
Fc-Tagged SEMA4D Recombinant Protein from 293FT Cells. Soong J,
et al.
GeneRIFs: Gene References Into FunctionsWhat's
a GeneRIF?
(3) SEMA3F (3p21.31) Semaphorin 3F
Muita nimiä
SEMA4, SEMAK, SEMA-IV . Geeni ilmenee
endokriinisissä soluissa ja vaikuttaa autokriinisesti apoptoosia,
estää soluproliferaatiota ja solun elossapysymistä toimien
antitumorigeenisenä agenssina.
https://www.ncbi.nlm.nih.gov/gene/6405- Also known as SEMA4; SEMAK; SEMA-IV
- Summary: This gene encodes a member of the semaphorin III family of secreted signaling proteins that are involved in axon guidance during neuronal development. The encoded protein contains an N-terminal Sema domain, an immunoglobulin loop and a C-terminal basic domain. This gene is expressed by the endothelial cells where it was found to act in an autocrine fashion to induce apoptosis, inhibit cell proliferation and survival, and function as an anti-tumorigenic agent. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
- Expression: Broad expression in skin (RPKM 21.7), esophagus (RPKM 16.4) and 19 other tissues See more
GeneRIFs: Gene References Into FunctionsWhat's
a GeneRIF?
(4) SEMA7A (15q24.1) Semaphorin 7A
Muita nimiä: JMH
(John Milton Hagen blood group), CD108, SEMAL, CDw108, SEMAK1, H-Sema-L, H-SEMA-K1. GPI-ankkuroitunut kalvoglykoproteiini.
Esiintyy aktivoiduissa lymfosyyteissä ja
erytsosyyteissä ja osallistunee immunomodulaatioon ja
neuronaalisiin prosesseihin. Proteiini kantaa JMH-
veriryhmäantigeenia. Mutaatiot liittyvät alnetuneeseen luuston
mineraalitiheyteen.
- Also known as JMH; CD108; SEMAL; CDw108; SEMAK1; H-Sema-L; H-SEMA-K1
- Summary. This gene encodes a member of the semaphorin family of proteins. The encoded preproprotein is proteolytically processed to generate the mature glycosylphosphatidylinositol (GPI)-anchored membrane glycoprotein. The encoded protein is found on activated lymphocytes and erythrocytes and may be involved in immunomodulatory and neuronal processes. The encoded protein carries the John Milton Hagen (JMH) blood group antigens. Mutations in this gene may be associated with reduced bone mineral density (BMD). Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
- Expression. Broad expression in testis (RPKM 25.1), spleen (RPKM 22.9) and 14 other tissues See more
-
Validation of semaphorin 7A and ala-β-his-dipeptidase as biomarkers associated with the conversion from clinically isolated syndrome to multiple sclerosis. Cantó E, et al. J Neuroinflammation, 2014 Nov 13. PMID 25406498, Free PMC Article
-
Semaphorin 7A is expressed on airway eosinophils and upregulated by IL-5 family cytokines. Esnault S, et al. Clin Immunol, 2014 Jan. PMID 24333536, Free PMC Article
-
Semaphorin 7A protein variants differentially regulate T-cell activity. Gras C, et al. Transfusion, 2013 Feb. PMID 22845496
-
A new SEMA7A variant found in Native Americans with alloantibody. Richard M, et al. Vox Sang, 2011 Apr. PMID 20854351
-
Rapid
detection of JMH antibodies with recombinant Sema7A (CD108) protein
and the particle gel immunoassay. Seltsam A, et al.
Transfusion, 2008 Jun. PMID 18422858
See citations in PubMed for homologs of this gene provided by HomoloGene
GeneRIFs: Gene References Into FunctionsWhat's
a GeneRIF?
