TRIM64 on nimetty myös TRIM64 A ja C11orf28 nimillä, merkintöjä rakenteesta vuodesta 2008 alkaen.
- TRIM64, also known TRIM64A; C11orf28
- Expression Low expression observed in reference dataset See more
- Orthologs all
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Identification of a genomic reservoir for new TRIM genes in primate genomes. Han K, et al. PLoS Genet, 2011 Dec. PMID 22144910, Free PMC Article
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Human
chromosome 11 DNA sequence and analysis including novel gene
identification. Taylor TD, et al. Nature, 2006 Mar 23.
PMID 16554811
UUSI geeni. Rakenne selvitetty , TRIM64 peptidissä on 499 aminohappoa
- Conserved Domains (4) summary
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cd00021
Location:91 → 128 - BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
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pfam04803
Location:141 → 229 - Cor1; Cor1/Xlr/Xmr conserved region
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cl02614
Location:284 → 445 - SPRY; SPRY domain
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cl17238
Location:15 → 55 - RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
tripartite motif-containing protein 64 [Homo sapiens]
NCBI Reference Sequence:
NP_001129958.1LOCUS NP_001129958 449 aa linear PRI 08-APR-2018 DEFINITION tripartite motif-containing protein 64 [Homo sapiens]. ACCESSION NP_001129958 XP_061890 VERSION NP_001129958.1 DBSOURCE REFSEQ: accession NM_001136486.1 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (residues 1 to 449) AUTHORS Han K, Lou DI and Sawyer SL. TITLE Identification of a genomic reservoir for new TRIM genes in primate genomes JOURNAL PLoS Genet. 7 (12), e1002388 (2011) PUBMED 22144910 REFERENCE 2 (residues 1 to 449) AUTHORS Taylor TD, Noguchi H, Totoki Y, Toyoda A, Kuroki Y, Dewar K, Lloyd C, Itoh T, Takeda T, Kim DW, She X, Barlow KF, Bloom T, Bruford E, Chang JL, Cuomo CA, Eichler E, FitzGerald MG, Jaffe DB, LaButti K, Nicol R, Park HS, Seaman C, Sougnez C, Yang X, Zimmer AR, Zody MC, Birren BW, Nusbaum C, Fujiyama A, Hattori M, Rogers J, Lander ES and Sakaki Y. TITLE Human chromosome 11 DNA sequence and analysis including novel gene identification JOURNAL Nature 440 (7083), 497-500 (2006) PUBMED 16554811 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AP004607.4. On Oct 31, 2008 this sequence version replaced XP_061890.10. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA2142853 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology ##RefSeq-Attributes-END## FEATURES Location/Qualifiers source 1..449 /organism="Homo sapiens" /db_xref="taxon:9606" /chromosome="11" /map="11q14.3" Protein 1..449 /product="tripartite motif-containing protein 64" /calculated_mol_wt=51435 Region 15..55 /region_name="RING" /note="RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; cl17238" /db_xref="CDD:302633" https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=302633 Site order(15,18,30,32,35,38,52,55) /site_type="other" /note="cross-brace motif" /db_xref="CDD:238093" Region 91..128 /region_name="BBOX" /note="B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; cd00021" /db_xref="CDD:237988" Site order(92,95,114,120) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:237988" Region 141..>229 /region_name="Cor1" /note="Cor1/Xlr/Xmr conserved region; pfam04803" /db_xref="CDD:282637" Region 284..445 /region_name="SPRY" /note="SPRY domain; cl02614" /db_xref="CDD:295394" CDS 1..449 /gene="TRIM64" /gene_synonym="C11orf28; TRIM64A" /coded_by="NM_001136486.1:1..1350" /db_xref="CCDS:CCDS73363.1" /db_xref="GeneID:120146" /db_xref="HGNC:HGNC:14663" ORIGIN 1 mdsddlqvfq neliccicvn yfidpvtidc ghsfcrpclc lcseegrapm rcpscrkise 61 kpnfntnvvl kklsslarqt rpqninssdn icvlheetke lfceadkrll cgpcsespeh 121 mahshspigw aaeecrekli kemdylwein qetrnnlnqe trtfhslkdy vsvrkriiti 181 qyqkmpifld eeeqrhlqal ereaeelfqq lqdsqvrmtq hlermkdmyr elwetchvpd 241 vellqdvrnv sartdlaqmq kpqpvnpelt swcitgvldm lnnfrvdsal stemipcyis 301 lsedvryvif gddhlsaptd pqgvdsfavw gaqaftsgkh ywevdvtlss nwilgvcqds 361 rtadanfvid sderffliss krsnhyslst nsppliqyvq rplgqvgvfl dydngsvsff 421 dvskgsliyg fppssfsspl rpffcfgct //
- Muistiin uudesta TRIM64 geenistä. 18.4. 2018
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