GCP16, golgiini A on yksi golgiiniperheen jäsenistä (8p11.21). vaikuttaa siltä että tämän perheen jäsenet tekevät synkronisoitua funtiota Golgin laitteessa ja assosiaatiota on mm. sinkkisormiproteiinin, joka on tyyppiä DHHC. Maintiaan ZDHHC9- GOLGA7 kompleksi, joka vastatoimii palmityylitranbsferaasina H-Ras ja N-Ras proteiineille.
What's a GeneRIF?
- Official Symbol
- GOLGA7
- Official Full Name
- golgin A7
- Also known as
- GCP16; GOLGA7A; HSPC041; GOLGA3AP1
- Expression
- Ubiquitous expression in brain (RPKM 33.3), testis (RPKM 26.7) and 25 other tissues See more
- Orthologs
- mouse al
- Identification and characterization of GCP16, a novel acylated Golgi protein that interacts with GCP170. Ohta E, et al. J Biol Chem, 2003 Dec 19. PMID 14522980https://www.ncbi.nlm.nih.gov/pubmed/14522980/, https://www.ncbi.nlm.nih.gov/gene/2802
- DHHC9 and GCP16 constitute a human protein fatty acyltransferase with specificity for H- and N-Ras. Swarthout JT, et al. J Biol Chem, 2005 Sep 2. PMID 16000296
- Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras. Wang T, et al. Cell, 2017 Feb 23. PMID 28162770, Free PMC Article
- Gene expression profile of human bone marrow stromal cells: high-throughput expressed sequence tag sequencing analysis. Jia L, et al. Genomics, 2002 Jan. PMID 11827452
- Protein phosphatase 1γ isoforms linked interactions in the brain. Esteves SL, et al. J Mol Neurosci, 2013 May. PMID 23080069
- Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
- Observational study of gene-disease association. (HuGE Navigator)
- results indicate that GCP16 is the acylated membrane protein, associated with GCP170, and possibly involved in vesicular transport from the Golgi to the cell surface
- Data show that H- and N-Ras are palmitoylated by a human protein palmitoyltransferase encoded by the ZDHHC9 and GCP16 genes.
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