(5) SEMA3C (7q21.11) Semaphorin 3C
Muita nimiä:SemE, SEMAE. Luokka III semaforiini. Geenimutaatio assosioituu Hirschprungin tautiin.https://www.ncbi.nlm.nih.gov/gene/10512
- Also known as SemE; SEMAE
- Summary. This gene encodes a secreted glycoprotein that belongs to the semaphorin class 3 family of neuronal guidance cues. The encoded protein contains an N-terminal sema domain, integrin and immunoglobulin-like domains, and a C-terminal basic domain. Homodimerization and proteolytic cleavage of the C-terminal propeptide are necessary for the function of the encoded protein. It binds a neuropilin co-receptor before forming a heterotrimeric complex with an associated plexin. An increase in the expression of this gene correlates with an increase in cancer cell invasion and adhesion. Naturally occurring mutations in this gene are associated with Hirschsprung disease. [provided by RefSeq, May 2017]
- Expression. Broad expression in prostate (RPKM 41.1), urinary bladder (RPKM 40.3) and 20 other tissues See more
-
Class 3 semaphorins are transcriptionally regulated by 1,25(OH)2D3 in osteoblasts. Ryynänen J, et al. J Steroid Biochem Mol Biol, 2017 Oct. PMID 28189595
-
A Sema3C Mutant Resistant to Cleavage by Furin (FR-Sema3C) Inhibits Choroidal Neovascularization. Toledano S, et al. PLoS One, 2016. PMID 28036336, Free PMC Article
-
Class 3 semaphorins in cardiovascular development. Valdembri D, et al. Cell Adh Migr, 2016 Nov. PMID 27439112, Free PMC Article Secreted class 3 semaphorins (Sema3), which signal through holoreceptor complexes that are formed by different subunits, such as neuropilins (Nrps), proteoglycans, and plexins, were initially characterized as fundamental regulators of axon guidance during embryogenesis. Subsequently, Sema3A, Sema3C, Sema3D, and Sema3E were discovered to play crucial roles in cardiovascular development, mainly acting through Nrp1 and Plexin D1, which funnels the signal of multiple Sema3 in vascular endothelial cells. Mechanistically, Sema3 proteins control cardiovascular patterning through the enzymatic GTPase-activating-protein activity of the cytodomain of Plexin D1, which negatively regulates the function of Rap1, a small GTPase that is well-known for its ability to drive vascular morphogenesis and to elicit the conformational activation of integrin adhesion receptors.
-
Class 3 semaphorins induce F-actin reorganization in human dendritic cells: Role in cell migration. Curreli S, et al. J Leukoc Biol, 2016 Dec. PMID 27406993, Free PMC Article
-
Expression
of Semaphorin 3C in Breast Cancer and its Impact on Adhesion and
Invasion of Breast Cancer Cells. Malik MF, et al.
Anticancer Res, 2016 Mar. PMID 26977026
See citations in PubMed for homologs of this gene provided by HomoloGene
GeneRIFs: Gene References Into FunctionsWhat's
a GeneRIF?
(6) SEMA3B (3p21.31) Semaphorin 3B
Muita nimiä: SemA, SEMA5, SEMAA, SemaV, LUCA-1. Aksonin liikakasvun estäjä. Tuumorisuppressori.https://www.ncbi.nlm.nih.gov/gene/7869
- Also known as SemA; SEMA5; SEMAA; semaV; LUCA-1
- Summary. The protein encoded by this gene belongs to the class-3 semaphorin/collapsin family, whose members function in growth cone guidance during neuronal development. This family member inhibits axonal extension and has been shown to act as a tumor suppressor by inducing apoptosis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]
- Expression. Broad expression in placenta (RPKM 31.6), small intestine (RPKM 29.6) and 20 other tissues See more
(7) SEMA3E (7q21.11) Semaphorin 3E
Muita nimiä SEMAH, coll-5, M-SEMAH, M-SemaK. Aksonin kasvussa toimiva ohjaava ligandi multimeeristen kompleksin avulla. Miltei joka kompleksissa on plexiiniproteiineja.https://www.ncbi.nlm.nih.gov/gene/9723
- Also known as SEMAH; coll-5; M-SEMAH; M-SemaK
- Summary Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]
- Expression. Biased expression in brain (RPKM 3.1), gall bladder (RPKM 2.2) and 13 other tissues See more
-
Overexpression of Semaphorin-3E enhances pancreatic cancer cell growth and associates with poor patient survival. Yong LK, et al. Oncotarget, 2016 Dec 27. PMID 27911862, Free PMC Article
-
Enhanced expression of semaphorin 3E is involved in the gastric cancer development. Maejima R, et al. Int J Oncol, 2016 Sep. PMID 27572291, Free PMC Article
-
Epigenetically downregulated Semaphorin 3E contributes to gastric cancer. Chen H, et al. Oncotarget, 2015 Aug 21. PMID 26036259, Free PMC Article
-
Neuronal chemorepellent Semaphorin 3E inhibits human airway smooth muscle cell proliferation and migration. Movassagh H, et al. J Allergy Clin Immunol, 2014 Feb. PMID 23932461
-
A
role for class 3 semaphorins in prostate cancer. Blanc V, et
al. Prostate, 2011 May. PMID 20949546 OBS!
