TRIM51 (Kr.11q12.1) , SPRYD, TRIM51A (C, luokittelematon)

TRIM51 (Kr.11pRelated articles in PubMed

https://www.ncbi.nlm.nih.gov/gene/84767

Tästä TRIM51 ei ole ihmistä koskevia kliinisiä artikkeleita. Geeni kuuluu TRIM-klusteriin ja on ilmisesti kromosomi 11 geenipankin yksi  evoluution alainen geeni ja sijaitsee lähellä sentromeeriä. Rakenteeltaan tämä TRIM51 on luokittelematon ja sen toinen nimi on SPRYD5, joka viittaa C-terminaaliseen SPRY-domeeniin . Geenitietueen informaatio liitetty.

Yleistä evolutionaalista  geenitiedetä koskevaa  on liitetty tähän tyhjään kohtaan  PubMedissä - teksteisä saa käsityksen näiden genien evoluutionalaisuudesta.  Ehkä niitä on varalla uusia haasteita odottamassa.

1. Identification of a genomic reservoir for new TRIM genes in primate genomes. Han K, et al. PLoS Genet, 2011 Dec. PMID 22144910, Free PMC Article
2. Towards a proteome-scale map of the human protein-protein interaction network. Rual JF, et al. Nature, 2005 Oct 20. PMID 16189514
3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
   

TRIM51 geenin koodaaman proteiinin rakenne (PubMed GENE) Konservoidut domeenit:

cl02614
Location:285 → 448

SPRY; SPRY domain

cl17238
Location:15 → 45

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

GenPept

TRIM51 peptidirakenne

tripartite motif-containing protein 51 [Homo sapiens]

NCBI Reference Sequence: NP_116070.2
Identical Proteins FASTA Graphics

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LOCUS       NP_116070                452 aa            linear   PRI 08-APR-2018
DEFINITION  tripartite motif-containing protein 51 [Homo sapiens].
ACCESSION   NP_116070
VERSION     NP_116070.2
DBSOURCE    REFSEQ: accession NM_032681.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 452)
  AUTHORS   Han K, Lou DI and Sawyer SL.
  TITLE     Identification of a genomic reservoir for new TRIM genes in primate
            genomes
  JOURNAL   PLoS Genet. 7 (12), e1002388 (2011)
   PUBMED   22144910
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC036111.7, DV080293.1 and BC005014.1.
            On Oct 21, 2008 this sequence version replaced NP_116070.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed/partial sample support SAMEA1968968,
                              SAMEA2145743 [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..452
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.1"
     Protein         1..452
                     /product="tripartite motif-containing protein 51"
                     /note="SPRY domain-containing protein 5; SPRY domain
                     containing 5"
                     /calculated_mol_wt=52154
     Site            order(15,18,30,32,35,38,52,55)
                     /site_type="other"
                     /note="cross-brace motif"
                     /db_xref="CDD:238093"
     Region          15..>45
                     /region_name="RING"
                     /note="RING-finger (Really Interesting New Gene) domain, a
                     specialized type of Zn-finger of 40 to 60 residues that
                     binds two atoms of zinc; defined by the 'cross-brace'
                     motif C-X2-C-X(9-39)-C-X(1-3)-
                     H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved
                     in...; cl17238"
                     /db_xref="CDD:302633"
     Region          285..448
                     /region_name="SPRY"
                     /note="SPRY domain; cl02614"
                     /db_xref="CDD:295394"
     CDS             1..452
                     /gene="TRIM51"
                     /gene_synonym="SPRYD5; TRIM51A"
                     /coded_by="NM_032681.3:93..1451"
                     /db_xref="GeneID:84767"
                     /db_xref="HGNC:HGNC:19023"
ORIGIN      
        1 mnsgilqvfq raltcpicmn yfldpvtidc ghsfcrpcly lnwqdtavla qcseckkttr
       61 qrnlntdicl knmafiarka slrqflssee qicgmhretk kmfcevdksl lclpcsnsqe
      121 hrnhihcpie waaeerreel lkkmqslwek acenlrnlnm ettrtrcwkd yvslrieair
      181 aeyqkmpafl heeeqhhler lrkegedifq qlneskarme hsrellrgmy edlkqmchka
      241 dvellqafgd ilhryeslll qvsepvnpel sagpitglld slsgfrvdft lqperanshi
      301 flcgdlrsmn vgcdpqddpd itgksecflv wgaqaftsgk yywevhmgds wnwafgvcnn
      361 ywkekrqndk idgeeglfll gcvkedthcs lfttsplvvq yvprptstvg lfldcegrtv
      421 sfvdvdqssl iytipncsfs pplrpifccs hf
//

Muistiin 17,4, 2018 kromosomi 11:n TRIMgeeneistä