TRIM72 (Kr.16p11.2) MG53, Mitsugumin-53, (C_IV, PRY_SPRY)

TRIM72, (Kr.16p11.2), MG53, mitsugumin-53.

https://www.ncbi.nlm.nih.gov/protein/NP_001008275.2

tripartite motif-containing protein 72 [Homo sapiens]

NCBI Reference Sequence: NP_001008275.2
Identical Proteins FASTA Graphics

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LOCUS       NP_001008275             477 aa            linear   PRI 02-OCT-2017
DEFINITION  tripartite motif-containing protein 72 [Homo sapiens].
ACCESSION   NP_001008275
VERSION     NP_001008275.2
DBSOURCE    REFSEQ: accession NM_001008274.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 477)
  AUTHORS   Lemckert FA, Bournazos A, Eckert DM, Kenzler M, Hawkes JM, Butler
            TL, Ceely B, North KN, Winlaw DS, Egan JR and Cooper ST.
  TITLE     Lack of MG53 in human heart precludes utility as a biomarker of
            myocardial injury or endogenous cardioprotective factor
  JOURNAL   Cardiovasc. Res. 110 (2), 178-187 (2016)
   PUBMED   26790476
  REMARK    GeneRIF: MG53 is an effective biomarker of myocardial injury and
            dysfunction in murine hearts. However, MG53 is not expressed in
            human heart and therefore does not hold utility as a clinical
            biomarker of myocardial injury
REFERENCE   2  (residues 1 to 477)
  AUTHORS   Li H, Duann P, Lin PH, Zhao L, Fan Z, Tan T, Zhou X, Sun M, Fu M,
            Orange M, Sermersheim M, Ma H, He D, Steinberg SM, Higgins R, Zhu
            H, John E, Zeng C, Guan J and Ma J.
  TITLE     Modulation of wound healing and scar formation by MG53
            protein-mediated cell membrane repair
  JOURNAL   J. Biol. Chem. 290 (40), 24592-24603 (2015)
   PUBMED   26306047
  REMARK    GeneRIF: MG53 is a facilitator of rapid injury repair, a mediator
            of cell migration, and a modulator of myofibroblast differentiation
            during wound healing
REFERENCE   3  (residues 1 to 477)
  AUTHORS   Cai C, Lin P, Zhu H, Ko JK, Hwang M, Tan T, Pan Z, Korichneva I and
            Ma J.
  TITLE     Zinc Binding to MG53 Protein Facilitates Repair of Injury to Cell
            Membranes
  JOURNAL   J. Biol. Chem. 290 (22), 13830-13839 (2015)
   PUBMED   25869134
  REMARK    GeneRIF: Zn(2+) interacts with MG53 in protection against injury to
            the cell membrane
REFERENCE   4  (residues 1 to 477)
  AUTHORS   Nguyen N, Yi JS, Park H, Lee JS and Ko YG.
  TITLE     Mitsugumin 53 (MG53) ligase ubiquitinates focal adhesion kinase
            during skeletal myogenesis
  JOURNAL   J. Biol. Chem. 289 (6), 3209-3216 (2014)
   PUBMED   24344130
  REMARK    GeneRIF: MG53 induces FAK ubiquitination with the aid of UBE2H
            during skeletal myogenesis.
REFERENCE   5  (residues 1 to 477)
  AUTHORS   Alloush J and Weisleder N.
  TITLE     TRIM proteins in therapeutic membrane repair of muscular dystrophy
  JOURNAL   JAMA Neurol 70 (7), 928-931 (2013)
   PUBMED   23699904
  REMARK    GeneRIF: MG53/TRIM72 protein can be directly applied as a
            therapeutic agent to increase membrane repair capacity of many cell
            types.
            Review article
REFERENCE   6  (residues 1 to 477)
  AUTHORS   Zhu H, Lin P, De G, Choi KH, Takeshima H, Weisleder N and Ma J.
  TITLE     Polymerase transcriptase release factor (PTRF) anchors MG53 protein
            to cell injury site for initiation of membrane repair
  JOURNAL   J. Biol. Chem. 286 (15), 12820-12824 (2011)
   PUBMED   21343302