See citations in PubMed for homologs of this gene provided by HomoloGene
GeneRIFs: Gene References Into FunctionsWhat's
a GeneRIF?
(8) SEMA5A (5p15.31), Semaphorin 5A
Muita nimiä semF, SEMAF. Geeni assosioituu hippokampin kokoon ja kognitiivisen kapasiteetiin erääseen laatuun. Autismialttiusgeeni. TACE(ADAM17) osallistuneen semaforiini 5A-eritykseen. Semaforiini 5A vaikuttaa MMP9 eritystä mahasyövässä.
Also known as
semF; SEMAF
- Summary. This gene belongs to the semaphorin gene family that encodes membrane proteins containing a semaphorin domain and several thrombospondin type-1 repeats. Members of this family are involved in axonal guidance during neural development. This gene has been implicated as an autism susceptibility gene.[provided by RefSeq, Jan 2010]
- Expression. Broad expression in lung (RPKM 6.9), kidney (RPKM 6.5) and 24 other tissues See more , Orthologs mouse all
GeneRIFs: Gene
References Into FunctionsWhat's
a GeneRIF?
(9) SEMA4A (1q22) Semaphorin 4A
Muita nimiä RP35 (retinitis pigmentosa tyyppi 35), CORD10 (tappi-sauvadystrofia 10); Semaforiini 4A aktivoi T-soluvälitteistä immuniteettia (ILT4 on T-soluissa SEMA4A reseptori). Semaforiini 4A vaimentaaVEGF- välitteistä endoteelisolumigraatiota ja proliferaatiota koeputkessa ja angiogeneesiä in vivo.
https://www.ncbi.nlm.nih.gov/gene/64218
- Also known as RP35; SEMB; SEMAB; CORD10
- Summary This gene encodes a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in numerous functions, including axon guidance, morphogenesis, carcinogenesis, and immunomodulation. The encoded protein is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain and a sema domain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. It is an activator of T-cell-mediated immunity and suppresses vascular endothelial growth factor (VEGF)-mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo. Mutations in this gene are associated with retinal degenerative diseases including retinitis pigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010]
- Expression Broad expression in skin (RPKM 12.9), lymph node (RPKM 12.8) and 20 other tissues See more
-
On variants and disease-causing mutations: Case studies of a SEMA4A variant identified in inherited blindness. Bryant L, et al. Ophthalmic Genet, 2018 Jan-Feb. PMID 28805479, Free PMC Article
-
Doxorubicin-induced epithelial-mesenchymal transition through SEMA 4A in hepatocellular carcinoma. Pan JX, et al. Biochem Biophys Res Commun, 2016 Oct 28. PMID 27697528
-
Expression of Semaphorin 4A and its potential role in rheumatoid arthritis. Wang L, et al. Arthritis Res Ther, 2015 Aug 25. PMID 26303122, Free PMC Article
-
Germline variants in the SEMA4A gene predispose to familial colorectal cancer type X. Schulz E, et al. Nat Commun, 2014 Oct 13. PMID 25307848, Free PMC Article
-
Hypoxia-regulated
components of the U4/U6.U5 tri-small nuclear riboprotein complex:
possible role in autosomal dominant retinitis pigmentosa.
Schmidt-Kastner R, et al. Mol Vis, 2008 Jan 25. PMID
18334927, Free
PMC Article
See citations in PubMed for homologs of this gene provided by HomoloGene
GeneRIFs: Gene References Into FunctionsWhat's
a GeneRIF?
