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måndag 25 februari 2019

20 semaforiinia . lähdeartikkeleita (PubMed)

Terminologia:  Semaforiini, Semaforiner 

Semaphorins

2003, 2011 : ”Semaphorins constitute one of the largest families of repulsive and attractive growth cone guidance proteins. They affect the growth cone's actin cytoskeleton through interactions with receptor complexes composed of ligand-binding, signal-transducing, and modulatory subunits. Our understanding of the intracellular signal transduction machinery linking semaphorins to actin dynamics is limited; however, recent advances provide a more comprehensive view of the molecular basis of neuronal semaphorin signaling”.

” Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins.”
2010 ” Semaphorins are a large family, including both secreted and membrane associated proteins, many of which have been implicated as inhibitors or chemorepellents in axon pathfinding, fasciculation and branching, and target selection. All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Additional sequence motifs C-terminal to the semaphorin domain allow classification into distinct subfamilies. Results demonstrate that transmembrane semaphorins, like the secreted ones, can act as repulsive axon guidance cues. ”

(1) SEMA 3A (7q21.11) Semaphorin 3A

Muita nimiä: HH16, SemD, COLL1, SEMA1, SEMAD, SEMAL, coll-1, Hsema-1, SEMAIII, Hsema-III. Proteiini on vitaali normaalin neuronaalisen rakennemallin kehkeytymiselle. Proteiinin liiallista ilmenemää esiintyy skitsofreniassa ja eri tuumorisolulinjoissa. Proteiinin poikkeava vapautuminen liittyy Alzheimerin taudin etenemiseen.

Also known as HH16; SemD; COLL1; SEMA1; SEMAD; SEMAL; coll-1; Hsema-I; SEMAIII; Hsema-III
Summary. This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease. [provided by RefSeq, Jul 2008]
Expression: Broad expression in placenta (RPKM 2.5), gall bladder (RPKM 2.0) and 19 other tissues See more Orthologs mouse all

(2) SEMA4D (9q22.2) Semaphorin 4D

Muita nimiä: CD100, COLL4, SEMAJ, coll-4, C9orf154, M-sema-G.
https://www.ncbi.nlm.nih.gov/gene/10507
CD100; COLL4; SEMAJ; coll-4; C9orf164; M-sema-G
Expression Broad expression in lymph node (RPKM 12.0), appendix (RPKM 8.6) and 22 other tissues See more
Orthologs mouse all

Related articles in PubMed
  1. New aspects of the Seam4D-dependent control of lymphocyte activation. Kuklina EM, et al. Dokl Biol Sci, 2017 Mar. PMID 28508207
  2. Characterization of the Effects of Semaphorin 4D Signaling on Angiogenesis. Zhou H, et al. Methods Mol Biol, 2017. PMID 27787869
  3. Isolating Fc-Tagged SEMA4D Recombinant Protein from 293FT Cells. Soong J, et al.
GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?
  1. We identified a novel genome-wide significant African-specific locus for BMI (SEMA4D, rs80068415). A novel variant in SEMA4D was significantly associated with body mass index. Carriers of the C allele were 4.6 BMI units heavier than carriers of the T allele.

(3) SEMA3F (3p21.31) Semaphorin 3F

Muita nimiä SEMA4, SEMAK, SEMA-IV . Geeni ilmenee endokriinisissä soluissa ja vaikuttaa autokriinisesti apoptoosia, estää soluproliferaatiota ja solun elossapysymistä toimien antitumorigeenisenä agenssina.
https://www.ncbi.nlm.nih.gov/gene/6405
Also known as SEMA4; SEMAK; SEMA-IV
Summary: This gene encodes a member of the semaphorin III family of secreted signaling proteins that are involved in axon guidance during neuronal development. The encoded protein contains an N-terminal Sema domain, an immunoglobulin loop and a C-terminal basic domain. This gene is expressed by the endothelial cells where it was found to act in an autocrine fashion to induce apoptosis, inhibit cell proliferation and survival, and function as an anti-tumorigenic agent. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
Expression: Broad expression in skin (RPKM 21.7), esophagus (RPKM 16.4) and 19 other tissues See more

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?
  1. SEMA3F functions as a suppressor of colorectal cancer metastasis by down-regulating the ASCL2-CXCR4 signaling axis.