  REMARK    GeneRIF: membrane-delimited interaction between MG53 and PTRF
            contributes to initiation of cell membrane repair
REFERENCE   7  (residues 1 to 477)
  AUTHORS   Jung SY and Ko YG.
  TITLE     TRIM72, a novel negative feedback regulator of myogenesis, is
            transcriptionally activated by the synergism of MyoD (or myogenin)
            and MEF2
  JOURNAL   Biochem. Biophys. Res. Commun. 396 (2), 238-245 (2010)
   PUBMED   20399744
REFERENCE   8  (residues 1 to 477)
  AUTHORS   Park EY, Kwon OB, Jeong BC, Yi JS, Lee CS, Ko YG and Song HK.
  TITLE     Crystal structure of PRY-SPRY domain of human TRIM72
  JOURNAL   Proteins 78 (3), 790-795 (2010)
   PUBMED   19967786
  REMARK    GeneRIF: Crystal structure of PRY-SPRY domain of human TRIM72.
REFERENCE   9  (residues 1 to 477)
  AUTHORS   Han S, Kim-Howard X, Deshmukh H, Kamatani Y, Viswanathan P,
            Guthridge JM, Thomas K, Kaufman KM, Ojwang J, Rojas-Villarraga A,
            Baca V, Orozco L, Rhodes B, Choi CB, Gregersen PK, Merrill JT,
            James JA, Gaffney PM, Moser KL, Jacob CO, Kimberly RP, Harley JB,
            Bae SC, Anaya JM, Alarcon-Riquelme ME, Matsuda K, Vyse TJ and Nath
            SK.
  TITLE     Evaluation of imputation-based association in and around the
            integrin-alpha-M (ITGAM) gene and replication of robust association
            between a non-synonymous functional variant within ITGAM and
            systemic lupus erythematosus (SLE)
  JOURNAL   Hum. Mol. Genet. 18 (6), 1171-1180 (2009)
   PUBMED   19129174
  REMARK    GeneRIF: Observational study and meta-analysis of gene-disease
            association. (HuGE Navigator)
REFERENCE   10 (residues 1 to 477)
  AUTHORS   Martin J, Han C, Gordon LA, Terry A, Prabhakar S, She X, Xie G,
            Hellsten U, Chan YM, Altherr M, Couronne O, Aerts A, Bajorek E,
            Black S, Blumer H, Branscomb E, Brown NC, Bruno WJ, Buckingham JM,
            Callen DF, Campbell CS, Campbell ML, Campbell EW, Caoile C,
            Challacombe JF, Chasteen LA, Chertkov O, Chi HC, Christensen M,
            Clark LM, Cohn JD, Denys M, Detter JC, Dickson M,
            Dimitrijevic-Bussod M, Escobar J, Fawcett JJ, Flowers D, Fotopulos
            D, Glavina T, Gomez M, Gonzales E, Goodstein D, Goodwin LA, Grady
            DL, Grigoriev I, Groza M, Hammon N, Hawkins T, Haydu L, Hildebrand
            CE, Huang W, Israni S, Jett J, Jewett PB, Kadner K, Kimball H,
            Kobayashi A, Krawczyk MC, Leyba T, Longmire JL, Lopez F, Lou Y,
            Lowry S, Ludeman T, Manohar CF, Mark GA, McMurray KL, Meincke LJ,
            Morgan J, Moyzis RK, Mundt MO, Munk AC, Nandkeshwar RD, Pitluck S,
            Pollard M, Predki P, Parson-Quintana B, Ramirez L, Rash S, Retterer
            J, Ricke DO, Robinson DL, Rodriguez A, Salamov A, Saunders EH,
            Scott D, Shough T, Stallings RL, Stalvey M, Sutherland RD, Tapia R,
            Tesmer JG, Thayer N, Thompson LS, Tice H, Torney DC, Tran-Gyamfi M,
            Tsai M, Ulanovsky LE, Ustaszewska A, Vo N, White PS, Williams AL,
            Wills PL, Wu JR, Wu K, Yang J, Dejong P, Bruce D, Doggett NA,
            Deaven L, Schmutz J, Grimwood J, Richardson P, Rokhsar DS, Eichler
            EE, Gilna P, Lucas SM, Myers RM, Rubin EM and Pennacchio LA.
  TITLE     The sequence and analysis of duplication-rich human chromosome 16
  JOURNAL   Nature 432 (7020), 988-994 (2004)
   PUBMED   15616553
