CD38 toimintatapa

Subsections:

1. GWAS Phenotypes
2. GO Terms
3. MGI/GenomeRNAi Phenotypes

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Molecular function for CD38 Gene according to UniProtKB/Swiss-Prot

Function:

• Synthesizes cyclic ADP-ribose (cADPR), a second messenger for glucose-induced insulin secretion (PubMed:8253715, 7961800).
  Synthesizes the Ca(2+) mobilizer nicotinate-adenine dinucleotide phosphate, NAADP(+), from 2'-phospho-cADPR and nicotinic acid, as well as from NADP(+) and nicotinic acid.
  At both pH 5.0 and pH 7.4 preferentially transforms 2'-phospho-cADPR into NAADP(+), while preferentially cleaving NADP(+) to cADPR and ADPRP rather than into NADDP(+) (PubMed:16690024).
  Has cADPR hydrolase activity (PubMed:8253715, 7961800). CD38_HUMAN,P28907

CatalyticActivity:

• Reaction=2'-phospho-cyclic ADP-ribose + nicotinate = nicotinate-adenine dinucleotide phosphate; Xref=RHEA:38607, CHEBI:32544, CHEBI:75967, CHEBI:75970; Evidence={ECO:0000269 PubMed:16690024}. CD38_HUMAN,P28907
• Reaction=NAD(+) = cyclic ADP-beta-D-ribose + H(+) + nicotinamide; Xref=RHEA:38611, CHEBI:15378, CHEBI:17154, CHEBI:57540, CHEBI:73672; Evidence={ECO:0000269 PubMed:7961800, 8253715}. CD38_HUMAN,P28907
• Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide; Xref=RHEA:16301, CHEBI:15377, CHEBI:15378, CHEBI:17154, CHEBI:57540, CHEBI:57967; EC=3.2.2.6; Evidence={ECO:0000269 PubMed:16690024, 8253715}. CD38_HUMAN,P28907
• Reaction=cyclic ADP-beta-D-ribose + H2O = ADP-D-ribose; Xref=RHEA:38615, CHEBI:15377, CHEBI:57967, CHEBI:73672; Evidence={ECO:0000269 PubMed:7961800, 8253715}. CD38_HUMAN,P28907
• Reaction=NADP(+) = 2'-phospho-cyclic ADP-ribose + nicotinamide; Xref=RHEA:38603, CHEBI:17154, CHEBI:58349, CHEBI:75970; Evidence={ECO:0000269 PubMed:16690024}. CD38_HUMAN,P28907
• Reaction=NADP(+) + nicotinate = nicotinamide + nicotinate-adenine dinucleotide phosphate; Xref=RHEA:38599, CHEBI:17154, CHEBI:32544, CHEBI:58349, CHEBI:75967; EC=2.4.99.20; Evidence={ECO:0000305 PubMed:16690024}. CD38_HUMAN,P28907

BiophysicochemicalProperties:

• pH dependence: Optimum pH for NAADP(+) production is 5.0 from either substrate, activity is much higher at pH 5.0 than 7.4.
  {ECO:0000269 PubMed:16690024}; CD38_HUMAN,P28907

EnzymeRegulation:

• ATP inhibits the cADPR hydrolyzing activity. CD38_HUMAN,P28907

Molecular function for CD38 Gene according to GENATLAS

Biochemistry:

• cell differentiation antigen CD38 (T10),45kDa,membrane glycoprotein,integral,identified by monoclonal antibody OKT10,HB-7,homolog to Aplysia ADRC gene,involved in insulin secretion through mobi-calcium of mobilisation CD38

Enzyme Numbers (IUBMB) for CD38 Gene

• EC 3.2.2.- ⁴
• EC 3.2.2.6 ⁴
• EC 2.4.99.20 ⁴