KLHL32 (6q16.1 ) , BKLHD5, KIAA1900, dJ21F7.1

http://www.ebi.ac.uk/interpro/entry/InterPro/IPR030570/

Description

Kelch-like protein 32 (KLHL32) belongs to the KLHL family ( KLHL family members belong to the N-dimer, C-propeller subclass of Kelch repeat proteins)

^[1]. Its function is not clear.( Expression: Brain  https://www.proteinatlas.org/ENSG00000186231-KLHL32/tissue

The KLHL (Kelch-like) proteins generally have a BTB/POZ domain, a BACK domain, and five to six Kelch motifs. They constitute a subgroup at the intersection between the BTB/POZ domain and Kelch domain superfamilies. The BTB/POZ domain facilitates protein binding

^[1], while the Kelch domain (repeats) form beta-propellers.  

        10         20         30         40         50
MPSERCLSIQ EMLTGQRLCH SESHNDSVLA ALNQQRSDGI LCDITLIAEE 
        60         70         80         90        100
QKFHAHKAVL AACSDYFRAM FSLCMVESGA DEVNLHGVTS LGLKQALEFA 
       110        120        130        140        150
YTGQILLEPG VIQDVLAAGS HLQLLELLNL CSHYLIQELN SFNYLDLYRL 
       160        170        180        190        200
ADLFNLTLLE KAVIDFLVKH LSELLKSRPE EVLTLPYCLL QEVLKSDRLT 
       210        220        230        240        250
SLSEEQIWQL AVRWLEHNCH YQYMDELLQY IRFGLMDVDT LHTVALSHPL 
       260        270        280        290        300
VQASETATAL VNEALEYHQS IYAQPVWQTR RTKPRFQSDT LYIIGGKKRE 
       310        320        330        340        350
VCKVKELRYF NPVDQENALI AAIANWSELA PMPVGRSHHC VAVMGDFLFV 
       360        370        380        390        400
AGGEVEHASG RTCAVRTACR YDPRSNSWAE IAPMKNCREH FVLGAMEEYL 
       410        420        430        440        450
YAVGGRNELR QVLPTVERYC PKKNKWTFVQ SFDRSLSCHA GYVADGLLWI 
       460        470        480        490        500
SGGVTNTAQY QNRLMVYEPN QNKWISRSPM LQRRVYHSMA AVQRKLYVLG 
       510        520        530        540        550
GNDLDYNNDR ILVRHIDSYN IDTDQWTRCN FNLLTGQNES GVAVHNGRIY 
       560        570        580        590        600
LVGGYSIWTN EPLACIQVLD VSREGKEEVF YGPTLPFASN GIAACFLPAP 
       610        620
YFTCPNLQTL QVPHHRIGTI      

 LxxLL
 EQL

1, resulting in an isoform (b) that is shorter than isoform a.

Source sequence(s)

AB067487, AK295479, DA296671, DC314842

Consensus CDS

CCDS69154.1

UniProtKB/Swiss-Prot

Q96NJ5

Related

ENSP00000440382.1, ENST00000536676.5

Conserved Domains (7) summary

smart00612
Location:255 → 310

Kelch; Kelch domain

smart00875
Location:108 → 208

BACK; BTB And C-terminal Kelch

PHA03098
Location:30 → 554

PHA03098; kelch-like protein; Provisional

sd00038
Location:300 → 348

Kelch; KELCH repeat [structural motif]

pfam00651
Location:32 → 132

BTB; BTB/POZ domain

pfam01344
Location:447 → 493

Kelch_1; Kelch motif

pfam13964
Location:300 → 352

Kelch_6; Kelch motif

(The Kelch superfamily of proteins can be subdivided into five groups: 

(1) N-propeller, C-dimer proteins, 

(2) N-propeller proteins,

 (3) propeller proteins,

 (4) N-dimer, C-propeller proteins,   ( Tämä KLHL32 kuuluu niihin joilla on N-dimeeri ja C-propellit)

 (5) C-propeller proteins.

^[2]

. In addition to BTB/POZ and Kelch domains, the KLHL family members contain a BACK domain, first described as a 130-residue region of conservation observed amongst BTB-Kelch proteins

^[3]. Many of the Kelch-like proteins have been identified as adaptors for the recruitment of substrates to Cul3-based E3 ubiquitin ligases ^{[4, 5]}

.

Contributing Member Database Entr