(10) SEMA4C (2q11.2) , Semaphorin 4C
Muita nimiä
SEMAF, SEMAI, SEMACL1, M-SEMA-F. Edistää imutiemetastaaseja
tuumorien e imusoluissa. MikroRNA:lla kohdennetavissa oleva.
SEMA4C on EMT:n positiivinen regulaattori.
Https://www.ncbi.nlm.nih.gov/gene/54910
- Also known as SEMAF; SEMAI; SEMACL1; M-SEMA-F Expression Ubiquitous expression in placenta (RPKM 20.2), endometrium (RPKM 13.1) and 24 other tissues See more Orthologs mouse all
-
Tumor-associated Lymphatic Endothelial Cells Promote Lymphatic Metastasis By Highly Expressing and Secreting SEMA4C. Wei JC, et al. Clin Cancer Res, 2017 Jan 1. PMID 27401250
-
[Expression and clinical significance of Sema4C in esophageal cancer, gastric cancer and rectal cancer]. Ye SM, et al. Zhonghua Yi Xue Za Zhi, 2012 Jul 24. PMID 22944267
-
Role of Sema4C in TGF-β1-induced mitogen-activated protein kinase activation and epithelial-mesenchymal transition in renal tubular epithelial cells. Zeng R, et al. Nephrol Dial Transplant, 2011 Apr. PMID 20959347, Free PMC Article
-
miR-25-3p reverses epithelial-mesenchymal transition via targeting Sema4C in cisplatin-resistance cervical cancer cells. Song J, et al. Cancer Sci, 2017 Jan. PMID 27743413, Free PMC Article
-
Erbin
interacts with Sema4C and inhibits Sema4C-induced
epithelial-mesenchymal transition in HK2 cells. Zhou QD, et
al. J Huazhong Univ Sci Technolog Med Sci, 2013 Oct. PMID
24142719
(11) SEMA4F (2p13.1) , Semaphorin 4F
Muita nimiä S4F, SEMAM, SEMAW, M-SEMA, PRO2353, mSema-M. Luokan IV semaforiini. Osallistunee prostatasyövän neurogeneesiin, neurofibroomien muodostumiseen, rintasyövän tumorigeneesiin.https://www.ncbi.nlm.nih.gov/gene/?term=SEMA4F
- Also known as S4F; SEMAM; SEMAW; M-SEMA; PRO2353; m-Sema-M
- Summary. This gene encodes a transmembrane class IV semaphorin family protein, which plays a role in neural development. This gene may be involved in neurogenesis in prostate cancer, the development of neurofibromas, and breast cancer tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
- Expression. Broad expression in brain (RPKM 2.1), testis (RPKM 1.1) and 22 other tissues See more
- Orthologs mouse all
-
Proteomic approaches to the analysis of atopic dermatitis and new insights from interactomics. Park YD, et al. Proteomics Clin Appl, 2008 Mar. PMID 21136834
-
Cancer-related axonogenesis and neurogenesis in prostate cancer. Ayala GE, et al. Clin Cancer Res, 2008 Dec 1. PMID 19047084
-
Comprehensive gene and microRNA expression profiling reveals the crucial role of hsa-let-7i and its target genes in colorectal cancer metastasis. Zhang P, et al. Mol Biol Rep, 2012 Feb. PMID 21625861
-
NF1 loss disrupts Schwann cell-axonal interactions: a novel role for semaphorin 4F. Parrinello S, et al. Genes Dev, 2008 Dec 1. PMID 19056885, Free PMC Article
-
Fine
mapping of the chromosome 2p12-16 dyslexia susceptibility locus:
quantitative association analysis and positional candidate genes
SEMA4F and OTX1. Francks C, et al. Psychiatr Genet,
2002 Mar. PMID 11901358
See citations in PubMed for homologs of this gene provided by HomoloGene
GeneRIFs: Gene References Into FunctionsWhat's
a GeneRIF?(12) (12
(12) SEMA6A (5q23.1) Semaphorin 6A
Muita nimiä: HT018, SEMA1, SEMAQ,VI A, SEMA6A1. Talamokortikaalisten ratojen asianmukainen muodostuminen. Angiogeneesin inhibiittori. Prognostinen biomarkkeri glioman hoidossa.https://www.ncbi.nlm.nih.gov/gene/57556