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA821604.1, AC009088.9, AK131485.1 and DA058421.1.
            On Dec 4, 2009 this sequence version replaced NP_001008275.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK131485.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2158800, SAMEA2162946
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     Protein         1..477
                     /product="tripartite motif-containing protein 72"
                     /note="mitsugumin-53; tripartite motif containing 72, E3
                     ubiquitin protein ligase"
                     /calculated_mol_wt=52600
     Region          11..57
                     /region_name="RING-HC_TRIM72_C-IV"
                     /note="RING finger, HC subclass, found in tripartite
                     motif-containing protein 72 (TRIM72) and similar proteins;
                     cd16612"
                     /db_xref="CDD:319526"
     Region          14..56
                     /region_name="RING-HC finger (C3HC4-type)"
                     /note="RING-HC finger (C3HC4-type) [structural motif]"
                     /db_xref="CDD:319526"
     Site            order(14,17,29,31,34,37,53,56)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:319526"
     Region          81..121
                     /region_name="zf-B_box"
                     /note="B-box zinc finger; pfam00643"
                     /db_xref="CDD:306989"
     Site            order(86,89,108,114)
                     /site_type="other"
                     /note="Zn2+ binding site [ion binding]"
                     /db_xref="CDD:237988"
     Site            144
                     /site_type="nitrosylation"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="S-nitrosocysteine. {ECO:0000269|PubMed:24487118};
                     propagated from UniProtKB/Swiss-Prot (Q6ZMU5.2)"
     Site            255
                     /site_type="phosphorylation"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000250|UniProtKB:A0JPQ4};
                     propagated from UniProtKB/Swiss-Prot (Q6ZMU5.2)"
     Region          278..470
                     /region_name="SPRY_PRY_TRIM72"
                     /note="PRY/SPRY domain in tripartite motif-binding protein
                     72 (TRIM72); cd13742"
                     /db_xref="CDD:293976"
     CDS             1..477
                     /gene="TRIM72"
                     /gene_synonym="MG53"
                     /coded_by="NM_001008274.3:285..1718"
                     /db_xref="CCDS:CCDS32437.1"
                     /db_xref="GeneID:493829"
                     /db_xref="HGNC:HGNC:32671"
                     /db_xref="MIM:613288"
ORIGIN      
        1 msaapgllhq elscplclql fdapvtaecg hsfcraclgr vagepaadgt vlcpccqapt
       61 rpqalstnlq larlveglaq vpqghceehl dplsiyceqd ralvcgvcas lgshrghrll
      121 paaeaharlk tqlpqqklql qeacmrkeks vavlehqlve veetvrqfrg avgeqlgkmr
      181 vflaalegsl dreaervrge agvalrrelg slnsyleqlr qmekvleeva dkpqteflmk
      241 yclvtsrlqk ilaespppar ldiqlpiisd dfkfqvwrkm fralmpalee ltfdpssahp
      301 slvvsssgrr vecseqkapp agedprqfdk avavvahqql segehywevd vgdkprwalg
      361 viaaeaprrg rlhavpsqgl wllglregki leahveakep ralrsperrp triglylsfg
      421 dgvlsfydas dadalvplfa fherlprpvy pffdvcwhdk gknaqplllv gpegaea
//

Sivulinkki: S-Nitroso-cystein?

https://link.springer.com/protocol/10.1007%2F978-1-59745-198-7_155

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