ZFYVE15 (19q12), PLEKHF1, APID, LAPF, PHAFIN1

https://www.ncbi.nlm.nih.gov/gene/79156

Alsoo known as

APPD; LAPF; PHAFIN1; ZFYVE15

Expression

Ubiquitous expression in fat (RPKM 4.0), spleen (RPKM 2.2) and 24 other tissues See more

Preferred Names

pleckstrin homology domain-containing family F member 1

Names

PH and FYVE domain-containing protein 1

PH domain-containing family F member 1

apoptosis-inducing protein D,  (AIPD)

lysosome-associated apoptosis-inducing protein containing PH and FYVE domains (LAPF)

phafin 1, (PHAFIN1)

pleckstrin homology domain containing, family F (with FYVE domain) member 1, (PLEKHF1)

zinc finger FYVE domain-containing protein 15 ,(ZFYVE15)

Related articles in PubMed

1. The lysosome-associated apoptosis-inducing protein containing the pleckstrin homology (PH) and FYVE domains (LAPF), representative of a novel family of PH and FYVE domain-containing proteins, induces caspase-independent apoptosis via the lysosomal-mitochondrial pathway. Chen W, et al. J Biol Chem, 2005 Dec 9. PMID 16188880
2. Lysosomal targeting of phafin1 mediated by Rab7 induces autophagosome formation. Lin WJ, et al. Biochem Biophys Res Commun, 2012 Jan 6. PMID 22115783
3. Towards a proteome-scale map of the human protein-protein interaction network. Rual JF, et al. Nature, 2005 Oct 20. PMID 16189514
4. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. Maruyama K, et al. Gene, 1994 Jan 28. PMID 8125298
5. Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348

See all (10) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

What's a GeneRIF?

1. The results suggest that in addition to its role in endosome transport, phafin1 is also involved in lysosomal targeting and autophagosome formation.
2. functional characterization of LAPF, a novel lysosome-associated apoptosis-inducing protein containing PH and FYVE domains; LAPF may launch caspase-independent apoptosis through the lysosomal-mitochondrial pathway 

Structure:
 

1. NM_024310.5 → NP_077286.3  pleckstrin homology domain-containing family F member 1
   See identical proteins and their annotated locations for NP_077286.3
   
   Status: VALIDATED

   Source sequence(s)

   AY037145, BC018876

   Consensus CDS

   CCDS12417.1

   UniProtKB/Swiss-Prot

   Q96S99

   Related

   ENSP00000389787.2, ENST00000436066.4

   Conserved Domains (2) summary

   cd01218
   Location:7 → 129

   PH_Phafin2-like; Phafin2 (also called EAPF, FLJ13187, ZFYVE18 or PLEKHF2) Pleckstrin Homology (PH) domain

   cd15754
   Location:148 → 211

   FYVE_PKHF1; FYVE domain found in protein containing both PH and FYVE domains 1 (phafin-1) and similar proteins