- Also known as VIA; SEMA; HT018; SEMAQ; SEMA6A1
- Summary. The transmembrane semaphorin SEMA6A is expressed in developing neural tissue and is required for proper development of the thalamocortical projection (Leighton et al., 2001 [PubMed 11242070]).[supplied by OMIM, Feb 2011]
- Expression Broad expression in adrenal (RPKM 13.5), placenta (RPKM 11.0) and 24 other tissues See more
- Orthologs mouse all
-
Characterization of Semaphorin 6A-Mediated Effects on Angiogenesis Through Regulation of VEGF Signaling. Ohnuki H, et al. Methods Mol Biol, 2017. PMID 27787863, Free PMC Article
-
SEMA6A is a prognostic biomarker in glioblastoma. Zhao J, et al. Tumour Biol, 2015 Nov. PMID 26014517
-
From plasma membrane to cytoskeleton: a novel function for semaphorin 6A. Prislei S, et al. Mol Cancer Ther, 2008 Jan. PMID 18187809
-
The class 6 semaphorin SEMA6A is induced by interferon-gamma and defines an activation status of langerhans cells observed in pathological situations. Gautier G, et al. Am J Pathol, 2006 Feb. PMID 16436660, Free PMC Article
-
Comparative
integromics on non-canonical WNT or planar cell polarity signaling
molecules: transcriptional mechanism of PTK7 in colorectal cancer
and that of SEMA6A in undifferentiated ES cells. Katoh M, et
al. Int J Mol Med, 2007 Sep. PMID 17671748
See citations in PubMed for homologs of this gene provided by HomoloGene
GeneRIFs: Gene References Into FunctionsWhat's
a GeneRIF?
(13) SEMA3D (7q21.11), Semaphorin 3D
Muita nimiä: Sema-Z2, coll-2
(collapsin family member). Tämä geenin koodaama proteiini sitoo
neuropiliiniä ja on tärkeä kardiovaskulaarfisessa kehityksessä,.
https://www.ncbi.nlm.nih.gov/gene/223117- Also known as coll-2; Sema-Z2
- Summary. This gene encodes a member of the semaphorin III family of secreted signaling proteins that are involved in axon guidance during neuronal develoent.pm The encoded protein contains an N-terminal Sema domain, an immunoglobulin like domain and a C-terminal basic domain. The protein encoded by this gene binds neuropilin and plays an important role in cardiovascular development. [provided by RefSeq, Aug 2016]
- Expression. Biased expression in spleen (RPKM 23.4), thyroid (RPKM 18.9) and 13 other tissues See more
-
Decreased expression of semaphorin 3D is associated with genesis and development in colorectal cancer. Wang Z, et al. World J Surg Oncol, 2017 Mar 20. PMID 28320475, Free PMC Article
-
Possible association of the semaphorin 3D gene (SEMA3D) with schizophrenia. Fujii T, et al. J Psychiatr Res, 2011 Jan. PMID 20684831
-
Semaphorin profiling of periodontal fibroblasts and osteoblasts. Lallier TE. J Dent Res, 2004 Sep. PMID 15329371 OBS!
-
Variable expressivity and genetic heterogeneity involving DPT and SEMA3D genes in autosomal dominant familial Meniere's disease. Martín-Sierra C, et al. Eur J Hum Genet, 2017 Feb. PMID 27876815, Free PMC Article
-
CTNNA3
and SEMA3D: Promising loci for asthma exacerbation identified
through multiple genome-wide association studies. McGeachie MJ,
et al. J Allergy Clin Immunol, 2015 Dec. PMID 26073756,
Free
PMC Article
See citations in PubMed for homologs of this gene provided by HomoloGene
GeneRIFs: Gene References Into FunctionsWhat's
a GeneRIF?
