TRIM16 (Kr17p12.1) EBBP(estrogen-responsive B-box protein) Isoformi a rakenne

 Uusi tieto -Lisäys 23-11- 2019
https://pubmed.ncbi.nlm.nih.gov/30143514-trim16-controls-assembly-and-degradation-of-protein-aggregates-by-modulating-the-p62-nrf2-axis-and-autophagy/?from_term=kelch+protein&from_pos=7



KROMOSOMI 17

TRIM16, EBBP, estrogen-responsive B-box protein (EBBP)

TRIM16 (Kr.17p112) Isoformi a

-1..564 aminohappoa.

https://www.ncbi.nlm.nih.gov/pubmed/27693506/

tripartite motif-containing protein 16 isoform a [Homo sapiens]

NCBI Reference Sequence: NP_001335048.1
Identical Proteins FASTA Graphics

Go to:

LOCUS       NP_001335048             564 aa            linear   PRI 28-MAR-2018
DEFINITION  tripartite motif-containing protein 16 isoform a [Homo sapiens].
ACCESSION   NP_001335048
VERSION     NP_001335048.1
DBSOURCE    REFSEQ: accession NM_001348119.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 564)
  AUTHORS   Tan,H., Qi,J., Chu,G. and Liu,Z.
  TITLE     Tripartite Motif 16 Inhibits the Migration and Invasion in Ovarian
            Cancer Cells
  JOURNAL   Oncol. Res. 25 (4), 551-558 (2017)
   PUBMED   27737724
  REMARK    GeneRIF: TRIM16 inhibits the migration and invasion via suppressing
            the Sonic hedgehog signaling pathway in ovarian cancer cells.
REFERENCE   2  (residues 1 to 564)
  AUTHORS   Kimura T, Jia J, Kumar S, Choi SW, Gu Y, Mudd M, Dupont N, Jiang S,
            Peters R, Farzam F, Jain A, Lidke KA, Adams CM, Johansen T and
            Deretic V.
  TITLE     Dedicated SNAREs and specialized TRIM cargo receptors mediate
            secretory autophagy
  JOURNAL   EMBO J. 36 (1), 42-60 (2017)
   PUBMED   27932448
REFERENCE   3  (residues 1 to 564)
  AUTHORS   Qi L, Lu Z, Sun YH, Song HT and Xu WK.
  TITLE     TRIM16 suppresses the progression of prostate tumors by inhibiting
            the Snail signaling pathway
  JOURNAL   Int. J. Mol. Med. 38 (6), 1734-1742 (2016)
   PUBMED   27748839
  REMARK    GeneRIF: TRIM16 expression is decreased in prostate cancer tissues
            and overexpression of TRIM16 inhibits cell migration, invasion and
            the EMT process in vitro in prostate cancer through the
            transcription factor Snail.
REFERENCE   4  (residues 1 to 564)
  AUTHORS   Chauhan S, Kumar S, Jain A, Ponpuak M, Mudd MH, Kimura T, Choi SW,
            Peters R, Mandell M, Bruun JA, Johansen T and Deretic V.
  TITLE     TRIMs and Galectins Globally Cooperate and TRIM16 and Galectin-3
            Co-direct Autophagy in Endomembrane Damage Homeostasis
  JOURNAL   Dev. Cell 39 (1), 13-27 (2016)
   PUBMED   27693506
  REMARK    GeneRIF: The cooperation between TRIM16 and Galectin-3 in targeting
            and activation of selective autophagy protects cells from lysosomal
            damage and Mycobacterium tuberculosis invasion.
REFERENCE   5  (residues 1 to 564)
  AUTHORS   Kim PY, Tan O, Liu B, Trahair T, Liu T, Haber M, Norris MD,
            Marshall GM and Cheung BB.
  TITLE     High TDP43 expression is required for TRIM16-induced inhibition of
            cancer cell growth and correlated with good prognosis of
            neuroblastoma and breast cancer patients
  JOURNAL   Cancer Lett. 374 (2), 315-323 (2016)
   PUBMED   26902425
  REMARK    GeneRIF: Data suggest that TRIM16 and TDP43 are both good prognosis
            indicators; data shows that TRIM16 inhibits cancer cell viability
            by a novel mechanism involving interaction and stabilisation of
            TDP43 with consequent effects on E2F1 and pRb proteins.
REFERENCE   6  (residues 1 to 564)
  AUTHORS   Gwinn MR, Whipkey DL, Tennant LB and Weston A.
  TITLE     Differential gene expression in normal human mammary epithelial
            cells treated with malathion monitored by DNA microarrays
  JOURNAL   Environ. Health Perspect. 113 (8), 1046-1051 (2005)
   PUBMED   16079077
REFERENCE   7  (residues 1 to 564)
  AUTHORS   Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villen J, Li
            J, Cohn MA, Cantley LC and Gygi SP.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   8  (residues 1 to 564)
  AUTHORS   Beer HD, Munding C, Dubois N, Mamie C, Hohl D and Werner S.
  TITLE     The estrogen-responsive B box protein: a novel regulator of
            keratinocyte differentiation
  JOURNAL   J. Biol. Chem. 277 (23), 20740-20749 (2002)
   PUBMED   11919186
  REMARK    GeneRIF: role in regulating keratinocyte differentiation
REFERENCE   9  (residues 1 to 564)
  AUTHORS   Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L,
            Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci
            S, Pelicci PG and Ballabio A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J. 20 (9), 2140-2151 (2001)
   PUBMED   11331580
REFERENCE   10 (residues 1 to 564)
  AUTHORS   Liu HL, Golder-Novoselsky E, Seto MH, Webster L, McClary J and
            Zajchowski DA.
  TITLE     The novel estrogen-responsive B-box protein (EBBP) gene is
            tamoxifen-regulated in cells expressing an estrogen receptor
            DNA-binding domain mutant
  JOURNAL   Mol. Endocrinol. 12 (11), 1733-1748 (1998)
   PUBMED   9817599
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005324.1.
            