(4) SEMA7A (15q24.1) Semaphorin 7A

Muita nimiä: JMH (John Milton Hagen blood group), CD108, SEMAL, CDw108, SEMAK1, H-Sema-L, H-SEMA-K1. GPI-ankkuroitunut kalvoglykoproteiini. Esiintyy aktivoiduissa lymfosyyteissä ja erytsosyyteissä ja osallistunee immunomodulaatioon ja neuronaalisiin prosesseihin. Proteiini kantaa JMH- veriryhmäantigeenia. Mutaatiot liittyvät alnetuneeseen luuston mineraalitiheyteen.

https://www.ncbi.nlm.nih.gov/gene/8482
Also known as JMH; CD108; SEMAL; CDw108; SEMAK1; H-Sema-L; H-SEMA-K1
Summary. This gene encodes a member of the semaphorin family of proteins. The encoded preproprotein is proteolytically processed to generate the mature glycosylphosphatidylinositol (GPI)-anchored membrane glycoprotein. The encoded protein is found on activated lymphocytes and erythrocytes and may be involved in immunomodulatory and neuronal processes. The encoded protein carries the John Milton Hagen (JMH) blood group antigens. Mutations in this gene may be associated with reduced bone mineral density (BMD). Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
Expression. Broad expression in testis (RPKM 25.1), spleen (RPKM 22.9) and 14 other tissues See more
Related articles in PubMed
  1. Semaphorin 7A protein variants differentially regulate T-cell activity. Gras C, et al. Transfusion, 2013 Feb. PMID 22845496
  2. A new SEMA7A variant found in Native Americans with alloantibody. Richard M, et al. Vox Sang, 2011 Apr. PMID 20854351
  3. Rapid detection of JMH antibodies with recombinant Sema7A (CD108) protein and the particle gel immunoassay. Seltsam A, et al. Transfusion, 2008 Jun. PMID 18422858
See all (47) citations in PubMed
See citations in PubMed for homologs of this gene provided by HomoloGene
GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?
  1. SEMA7A was expressed in the liver and was increased in the course of liver fibrosis, both in mice and in humans.

(5) SEMA3C (7q21.11) Semaphorin 3C

Muita nimiä:SemE, SEMAE. Luokka III semaforiini. Geenimutaatio assosioituu Hirschprungin tautiin.
https://www.ncbi.nlm.nih.gov/gene/10512
Also known as SemE; SEMAE
Summary. This gene encodes a secreted glycoprotein that belongs to the semaphorin class 3 family of neuronal guidance cues. The encoded protein contains an N-terminal sema domain, integrin and immunoglobulin-like domains, and a C-terminal basic domain. Homodimerization and proteolytic cleavage of the C-terminal propeptide are necessary for the function of the encoded protein. It binds a neuropilin co-receptor before forming a heterotrimeric complex with an associated plexin. An increase in the expression of this gene correlates with an increase in cancer cell invasion and adhesion. Naturally occurring mutations in this gene are associated with Hirschsprung disease. [provided by RefSeq, May 2017]
Expression. Broad expression in prostate (RPKM 41.1), urinary bladder (RPKM 40.3) and 20 other tissues See more
Related articles in PubMed
  1. Class 3 semaphorins are transcriptionally regulated by 1,25(OH)2D3 in osteoblasts. Ryynänen J, et al. J Steroid Biochem Mol Biol, 2017 Oct. PMID 28189595
  2. Class 3 semaphorins in cardiovascular development. Valdembri D, et al. Cell Adh Migr, 2016 Nov. PMID 27439112, Free PMC Article Secreted class 3 semaphorins (Sema3), which signal through holoreceptor complexes that are formed by different subunits, such as neuropilins (Nrps), proteoglycans, and plexins, were initially characterized as fundamental regulators of axon guidance during embryogenesis. Subsequently, Sema3A, Sema3C, Sema3D, and Sema3E were discovered to play crucial roles in cardiovascular development, mainly acting through Nrp1 and Plexin D1, which funnels the signal of multiple Sema3 in vascular endothelial cells. Mechanistically, Sema3 proteins control cardiovascular patterning through the enzymatic GTPase-activating-protein activity of the cytodomain of Plexin D1, which negatively regulates the function of Rap1, a small GTPase that is well-known for its ability to drive vascular morphogenesis and to elicit the conformational activation of integrin adhesion receptors.