(14) SEMA6D (15q21.1) Semaphorin 6D
Muita nimiä: NC-000015-10https://www.ncbi.nlm.nih.gov/gene/80031
- Summary. Semaphorins are a large family, including both secreted and membrane associated proteins, many of which have been implicated as inhibitors or chemorepellents in axon pathfinding, fasciculation and branching, and target selection. All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Additional sequence motifs C-terminal to the semaphorin domain allow classification into distinct subfamilies. Results demonstrate that transmembrane semaphorins, like the secreted ones, can act as repulsive axon guidance cues. This gene encodes a class 6 vertebrate transmembrane semaphorin that demonstrates alternative splicing. Several transcript variants have been identified and expression of the distinct encoded isoforms is thought to be regulated in a tissue- and development-dependent manner. [provided by RefSeq, Nov 2010]
- Expression
- Broad expression in small intestine (RPKM 13.9), placenta (RPKM 10.4) and 19 other tissues See more
-
Expression of semaphorin 6D in gastric carcinoma and its significance. Zhao XY, et al. World J Gastroenterol, 2006 Dec 7. PMID 17143962, Free PMC Article
-
Knowing how to navigate: mechanisms of semaphorin signaling in the nervous system. He Z, et al. Sci STKE, 2002 Feb 12. PMID 11842242
-
Identification, characterization, and functional study of the two novel human members of the semaphorin gene family. Qu X, et al. J Biol Chem, 2002 Sep 20. PMID 12110693
-
Novel genetic variants modify the effect of smoking on carotid plaque burden in Hispanics. Della-Morte D, et al. J Neurol Sci, 2014 Sep 15. PMID 24954085, Free PMC Article
-
Plexin-A1
and its interaction with DAP12 in immune responses and bone
homeostasis. Takegahara N, et al. Nat Cell Biol, 2006
Jun. PMID 16715077
See citations in PubMed for homologs of this gene provided by HomoloGene
GeneRIFs: Gene References Into FunctionsWhat's
a GeneRIF?
(15) SEMA4B 15q25.1. Semaphorin 4B
Muita nimiä: SEMAC, SemC ( vain lyhyt teksti)- SemC; SEMAC
- Expression
- Ubiquitous expression in esophagus (RPKM 24.0), skin (RPKM 20.0) and 25 other tissues See more
-
SEMA4B inhibits growth of non-small cell lung cancer in vitro and in vivo. Jian H, et al. Cell Signal, 2015 Jun. PMID 25746385
-
SEMA4b inhibits MMP9 to prevent metastasis of non-small cell lung cancer. Jian H, et al. Tumour Biol, 2014 Nov. PMID 25095981
-
Hypoxia and hypoxia-inducible factor 1 repress SEMA4B expression to promote non-small cell lung cancer invasion. Jian H, et al. Tumour Biol, 2014 May. PMID 24474252
-
Sema domain of semaphorin 4B (SEMA4B), which is an interacting protein of LNM35, plays an important role in lung cancer invasion. However, the regulation mechanism of this protein is completely unknown. Here, we report that hypoxia and hypoxia mimic reagent could downregulate the expression of SEMA4B in human non-small cell lung cancer (NSCLC) lines. We provide evidences that SEMA4B is a direct target of hypoxia-inducible factor 1 (HIF-1). Silencing the expression of HIF-1α in cancer cells by RNA interference abolished hypoxia-repressed SEMA4B expression. Using luciferase reporter assay, we showed that HIF-1α recognized a hypoxia-responsive element (HRE) of SEMA4B gene, which is required for HIF-1-repressed SEMA4B expression. Moreover, ectopic expression of SEMA4B abolished invasion of hypoxia-induced NSCLC cells. Taken together, these data would shed novel insights on the mechanisms for invasion of hypoxia-induced NSCLC cells.
