MZF1 (19q13.43), ZNF42. ZSCAN6, SCAN domainin (leusiinipitoinen) sisältävä C2H2-tyyppinen Zf

http://ar.iiarjournals.org/search?fulltext=myeloid+zinc+finger+1+(MZF1)&sortspec=date&submit=Submit&andorexactfulltext=phrase
Mihin sinkkisormiproteiiniryhmään tämä kuuluu? MZF1

Experimental Studies

Myeloid Zinc Finger 1 (MZF1) Maintains the Mesenchymal Phenotype by Down-regulating IGF1R/p38 MAPK/ERα Signaling Pathway in High-level MZF1-expressing TNBC cells Anticancer Res August 2019 39 (8) 4149-4164; doi:10.21873/anticanres.13574 
 

...Myeloid Zinc Finger 1 (MZF1) Maintains the Mesenchymal Phenotype by Down-regulating IGF1R/p38 MAPK/ER Signaling Pathway in High-level MZF1-expressing TNBC cells CHIA-HERNG YUE1,2, JER-YUH LIU3,4, CHING-SHIANG CHI5, CHING-WEN HU6, KOK-TONG TAN1, FU-MEI HUANG7, YING-RU PAN8, KUN-I LIN9,10 and CHIA ...

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HAKU 5.9. 2019
 Geeni MZF1 (19q13.43)
https://www.ncbi.nlm.nih.gov/gene/7593

Also known as

MZF-1; MZF1B; ZFP98; ZNF42; ZSCAN6

Expression

Ubiquitous expression in spleen (RPKM 4.6), prostate (RPKM 4.2) and 25 other tissues See more

Orthologs

 

Preferred Names

myeloid zinc finger 1

Names

zinc finger and SCAN domain-containing protein 6

zinc finger protein 42 (myeloid-specific retinoic acid-responsive)

NM_003422.2 → NP_003413.2  myeloid zinc finger 1 isoform 1

onserved Domains (4) summary

smart00431
Location:40 → 152

SCAN; leucine rich region

SCAN domain

The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several pfam00096 proteins. The domain has been shown to be able to mediate homo- and hetero-oligomerization.

• Isolation and characterization of a novel zinc-finger protein with transcription repressor activity.J. Biol. Chem. 1995 Sep 22; 270(38):22143-52
• The zinc finger-associated SCAN box is a conserved oligomerization domain.Mol. Cell. Biol. 1999 Dec ; 19(12):8526-35Abstract
  

  A number of Cys(2)His(2) zinc finger proteins contain a highly conserved amino-terminal motif termed the SCAN domain. This element is an 80-residue, leucine-rich region that contains three segments strongly predicted to be alpha-helices. In this report, we show that the SCAN motif functions as an oligomerization domain mediating self-association or association with other proteins bearing SCAN domains. These findings suggest that the SCAN domain plays an important role in the assembly and function of this newly defined subclass of transcriptional regulators.

COG5048
Location:358 → 716

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:543 → 563

ZF_C2H2; C2H2 Zn finger [structural motif]

sd00019
Location:442 → 462

ZF_C2H2; C2H2 Zn finger [structural motif]