  1. Expression of Semaphorin 3C in Breast Cancer and its Impact on Adhesion and Invasion of Breast Cancer Cells. Malik MF, et al. Anticancer Res, 2016 Mar. PMID 26977026
See all (46) citations in PubMed
See citations in PubMed for homologs of this gene provided by HomoloGene
GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?
  1. Glioma stem cells preferentially secrete Sema3C and coordinately express PlexinA2/D1 receptors to activate Rac1/nuclear factor (NF)-kB signaling.

(6) SEMA3B (3p21.31) Semaphorin 3B

Muita nimiä: SemA, SEMA5, SEMAA, SemaV, LUCA-1. Aksonin liikakasvun estäjä. Tuumorisuppressori.
https://www.ncbi.nlm.nih.gov/gene/7869
Also known as SemA; SEMA5; SEMAA; semaV; LUCA-1
Summary. The protein encoded by this gene belongs to the class-3 semaphorin/collapsin family, whose members function in growth cone guidance during neuronal development. This family member inhibits axonal extension and has been shown to act as a tumor suppressor by inducing apoptosis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Expression. Broad expression in placenta (RPKM 31.6), small intestine (RPKM 29.6) and 20 other tissues See more

(7) SEMA3E (7q21.11) Semaphorin 3E

Muita nimiä SEMAH, coll-5, M-SEMAH, M-SemaK. Aksonin kasvussa toimiva ohjaava ligandi multimeeristen kompleksin avulla. Miltei joka kompleksissa on plexiiniproteiineja.

 https://www.ncbi.nlm.nih.gov/gene/9723

Also known as SEMAH; coll-5; M-SEMAH; M-SemaK
Summary Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]
Expression. Biased expression in brain (RPKM 3.1), gall bladder (RPKM 2.2) and 13 other tissues See more
Related articles in PubMed
  1. A role for class 3 semaphorins in prostate cancer. Blanc V, et al. Prostate, 2011 May. PMID 20949546 OBS!
See all (44) citations in PubMed
See citations in PubMed for homologs of this gene provided by HomoloGene
GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?
  1. these results identify SEMA3E as an essential gene for GnRH neuron development, uncover a neurotrophic function for SEMA3E in the developing brain

(8) SEMA5A (5p15.31), Semaphorin 5A

Muita nimiä semF, SEMAF. Geeni assosioituu hippokampin kokoon ja kognitiivisen kapasiteetiin erääseen laatuun. Autismialttiusgeeni. TACE(ADAM17) osallistuneen semaforiini 5A-eritykseen. Semaforiini 5A vaikuttaa MMP9 eritystä mahasyövässä.
 Also known as semF; SEMAF
Summary. This gene belongs to the semaphorin gene family that encodes membrane proteins containing a semaphorin domain and several thrombospondin type-1 repeats. Members of this family are involved in axonal guidance during neural development. This gene has been implicated as an autism susceptibility gene.[provided by RefSeq, Jan 2010]
Expression. Broad expression in lung (RPKM 6.9), kidney (RPKM 6.5) and 24 other tissues See more , Orthologs mouse all
GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  1. Data show that Semaphorin 5A (Sema5A) and plexin-B3 inhibit glioma cell invasion through Rac1 inactivation.

(9) SEMA4A (1q22) Semaphorin 4A

Muita nimiä RP35 (retinitis pigmentosa tyyppi 35), CORD10 (tappi-sauvadystrofia 10); Semaforiini 4A aktivoi T-soluvälitteistä immuniteettia (ILT4 on T-soluissa SEMA4A reseptori). Semaforiini 4A vaimentaaVEGF- välitteistä endoteelisolumigraatiota ja proliferaatiota koeputkessa ja angiogeneesiä in vivo.