-
CLCP1 interacts with semaphorin 4B and regulates motility of lung cancer cells. Nagai H, et al. Oncogene, 2007 Jun 7. PMID 17213806
-
Murine
semaphorin D/collapsin is a member of a diverse gene family and
creates domains inhibitory for axonal extension. Püschel AW, et
al. Neuron, 1995 May. PMID 7748561
(16) SEMA4G , 10q24.31. Semaphorin 4G
Ei muita nimiä- https://www.ncbi.nlm.nih.gov/gene/57715
- Summary Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
- Expression
- Broad expression in duodenum (RPKM 18.5), small intestine (RPKM 15.9) and 20 other tissues See more
(17) SEMA6B , ( 19p13.3) Semaphorin 6B
Muita nimiä: SEM-SEMA-Y, SEMA VIB,SEMAN, SemaZ. PPAR säätää tämän geenin vahvasti alas. Tällä geenillä on assosiaatioita tuumorien differentioitumiseen ja metasaasiin.https://www.ncbi.nlm.nih.gov/gene/10501
- Also known as SEMAN; semaZ; SEMA-VIB; SEM-SEMA-Y
- Summary. This gene encodes a member of the semaphorin family, a group of proteins characterized by the presence of a conserved semaphorin (sema) domain. Whereas some semaphorins are transmembrane proteins, others are secreted. Semaphorins play a major role in axon guidance. The protein encoded by this gene may be involved in both peripheral and central nervous system development. [provided by RefSeq, Jul 2008]
- Expression Broad expression in brain (RPKM 18.7), spleen (RPKM 8.6) and 15 other tissues See more
- Orthologs mouse all
-
The role of axon guidance factor semaphorin 6B in the invasion and metastasis of gastric cancer. Ge C, et al. J Int Med Res, 2013 Apr. PMID 23781008
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Analysis of SEMA6B gene expression in breast cancer: identification of a new isoform. D'Apice L, et al. Biochim Biophys Acta, 2013 Oct. PMID 23665584
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The human semaphorin 6B gene is down regulated by PPARs. Collet P, et al. Genomics, 2004 Jun. PMID 15177567
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Human semaphorin 6B [(HSA)SEMA6B], a novel human class 6 semaphorin gene: alternative splicing and all-trans-retinoic acid-dependent downregulation in glioblastoma cell lines. Correa RG, et al. Genomics, 2001 May 1. PMID 11350127
-
Signal
peptide prediction based on analysis of experimentally verified
cleavage sites. Zhang Z, et al. Protein Sci, 2004 Oct.
PMID 15340161, Free
PMC Article
See citations in PubMed for homologs of this gene provided by HomoloGene
GeneRIFs: Gene References Into FunctionsWhat's
a GeneRIF?
Submit: New
GeneRIF Correction
(18) SEMA3G, (3p21.1), Semaphorin 3G
Muita nimiä: Sem2. Tämän geenin transkriptio aktivoituu PPAR-gammalla.https://www.ncbi.nlm.nih.gov/gene/56920
- Also known as sem2
- Summary. The transcription of this gene is activated by PPAR-gamma, and the resulting protein product plays a role in endothelial cell migration. Expression of this gene also inhibits tumor cell migration and invasion. [provided by RefSeq, Jul 2016]
- Expression
- Biased expression in fat (RPKM 51.5), placenta (RPKM 13.3) and 10 other tissues See more
- Orthologs
- mouse all
-
PPAR-γ promotes endothelial cell migration by inducing the expression of Sema3g. Liu W, et al. J Cell Biochem, 2015 Apr. PMID 25335934
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Effects of SEMA3G on migration and invasion of glioma cells. Zhou X, et al. Oncol Rep, 2012 Jul. PMID 22562223
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A novel podocyte gene, semaphorin 3G, protects glomerular podocyte from lipopolysaccharide-induced inflammation. Ishibashi R, et al. Sci Rep, 2016 May 16. PMID 27180624, Free PMC Article
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Semaphorin, neuropilin and VEGF expression in glial tumours: SEMA3G, a prognostic marker? Karayan-Tapon L, et al. Br J Cancer, 2008 Oct 7. PMID 18781179, Free PMC Article
-
Differential
endothelial transcriptomics identifies semaphorin 3G as a vascular
class 3 semaphorin. Kutschera S, et al. Arterioscler
Thromb Vasc Biol, 2011 Jan. PMID 20947821
See citations in PubMed for homologs of this gene provided by HomoloGene
GeneRIFs: Gene References Into FunctionsWhat's
a GeneRIF?
