KCTD13 (16p11.2)

https://www.ncbi.nlm.nih.gov/gene/253980

Official Symbol

KCTD13

Official Full Name

potassium channel tetramerization domain containing 13provided by HGNC

Also known as

PDIP1; FKSG86; BACURD1; POLDIP1; hBACURD1

Expression

Broad expression in testis (RPKM 12.8), brain (RPKM 4.9) and 23 other tissues See more

Preferred Names

BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

Names

BTB/POZ domain-containing protein KCTD13

CTD-2574D22.4

TNFAIP1-like protein

polymerase delta-interacting protein 1; (PDIP1)

potassium channel tetramerisation domain containing 13; (KCTD13 )

https://www.ncbi.nlm.nih.gov/protein/NP_849194.1

BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 [Homo sapiens]

NCBI Reference Sequence: NP_849194.1

Identical Proteins FASTA Graphics

 

Related articles in PubMed

1. Identification of rare variants in KCTD13 at the schizophrenia risk locus 16p11.2. Degenhardt F, et al. Psychiatr Genet, 2016 Dec. PMID 27668412, Free PMC Article
2. The effect of copy number variations in chromosome 16p on body weight in patients with intellectual disability. Gimeno-Ferrer F, et al. J Hum Genet, 2019 Mar. PMID 30518945
3. KCTD13 is a major driver of mirrored neuroanatomical phenotypes of the 16p11.2 copy number variant. Golzio C, et al. Nature, 2012 May 16. PMID 22596160, Free PMC Article
4. A tumor necrosis factor alpha- and interleukin 6-inducible protein that interacts with the small subunit of DNA polymerase delta and proliferating cell nuclear antigen. He H, et al. Proc Natl Acad Sci U S A, 2001 Oct 9. PMID 11593007, Free PMC Article
5. Cloning of two rat PDIP1 related genes and their interactions with proliferating cell nuclear antigen. Zhou J, et al. J Exp Zool A Comp Exp Biol, 2005 Mar 1. PMID 15726626

See all (37) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

1. Copy number variations in KCTD13 gene is associated with proximal syndromes with intellectual disability.
2. Present study explores the role of KCTD13 in the development of SCZ and to provide a more complete picture of the allelic architecture at this risk locus.
3. data suggest that KCTD13 is a major driver for the neurodevelopmental phenotypes associated with the 16p11.2 copy number variants (CNV), and reinforce the idea that one or a small number of transcripts within a CNV can underpin clinical phenotypes
4. PDIP1 mRNA was expressed in 3T3-L1 adipocytes and THP-1 macrophages
5.  Analysis of HIV-1 proviral integration sites in antiretroviral treatment patients indicates that KCTD13 gene favors HIV-1 integration for expansion and persistence of infected cells, suggesting HIV-1 IN interacts with KCTD13