https://www.ncbi.nlm.nih.gov/gene/64218

Also known as RP35; SEMB; SEMAB; CORD10
Summary This gene encodes a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in numerous functions, including axon guidance, morphogenesis, carcinogenesis, and immunomodulation. The encoded protein is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain and a sema domain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. It is an activator of T-cell-mediated immunity and suppresses vascular endothelial growth factor (VEGF)-mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo. Mutations in this gene are associated with retinal degenerative diseases including retinitis pigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010]
Expression Broad expression in skin (RPKM 12.9), lymph node (RPKM 12.8) and 20 other tissues See more
Related articles in PubMed
  1. Doxorubicin-induced epithelial-mesenchymal transition through SEMA 4A in hepatocellular carcinoma. Pan JX, et al. Biochem Biophys Res Commun, 2016 Oct 28. PMID 27697528
  2. Expression of Semaphorin 4A and its potential role in rheumatoid arthritis. Wang L, et al. Arthritis Res Ther, 2015 Aug 25. PMID 26303122, Free PMC Article
  3. Hypoxia-regulated components of the U4/U6.U5 tri-small nuclear riboprotein complex: possible role in autosomal dominant retinitis pigmentosa. Schmidt-Kastner R, et al. Mol Vis, 2008 Jan 25. PMID 18334927, Free PMC Article
See all (34) citations in PubMed
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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  1. Germline variants in SEMA4A predispose to familial colorectal cancer type X.

(10) SEMA4C (2q11.2) , Semaphorin 4C

Muita nimiä SEMAF, SEMAI, SEMACL1, M-SEMA-F. Edistää imutiemetastaaseja tuumorien e imusoluissa. MikroRNA:lla kohdennetavissa oleva. SEMA4C on EMT:n positiivinen regulaattori.

 Https://www.ncbi.nlm.nih.gov/gene/54910

Also known as SEMAF; SEMAI; SEMACL1; M-SEMA-F Expression Ubiquitous expression in placenta (RPKM 20.2), endometrium (RPKM 13.1) and 24 other tissues See more Orthologs mouse all
Related articles in PubMed
  1. Erbin interacts with Sema4C and inhibits Sema4C-induced epithelial-mesenchymal transition in HK2 cells. Zhou QD, et al. J Huazhong Univ Sci Technolog Med Sci, 2013 Oct. PMID 24142719

(11) SEMA4F (2p13.1) , Semaphorin 4F

Muita nimiä S4F, SEMAM, SEMAW, M-SEMA, PRO2353, mSema-M. Luokan IV semaforiini. Osallistunee prostatasyövän neurogeneesiin, neurofibroomien muodostumiseen, rintasyövän tumorigeneesiin.
https://www.ncbi.nlm.nih.gov/gene/?term=SEMA4F
Also known as S4F; SEMAM; SEMAW; M-SEMA; PRO2353; m-Sema-M
Summary. This gene encodes a transmembrane class IV semaphorin family protein, which plays a role in neural development. This gene may be involved in neurogenesis in prostate cancer, the development of neurofibromas, and breast cancer tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Expression. Broad expression in brain (RPKM 2.1), testis (RPKM 1.1) and 22 other tissues See more
Orthologs mouse all
 Related articles in PubMed
  1. Proteomic approaches to the analysis of atopic dermatitis and new insights from interactomics. Park YD, et al. Proteomics Clin Appl, 2008 Mar. PMID 21136834
  2. Cancer-related axonogenesis and neurogenesis in prostate cancer. Ayala GE, et al. Clin Cancer Res, 2008 Dec 1. PMID 19047084
  3. Fine mapping of the chromosome 2p12-16 dyslexia susceptibility locus: quantitative association analysis and positional candidate genes SEMA4F and OTX1. Francks C, et al. Psychiatr Genet, 2002 Mar. PMID 11901358
See all (26) citations in PubMed
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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?(12) (12
  1. Fine mapping of the chromosome 2p12-16 dyslexia susceptibility candidate gene