(19) SEMA5B, (3q21.1), Semaphorin 5B
Muita nimiä: SEMAG, SemGhttps://www.ncbi.nlm.nih.gov/gene/54437
- Also known as SemG; SEMAG
- Summary. This gene encodes a member of the semaphorin protein family which regulates axon growth during development of the nervous system. The encoded protein has a characteristic Sema domain near the N-terminus, through which semaphorins bind to plexin, and five thrombospondin type 1 repeats in the C-terminal region of the protein. The protein product may be cleaved and exist as a secreted molecule (PMID: 19463192). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
- Expression. Broad expression in brain (RPKM 2.8), heart (RPKM 1.3) and 16 other tissues See more
- Orthologs mouse all
-
Semaphorin 5B mediates synapse elimination in hippocampal neurons. O'Connor TP, et al. Neural Dev, 2009 May 23. PMID 19463192, Free PMC Article
-
Driver Gene and Novel Mutations in Asbestos-Exposed Lung Adenocarcinoma and Malignant Mesothelioma Detected by Exome Sequencing. Mäki-Nevala S, et al. Lung, 2016 Feb. PMID 26463840 Asbestos is a carcinogen linked to malignant mesothelioma (MM) and lung cancer. Some gene aberrations related to asbestos exposure are recognized, but many associated mutations remain obscure. We performed exome sequencing to determine the association of previously known mutations (driver gene mutations) with asbestos and to identify novel mutations related to asbestos exposure in lung adenocarcinoma (LAC) and MM.
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A novel class of murine semaphorins with homology to thrombospondin is differentially expressed during early embryogenesis. Adams RH, et al. Mech Dev, 1996 Jun. PMID 8817451
-
Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations. Wu C, et al. Nat Genet, 2011 Jun 5. PMID 21642993
-
Prediction
of the coding sequences of unidentified human genes. XVII. The
complete sequences of 100 new cDNA clones from brain which code for
large proteins in vitro. Nagase T, et al. DNA Res, 2000
Apr 28. PMID 10819331
See citations in PubMed for homologs of this gene provided by HomoloGene
GeneRIFs: Gene References Into FunctionsWhat's
a GeneRIF?
(20) SEMA6C, ( 1q21.3) , Semaphorin 6C
Muita nimiä:
SEMAY, m-SemaY, m-SemaY2 Semaforiinit edustavat tärkeitä
molekulaarisia signaaleita keskushermostovaurion jälkeisissä
soluvasteissa ja niillä voi olla tärkeä osuus neuraalisessa
regeneraatiossa.
- Also known as SEMAY; m-SemaY; m-SemaY2
- Summary: This gene encodes a member of the semaphorin family. Semaphorins represent important molecular signals controlling multiple aspects of the cellular response that follows CNS injury, and thus may play an important role in neural regeneration. [provided by RefSeq, May 2010]
- Expression. Broad expression in testis (RPKM 9.5), heart (RPKM 5.4) and 20 other tissues See more
- Orthologs mouse all
-
Emerging roles for semaphorins in neural regeneration. Pasterkamp RJ, et al. Brain Res Brain Res Rev, 2001 Mar. PMID 11245885
-
Identification, characterization, and functional study of the two novel human members of the semaphorin gene family. Qu X, et al. J Biol Chem, 2002 Sep 20. PMID 12110693
-
Polymorphisms in genes involved in neurodevelopment may be associated with altered brain morphology in schizophrenia: preliminary evidence. Gregório SP, et al. Psychiatry Res, 2009 Jan 30. PMID 19054571
-
Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis. Imabayashi H, et al. Exp Cell Res, 2003 Aug 1. PMID 12878157
-
Prediction
of the coding sequences of unidentified human genes. XX. The
complete sequences of 100 new cDNA clones from brain which code for
large proteins in vitro. Nagase T, et al. DNA Res, 2001
Apr 27. PMID 11347906
See citations in PubMed for homologs of this gene provided by HomoloGene
25.2. 2019 Muistiin lähdetietoa semaforiineista. Koska tämä on aika uusi asia minulle, otin monta esimerkkiä ja artikkelia. poistan myöhemmin osan ja jätän vain geenilinkin PubMed.
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