ZFYVE geenejä ainakin 31. ( Ei transkriptiotekijöitä)

 ZFYVE1, SR3, Pho9sphoinositide bining  protein SR3, Tandem FYVE fingers 1, TAFF1,
Double  Fyve domain containing protein 1 DFCP1 
https://www.creativebiomart.net/symbolsearch_zfyve1.htm
https://www.sciencedirect.com/science/article/pii/S016748891100317X?via%3Dihub
( Kolokalisoituminen  TRIM13 /LEU5(CAR) kanssa  ER stressissä  (P62/SQSTM1),;   autofagian aloitus ja klonogeenisyyden aleneminen.  Merkitystä kroonisessa lymfaattisessa leukemiassa CLL ja multippelissa myelomassa MM).

ZFYVE2(12q22), EEA1, early endosome antigen 1.MST105, MSTP105
(Exp. oesophagus, fat)

https://www.ncbi.nlm.nih.gov/gene/841
(Erikoinen rakenne: paljon q ja e)

Preferred Names

early endosome antigen 1

Names

early endosome antigen 1, 162kD

early endosome-associated protein

endosome-associated protein p162

zinc finger FYVE domain-containing protein 

https://www.ncbi.nlm.nih.gov/pubmed/24491918/

ZFYVE3 (Xp11.22) . FGD1, AAS, FGDY, MRXS1b (Exp. endometrium, brain)

ZFYVE4 (6p21.2) FYVE, FGD2 (Expr. spleen, lymphanode) 

ZFYVE5 (9q22.31), FGD3 (Expr. spleen, lymph node)

https://www.ncbi.nlm.nih.gov/gene/89846 
Undergoes SCF/FWD1/beta-TrCP- mediated proteosomal degradation. 


ZFYVE6 (12p11.21), FGD4, CMT4H, FRABP .Regul. actin cytoskeleton of cell shape. ( Ca prostatae  cell migration promoting, Cruyptosporidium invasion   ic)
https://www.ncbi.nlm.nih.gov/gene/121512

ZFYVE7(3p21.31), FYCO1, CATC2, CTRCT18, RUFY3 ( expr. HEART, ENDOMETRIUM)
https://www.ncbi.nlm.nih.gov/gene/79443 This gene encodes a protein that contains a RUN domain, FYVE-type zinc finger domain and Golgi dynamics (GOLD) domain. The encoded protein plays a role in microtubule plus end-directed transport of autophagic vesicles through interactions with the small GTPase Rab7, phosphatidylinositol-3-phosphate (PI3P) and the autophagosome marker LC3. Mutations in this gene are a cause of autosomal recessive congenital cataract-2 (CATC2). [provided by RefSeq, Dec 2011]

ZFYVE8.(17q25.3)    HGS, Hepatocyte Growth factor regulated tyr kinase Substrate.,
 https://www.ncbi.nlm.nih.gov/gene/9146
Preferred Names  hepatocyte growth factor-regulated tyrosine kinase substrate (HGS)

Names  human growth factor-regulated tyrosine kinase substrate (HRS)

protein pp110

ZFYVE19 (15q15.1) ,ANCHR,(Abscission/NoCut  Checkpoint Regulator), MPFYVE
 https://www.ncbi.nlm.nih.gov/gene/?term=ZFYVE19

Also known as

ANCHR; MPFYVE

Expression

Ubiquitous expression in duodenum (RPKM 6.2), small intestine (RPKM 6.1) and 25 other tissues See more

Orthologs

mouse all

Abstracthttps://www.ncbi.nlm.nih.gov/pubmed/24814515/

During the final stage of cell division, cytokinesis, the Aurora-B-dependent abscission checkpoint (NoCut) delays membrane abscission to avoid DNA damage and aneuploidy in cells with chromosome segregation defects. This arrest depends on Aurora-B-mediated phosphorylation of CHMP4C, a component of the endosomal sorting complex required for transport (ESCRT) machinery that mediates abscission, but the mechanism remains unknown. Here we describe ANCHR (Abscission/NoCut Checkpoint Regulator; ZFYVE19) as a key regulator of the abscission checkpoint, functioning through the most downstream component of the ESCRT machinery, the ATPase VPS4. In concert with CHMP4C, ANCHR associates with VPS4 at the midbody ring following DNA segregation defects to control abscission timing and prevent multinucleation in an Aurora-B-dependent manner. This association prevents VPS4 relocalization to the abscission zone and is relieved following inactivation of Aurora B to allow abscission. We propose that the abscission checkpoint is mediated by ANCHR and CHMP4C through retention of VPS4 at the midbody ring.

ZFYVE26, FYVE-CENT (14q24.1) Spastizin, SPG15, Spatic Paraplegia 15.
https://genecards.weizmann.ac.il/v3/cgi-bin/carddisp.pl?gene=ZFYVE26

ZFYVE28  (LST, LYST ( 4p16.3) Testis,brain)Prionproteiinin eräs interaktioproteiini. PrPIP
 https://www.ncbi.nlm.nih.gov/gene/57732
https://onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2990.2008.00947.x

ZFYVE29, PIKFYVE (2q34).Yllättävää! Tämä on fosfatiyyli-inositidi-kinaasi PIP5K, PIP5K3.  Asetan  Phytin- blogiini. Geeni ekspressoituu luuytimessä ja imusolmukkeessa. APP intrasellulaarinen  osa tekee nteraktion PIKFYVE kompleksin kanssa ja merkitsee endosomaalisessa homeostaasissa ja lajittelussa. Nin APP:lle on löytynyt fysiologinen tehtävä.
https://www.ncbi.nlm.nih.gov/gene/200576

Preferred Names

1-phosphatidylinositol 3-phosphate 5-kinase

Names

PIPkin-III

epididymis luminal protein 37

phosphatidylinositol 3-phosphate 5-kinase type III

phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III

phosphoinositide kinase, FYVE finger containing

type III PIP kinase

zinc finger, FYVE domain containing 29

ZFYVE30 , RUFY3( 14q33) RIPX, SINGAR1, .Neuronaalinen polariteetti.
https://www.ncbi.nlm.nih.gov/gene/?term=ZFYVE30

Preferred Names

protein RUFY3

Names

rap2 interacting protein x

single axon-regulated protein

single axon-related 1

ZFYVE31, RUFY4 (2q35), Spleen, lymph node
https://www.ncbi.nlm.nih.gov/gene/?term=ZFYVE31


ZFYVE32