 (12) SEMA6A (5q23.1) Semaphorin 6A

Muita nimiä: HT018, SEMA1, SEMAQ,VI A, SEMA6A1. Talamokortikaalisten ratojen asianmukainen muodostuminen. Angiogeneesin inhibiittori. Prognostinen biomarkkeri glioman hoidossa.
https://www.ncbi.nlm.nih.gov/gene/57556
Also known as VIA; SEMA; HT018; SEMAQ; SEMA6A1
Summary. The transmembrane semaphorin SEMA6A is expressed in developing neural tissue and is required for proper development of the thalamocortical projection (Leighton et al., 2001 [PubMed 11242070]).[supplied by OMIM, Feb 2011]
Expression Broad expression in adrenal (RPKM 13.5), placenta (RPKM 11.0) and 24 other tissues See more
Orthologs mouse all
Related articles in PubMed
  1. SEMA6A is a prognostic biomarker in glioblastoma. Zhao J, et al. Tumour Biol, 2015 Nov. PMID 26014517
  2. From plasma membrane to cytoskeleton: a novel function for semaphorin 6A. Prislei S, et al. Mol Cancer Ther, 2008 Jan. PMID 18187809
  3. Comparative integromics on non-canonical WNT or planar cell polarity signaling molecules: transcriptional mechanism of PTK7 in colorectal cancer and that of SEMA6A in undifferentiated ES cells. Katoh M, et al. Int J Mol Med, 2007 Sep. PMID 17671748
See all (31) citations in PubMed
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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?
  1. NANOG-, SOX2-, and POU5F1 (OCT3/OCT4)-binding sites within intron 1 of the SEMA6A gene



 (13) SEMA3D (7q21.11), Semaphorin 3D

Muita nimiä: Sema-Z2, coll-2 (collapsin family member). Tämä geenin koodaama proteiini sitoo neuropiliiniä ja on tärkeä kardiovaskulaarfisessa kehityksessä,.
https://www.ncbi.nlm.nih.gov/gene/223117
Also known as coll-2; Sema-Z2
Summary. This gene encodes a member of the semaphorin III family of secreted signaling proteins that are involved in axon guidance during neuronal develoent.pm The encoded protein contains an N-terminal Sema domain, an immunoglobulin like domain and a C-terminal basic domain. The protein encoded by this gene binds neuropilin and plays an important role in cardiovascular development. [provided by RefSeq, Aug 2016]
Expression. Biased expression in spleen (RPKM 23.4), thyroid (RPKM 18.9) and 13 other tissues See more
Related articles in PubMed
  1. Possible association of the semaphorin 3D gene (SEMA3D) with schizophrenia. Fujii T, et al. J Psychiatr Res, 2011 Jan. PMID 20684831
  2. Semaphorin profiling of periodontal fibroblasts and osteoblasts. Lallier TE. J Dent Res, 2004 Sep. PMID 15329371 OBS!
  3. CTNNA3 and SEMA3D: Promising loci for asthma exacerbation identified through multiple genome-wide association studies. McGeachie MJ, et al. J Allergy Clin Immunol, 2015 Dec. PMID 26073756, Free PMC Article
See all (19) citations in PubMed
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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?
  1. Observational study of gene-disease association. (HuGE Navigator)



 (14) SEMA6D (15q21.1) Semaphorin 6D

Muita nimiä: NC-000015-10
https://www.ncbi.nlm.nih.gov/gene/80031
Summary. Semaphorins are a large family, including both secreted and membrane associated proteins, many of which have been implicated as inhibitors or chemorepellents in axon pathfinding, fasciculation and branching, and target selection. All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Additional sequence motifs C-terminal to the semaphorin domain allow classification into distinct subfamilies. Results demonstrate that transmembrane semaphorins, like the secreted ones, can act as repulsive axon guidance cues. This gene encodes a class 6 vertebrate transmembrane semaphorin that demonstrates alternative splicing. Several transcript variants have been identified and expression of the distinct encoded isoforms is thought to be regulated in a tissue- and development-dependent manner. [provided by RefSeq, Nov 2010]
Expression
Broad expression in small intestine (RPKM 13.9), placenta (RPKM 10.4) and 19 other tissues See more
Related articles in PubMed
  1. Expression of semaphorin 6D in gastric carcinoma and its significance. Zhao XY, et al. World J Gastroenterol, 2006 Dec 7. PMID 17143962, Free PMC Article
  2. Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis. Takegahara N, et al. Nat Cell Biol, 2006 Jun. PMID 16715077
See all (20) citations in PubMed
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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?
  1. identification, characterization, and functional study of the two novel human members of the semaphorin gene family