            Summary: The protein encoded by this gene is a tripartite motif
            (TRIM) family member that contains two B box domains and a
            coiled-coiled region that are characteristic of the B box zinc
            finger protein family. While it lacks a RING domain found in other
            TRIM proteins, the encoded protein can homodimerize or
            heterodimerize with other TRIM proteins and has E3 ubiquitin ligase
            activity. This gene is also a tumor suppressor and is involved in
            secretory autophagy. [provided by RefSeq, Jan 2017].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a). Variants 1, 2, and
            3 all encode the same isoform (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.247571.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..564
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p12"
     Protein         1..564
                     /product="tripartite motif-containing protein 16 isoform
                     a"
                     /note="estrogen-responsive B box protein; tripartite
                     motif-containing protein 16"
                     /calculated_mol_wt=63824
     Region          <164 ..="">283
                     /region_name="HlyD"
                     /note="HlyD membrane-fusion protein of T1SS; cl25633"
                     /db_xref="CDD:330454"
     Region          365..546
                     /region_name="SPRY_PRY_TRIM16"
                     /note="PRY/SPRY domain in tripartite motif-containing
                     protein 16 (TRIM16); cd12890"
                     /db_xref="CDD:293948"
     CDS             1..564
                     /gene="TRIM16"
                     /gene_synonym="EBBP"
                     /coded_by="NM_001348119.1:1015..2709"
                     /note="isoform a is encoded by transcript variant 1"
                     /db_xref="GeneID:10626"
                     /db_xref="HGNC:HGNC:17241"
                     /db_xref="MIM:609505"
ORIGIN      
        1 maeldlmapg plprataqpp aplspdsgsp spdsgsaspv eeedvgssek lgreteeqds
       61 dsaeqgdpag egkevlcdfc lddtrrvkav kscltcmvny ceehlqphqv niklqshllt
      121 epvkdhnwry cpahhsplsa fccpdqqcic qdccqehsgh tivsldaarr dkeaelqctq
      181 ldlerklkln enaisrlqan qksvlvsvse vkavaemqfg ellaavrkaq anvmlfleek
      241 eqaalsqang ikahleyrsa emekskqele rmaaisntvq fleeyckfkn teditfpsvy
      301 vglkdklsgi rkvitestvh liqllenykk klqefskeee ydirtqvsav vqrkywtskp
      361 epstreqflq yayditfdpd tahkylrlqe enrkvtnttp wehpypdlps rflhwrqvls
      421 qqslylhryy feveifgagt yvgltckgid rkgeernsci sgnnfswslq wngkeftawy
      481 sdmetplkag pfrrlgvyid fpggilsfyg veydtmtlvh kfackfsepv yaafwlskke
      541 nairivdlge epekpapslv gtap