(15)  SEMA4B 15q25.1. Semaphorin 4B

Muita nimiä: SEMAC, SemC ( vain lyhyt teksti)
SemC; SEMAC
Expression
Ubiquitous expression in esophagus (RPKM 24.0), skin (RPKM 20.0) and 25 other tissues See more
Related articles in PubMed
  1. SEMA4B inhibits growth of non-small cell lung cancer in vitro and in vivo. Jian H, et al. Cell Signal, 2015 Jun. PMID 25746385
  2. SEMA4b inhibits MMP9 to prevent metastasis of non-small cell lung cancer. Jian H, et al. Tumour Biol, 2014 Nov. PMID 25095981
  3. Sema domain of semaphorin 4B (SEMA4B), which is an interacting protein of LNM35, plays an important role in lung cancer invasion. However, the regulation mechanism of this protein is completely unknown. Here, we report that hypoxia and hypoxia mimic reagent could downregulate the expression of SEMA4B in human non-small cell lung cancer (NSCLC) lines. We provide evidences that SEMA4B is a direct target of hypoxia-inducible factor 1 (HIF-1). Silencing the expression of HIF-1α in cancer cells by RNA interference abolished hypoxia-repressed SEMA4B expression. Using luciferase reporter assay, we showed that HIF-1α recognized a hypoxia-responsive element (HRE) of SEMA4B gene, which is required for HIF-1-repressed SEMA4B expression. Moreover, ectopic expression of SEMA4B abolished invasion of hypoxia-induced NSCLC cells. Taken together, these data would shed novel insights on the mechanisms for invasion of hypoxia-induced NSCLC cells.
  4. CLCP1 interacts with semaphorin 4B and regulates motility of lung cancer cells. Nagai H, et al. Oncogene, 2007 Jun 7. PMID 17213806
  5. Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension. Püschel AW, et al. Neuron, 1995 May. PMID 7748561



(16)  SEMA4G , 10q24.31. Semaphorin 4G

Ei muita nimiä
https://www.ncbi.nlm.nih.gov/gene/57715

Summary Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Expression
Broad expression in duodenum (RPKM 18.5), small intestine (RPKM 15.9) and 20 other tissues See more

These findings provide evidence that the miR-608 rs4919510 polymorphism may modify cancer susceptibility in a type-specific manner. Furthermore, SEMA4G may function as an oncogene or tumour suppressor to regulate tumour development in a type-specific manner. Further studies with experimental evaluations are warranted.

(17) SEMA6B , ( 19p13.3) Semaphorin 6B

Muita nimiä: SEM-SEMA-Y, SEMA VIB,SEMAN, SemaZ. PPAR säätää tämän geenin vahvasti alas. Tällä geenillä on assosiaatioita tuumorien differentioitumiseen ja metasaasiin.
https://www.ncbi.nlm.nih.gov/gene/10501
Also known as SEMAN; semaZ; SEMA-VIB; SEM-SEMA-Y
Summary. This gene encodes a member of the semaphorin family, a group of proteins characterized by the presence of a conserved semaphorin (sema) domain. Whereas some semaphorins are transmembrane proteins, others are secreted. Semaphorins play a major role in axon guidance. The protein encoded by this gene may be involved in both peripheral and central nervous system development. [provided by RefSeq, Jul 2008]
Expression Broad expression in brain (RPKM 18.7), spleen (RPKM 8.6) and 15 other tissues See more
Orthologs mouse all
Related articles in PubMed
  1. Analysis of SEMA6B gene expression in breast cancer: identification of a new isoform. D'Apice L, et al. Biochim Biophys Acta, 2013 Oct. PMID 23665584
  2. The human semaphorin 6B gene is down regulated by PPARs. Collet P, et al. Genomics, 2004 Jun. PMID 15177567
  3. Signal peptide prediction based on analysis of experimentally verified cleavage sites. Zhang Z, et al. Protein Sci, 2004 Oct. PMID 15340161, Free PMC Article
See all (9) citations in PubMed
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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?
  1. Gene SEMA6B is strongly down regulated by peroxisome proliferator-activated receptors.

(18)  SEMA3G, (3p21.1), Semaphorin 3G

Muita nimiä: Sem2. Tämän geenin transkriptio aktivoituu PPAR-gammalla.
https://www.ncbi.nlm.nih.gov/gene/56920
Also known as sem2
Summary. The transcription of this gene is activated by PPAR-gamma, and the resulting protein product plays a role in endothelial cell migration. Expression of this gene also inhibits tumor cell migration and invasion. [provided by RefSeq, Jul 2016]
Expression
Biased expression in fat (RPKM 51.5), placenta (RPKM 13.3) and 10 other tissues See more
Orthologs
mouse all
Related articles in PubMed
  1. PPAR-γ promotes endothelial cell migration by inducing the expression of Sema3g. Liu W, et al. J Cell Biochem, 2015 Apr. PMID 25335934
  2. Effects of SEMA3G on migration and invasion of glioma cells. Zhou X, et al. Oncol Rep, 2012 Jul. PMID 22562223
  3. Differential endothelial transcriptomics identifies semaphorin 3G as a vascular class 3 semaphorin. Kutschera S, et al. Arterioscler Thromb Vasc Biol, 2011 Jan. PMID 20947821
See all (18) citations in PubMed
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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?
  1. Sema3G inhibits tumor progression from MDA-MB-435 but not from MDA-MB-231 cancer cells. It inhibits tumor angiogenesis in MDA-MB-231 cells.

(19)  SEMA5B, (3q21.1), Semaphorin 5B

Muita nimiä: SEMAG, SemG
https://www.ncbi.nlm.nih.gov/gene/54437
Also known as SemG; SEMAG
Summary. This gene encodes a member of the semaphorin protein family which regulates axon growth during development of the nervous system. The encoded protein has a characteristic Sema domain near the N-terminus, through which semaphorins bind to plexin, and five thrombospondin type 1 repeats in the C-terminal region of the protein. The protein product may be cleaved and exist as a secreted molecule (PMID: 19463192). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Expression. Broad expression in brain (RPKM 2.8), heart (RPKM 1.3) and 16 other tissues See more
Orthologs mouse all
Related articles in PubMed
  1. Semaphorin 5B mediates synapse elimination in hippocampal neurons. O'Connor TP, et al. Neural Dev, 2009 May 23. PMID 19463192, Free PMC Article
  2. Driver Gene and Novel Mutations in Asbestos-Exposed Lung Adenocarcinoma and Malignant Mesothelioma Detected by Exome Sequencing. Mäki-Nevala S, et al. Lung, 2016 Feb. PMID 26463840 Asbestos is a carcinogen linked to malignant mesothelioma (MM) and lung cancer. Some gene aberrations related to asbestos exposure are recognized, but many associated mutations remain obscure. We performed exome sequencing to determine the association of previously known mutations (driver gene mutations) with asbestos and to identify novel mutations related to asbestos exposure in lung adenocarcinoma (LAC) and MM.
  3. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 2000 Apr 28. PMID 10819331
See all (16) citations in PubMed
See citations in PubMed for homologs of this gene provided by HomoloGene
GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?
  1. Sema5B regulates the development and maintenance of synapse size and number in hippocampal neurons.



(20)  SEMA6C, ( 1q21.3) , Semaphorin 6C

Muita nimiä: SEMAY, m-SemaY, m-SemaY2 Semaforiinit edustavat tärkeitä molekulaarisia signaaleita keskushermostovaurion jälkeisissä soluvasteissa ja niillä voi olla tärkeä osuus neuraalisessa regeneraatiossa.

https://www.ncbi.nlm.nih.gov/gene/10500
Also known as SEMAY; m-SemaY; m-SemaY2
Summary: This gene encodes a member of the semaphorin family. Semaphorins represent important molecular signals controlling multiple aspects of the cellular response that follows CNS injury, and thus may play an important role in neural regeneration. [provided by RefSeq, May 2010]
Expression. Broad expression in testis (RPKM 9.5), heart (RPKM 5.4) and 20 other tissues See more
Orthologs mouse all
Related articles in PubMed
  1. Emerging roles for semaphorins in neural regeneration. Pasterkamp RJ, et al. Brain Res Brain Res Rev, 2001 Mar. PMID 11245885
  2. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 2001 Apr 27. PMID 11347906
See all (11) citations in PubMed
See citations in PubMed for homologs of this gene provided by HomoloGene



25.2. 2019 Muistiin  lähdetietoa semaforiineista. Koska tämä on aika uusi asia minulle, otin monta  esimerkkiä ja artikkelia. poistan myöhemmin osan ja jätän vain geenilinkin PubMed.



















































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